Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling

Journal of Vascular Surgery

Volumn 62, Issue 1, 2015, Pages 210-221.e2

  Hsu, Yu Juei ^a   Hsu, Shih Che ^b   Huang, Shih Ming ^b   Lee, Herng Sheng ^a   Lin, Shih Hua ^a   Tsai, Chien Sung ^a   Shih, Chun Che ^c   Lin, Chih Yuan ^a,c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; CASPASE 3; CREATININE; FOSCARNET; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATE; PROTEIN KINASE B; RAPAMYCIN; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; LC3 PROTEIN, RAT; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, HUMAN; MTOR PROTEIN, RAT; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CAPILLARY ENDOTHELIAL CELL; CARDIOVASCULAR FUNCTION; CELL PROTECTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERPHOSPHATEMIA; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NEPHRECTOMY; NONHUMAN; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; YOUNG ADULT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHRONIC KIDNEY FAILURE; COMPLICATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; TIME; WISTAR RAT;

ADENINE; ANIMALS; AUTOPHAGY; CELL LINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FOSCARNET; HUMANS; HYPERPHOSPHATEMIA; MALE; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHATES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS; TOR SERINE-THREONINE KINASES; TRANSFECTION;

EID: 84932634220     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2014.02.040     Document Type: Article

References (40)

1. L. Craver, M.P. Marco, I. Martinez, M. Rue, M. Borras, M.L. Martin, and et al. Mineral metabolism parameters throughout chronic kidney disease stages 1-5 - achievement of K/DOQI target ranges Nephrol Dial Transplant 22 2007 1171 1176
2. A.S. Go, G.M. Chertow, D. Fan, C.E. McCulloch, and C.Y. Hsu Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization N Engl J Med 351 2004 1296 1305
3. 4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients J Am Soc Nephrol 12 2001 2131 2138
4. G.A. Block, P.S. Klassen, J.M. Lazarus, N. Ofsthun, E.G. Lowrie, and G.M. Chertow Mineral metabolism, mortality, and morbidity in maintenance hemodialysis J Am Soc Nephrol 15 2004 2208 2218
5. C.M. Shanahan, N.R. Cary, J.R. Salisbury, D. Proudfoot, P.L. Weissberg, and M.E. Edmonds Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification Circulation 100 1999 2168 2176
6. S.M. Moe, and N.X. Chen Pathophysiology of vascular calcification in chronic kidney disease Circ Res 95 2004 560 567
7. K.L. Tyson, J.L. Reynolds, R. McNair, Q. Zhang, P.L. Weissberg, and C.M. Shanahan Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification Arterioscler Thromb Vas Biol 23 2003 489 494
8. R. Dhingra, L.M. Sullivan, C.S. Fox, T.J. Wang, R.B. D'Aqostino Sr., J.M. Gaziano, and et al. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community Arch Intern Med 167 2007 879 885
9. G.S. Di Marco, M. Hausberg, U. Hillebrand, P. Rustemeyer, W. Wittkowski, D. Lang, and et al. Increased inorganic phosphate induces human endothelial cell apoptosis in vitro Am J Physiol Renal Physiol 294 2008 F1381 F1387
10. A. Peng, T. Wu, C. Zeng, D. Rakheja, J. Zhu, T. Ye, and et al. Adverse effects of simulated hyper- and hypo-phosphatemia on endothelial cell function and viability PLoS One 6 2011 e23268
11. E. Shuto, Y. Taketani, R. Tanaka, N. Harada, M. Isshiki, M. Sato, and et al. Dietary phosphorus acutely impairs endothelial function J Am Soc Nephrol 20 2009 1504 1512
12. D.J. Klionsky, and S.D. Emr Autophagy as a regulated pathway of cellular degradation Science 290 2000 1717 1721
13. A.M. Choi, S.W. Ryter, and B. Levine Autophagy in human health and disease N Engl J Med 368 2013 1845 1846
14. W. Martinet, M.W. Knaapen, M.M. Kockx, and G.R. De Meyer Autophagy in cardiovascular disease Trends Mol Med 13 2007 482 491
15. A. Nemchenko, M. Chiong, A. Turer, S. Lavandero, and J.A. Hill Autophagy as a therapeutic target in cardiovascular disease J Mol Cell Cardiol 51 2011 584 593
16. S. Lavandero, R. Troncoso, B.A. Rothermel, W. Martinet, J. Sadoshima, and J.A. Hill Cardiovascular autophagy: concepts, controversies and perspectives Autophagy 9 2013 Aug 14 [Epub ahead of print]
17. D.M. Schrijvers, G.R. De Meyer, and W. Martinet Autophagy in atherosclerosis: a potential drug target for plaque stabilization Arterioscler Thromb Vasc Biol 31 2011 2787 2791
18. W. Martinet, and G.R. De Meyer Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential Circ Res 104 2009 304 317
19. Z. Yang, and D.J. Klionsky Mammalian autophagy: core molecular machinery and signaling regulation Curr Opin Cell Biol 22 2010 124 131
20. C. He, and D.J. Klionsky Regulation mechanisms and signaling pathways of autophagy Annu Rev Genet 43 2009 67 93
21. Z.Z. Chong, Y.C. Shang, and K. Maiese Cardiovascular disease and mTOR signaling Trends Cardiovasc Med 21 2011 151 155
22. C.Y. Lin, S.C. Hsu, H.S. Lee, S.H. Lin, C.S. Tsai, S.M. Huang, and et al. Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure J Vasc Surg 57 2013 475 485
23. M. Nowicki, O. Zabirnyk, N. Duerrschmidt, J. Borlak, and K. Spanel-Borowski No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy Eur J Cell Biol 86 2007 605 616
24. W. Shen, C. Tian, H. Chen, Y. Yang, D. Zhu, P. Gao, and et al. Oxidative stress mediates chemerin-induced autophagy in endothelial cells Free Radic Biol Med 55 2013 73 82
25. Q. Wang, B. Liang, N.A. Shirwany, and M.H. Zou 2-Deoxy-d-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase PLoS One 6 2011 e17234
26. Z. Dong, L. Wang, J. Xu, Y. Li, Y. Zhang, S. Zhang, and et al. Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells Toxicol In Vitro 23 2009 105 110
27. Y. Xie, S.J. You, Y.L. Zhang, Q. Han, Y.J. Cao, X.S. Xu, and et al. Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells Mol Med Rep 4 2011 459 464
28. J. Han, X.Y. Pan, Y. Xu, Y. Xiao, Y. An, L. Tie, and et al. Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage Autophagy 8 2012 812 825
29. M.J. Khan, M. Rizwan Alam, M. Waldeck-Weiermair, F. Karsten, L. Groschner, M. Riederer, and et al. Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells J Biol Chem 287 2012 21110 21120
30. N. Hernando, I.C. Forster, J. Biber, and H. Murer Molecular characteristics of phosphate transporters and their regulation Exp Nephrol 8 2000 366 375
31. L.V. Virkki, J. Biber, H. Murer, and I.C. Forster Phosphate transporters: a tale of two solute carrier families Am J Physiol Renal Physiol 293 2007 F643 F654
32. X. Li, and C.M. Giachelli Sodium-dependent phosphate cotransporters and vascular calcification Curr Opin Nephrol Hypertens 16 2007 325 328
33. X. Li, H.Y. Yang, and C.M. Giachelli Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification Circ Res 98 2006 905 912
34. G.S. Di Marco, M. Konig, C. Stock, A. Wiesinger, U. Hillebrand, S. Reiermann, and et al. High phosphate directly affects endothelial function by downregulating annexin II Kidney Int 83 2013 213 222
35. J. LoPiccolo, G.M. Blumenthal, W.B. Bernstein, and P.A. Dennis Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations Drug Resist Updat 11 2008 32 50
36. Y. Kamada, T. Funakoshi, T. Shintani, K. Nagano, M. Ohsumi, and Y. Ohsumi Tor-mediated induction of autophagy via an Apg1 protein kinase complex J Cell Biol 150 2000 1507 1513
37. T.P. Neufeld TOR-dependent control of autophagy: biting the hand that feeds Curr Opin Cell Biol 22 2010 157 168
38. W. Martinet, D.M. Schrijvers, J.P. Timmermans, and H. Bult Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells Br J Pharmacol 154 2008 1236 1246
39. A. Hamacher-Brady, N.R. Brady, and R.A. Gottlieb The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy Cardiovasc Drugs Ther 20 2006 445 462
40. A. Hamacher-Brady, N.R. Brady, S.E. Logue, M.R. Sayen, M. Jinno, L.A. Kirshenbaum, and et al. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy Cell Death Differ 14 2007 146 157