The preclinical development of regorafenib for the treatment of colorectal cancer

Expert Opinion on Drug Discovery

Volumn 9, Issue 9, 2014, Pages 1087-1101

  Miura, Koh ^a   Satoh, Masayuki ^a   Kinouchi, Makoto ^a   Yamamoto, Kuniharu ^a   Hasegawa, Yasuhiro ^a   Philchenkov, Alex ^b   Kakugawa, Yoichiro ^a   Fujiya, Tsuneaki ^a  

^a Miyagi Cancer Center   (Japan)

^b R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

Author keywords

Colorectal cancer; Kinase inhibitor; Preclinical development; Regorafenib; Small molecule agents; Sorafenib; Targeted agents

Indexed keywords

REGORAFENIB; SORAFENIB; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; CLINICAL TRIAL (TOPIC); COLORECTAL CANCER; DRUG DESIGN; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; HUMAN; PRIORITY JOURNAL; REVIEW; UNSPECIFIED SIDE EFFECT; ANALOGS AND DERIVATIVES; ANIMAL; COLORECTAL NEOPLASMS; DRUG DEVELOPMENT; PATHOLOGY;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; COLORECTAL NEOPLASMS; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; NIACINAMIDE; PHENYLUREA COMPOUNDS; PROTEIN KINASE INHIBITORS; PYRIDINES;

EID: 84906349046     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2014.924923     Document Type: Review

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