Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: Evidence for smooth muscle cell-mediated vascular calcification

Circulation

Volumn 100, Issue 21, 1999, Pages 2168-2176

  Shanahan, Catherine M ^a   Cary, Nathaniel R B ^b   Salisbury, Jon R ^c   Proudfoot, Diane ^a   Weissberg, Peter L ^a   Edmonds, Mike E ^c  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cartilage; Diabetes mellitus; Muscle; Osteopontin; Proteins; Smooth

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 2; MATRIX PROTEIN; OSTEOCALCIN; OSTEONECTIN; SIALOPROTEIN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL CALCIFICATION; BONE DEVELOPMENT; CARDIOVASCULAR RISK; CHONDROGENESIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCATION; HUMAN; HUMAN CELL; MALE; MINERALIZATION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SMOOTH MUSCLE FIBER;

EID: 0033598796     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.100.21.2168     Document Type: Article

References (38)

1. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcification using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-832.
2. Richardson PD, Davies MJ, Born GVR. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet. 1989;2:141-144.
3. Loecker TH, Schwartz RS, Cotta CW, Hickman JR. Fluoroscopic coronary artery calcification and associated coronary disease in asymptomatic young men. J Am Coll Cardiol. 1992;19:1167-1172.
4. Proudfoot D, Shanahan CM, Weissberg PL. Vascular calcification: new insights into an old problem. J Pathol. 1998;185:1-3.
5. Lento S, Niskanen L, Suhonen M, Ronnemaa T, Laakso M. Medial artery calcification: a neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol. 1996;16:978-983.
6. Stehbens WE. Atherosclerosis and degenerative diseases of blood vessels. In: Stehbens WE, Lie JT, eds. Vascular Pathology. London, UK: Chapman & Hall Medical; 1995.
7. Giachelli CM, Bae N, Almeida M, Denhardt DT, Alpers CE, Schwartz SM. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest. 1993;92:1686-1696.
8. Shanahan CM, Cary NRB, Metcalfe JC, Weissberg PL. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest. 1994;93:2393-2402.
9. Raines EW, Lane TF, Iruela-Arispe ML, Ross R, Sage EH. The extra-cellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci USA. 1992;89:1281-1285.
10. Bostrom K, Watson KE, Horn S, Wortham C, Herman IM, Demer LL. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993;91:1800-1809.
11. Shanahan CM, Cary NRB, Osbourn JK, Weissberg PL. Identification of osteoglycin as a component of the vascular matrix: differential expression by vascular smooth muscle cells during neointima formation and in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 1997;17: 2437-2447.
12. Isner J, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation. 1995;91:2703-2711.
13. Hirsch D, Azoury R, Sarig S, Druth HS. Colocalization of cholesterol and hydroxyapatite in human atherosclerotic lesions. Calcif Tissue Int. 1993; 52:94-98.
14. Tanimura A, McGregor DH, Anderson HC. Matrix vesicles in atherosclerotic calcification. Proc Soc Exp Biol Med. 1983;172:173-177.
15. Anderson HC. Biology of disease: mechanism of mineral formation in bone. Lab Invest. 1989;60:320-330.
16. Doherty TM, Detrano RC. Coronary arterial calcification as an active process: a new perspective on an old problem. Calcif Tissue Int. 1994; 54:224-230.
17. Demer LL. A skeleton in the atherosclerosis closet. Circulation. 1995; 92:2029-2032.
18. Mönckeberg JG. Uber die reine Mediaverkalkung der Extremitätenarterien und ihr Verhalten zur Arteriosklerose. Virchows Arch Pathol Anat. 1902;171:141-167.
19. Edmonds ME, Morrison N, Laws JW, Watkins PJ. Medial arterial calcification and diabetic neuropathy. Br Med J. 1982;284:928-930.
20. Everhart JE, Pettitt DJ, Knowler WC, Rose FA, Bennett PH. Medial arterial calcification and its association with mortality and complications of diabetes. Diabetologia. 1988;31:16-23.
21. Niskanen L, Siitonen O, Suhonen M, Uusitupa MI. Medial artery calcification predicts cardiovascular mortality in patients with NIDDM. Diabetes Care. 1994;17:1252-1256.
22. Forst T, Pfutzner A, Kann P, Lobmann R, Schafer H, Beyer J. Association between diabetic-autonomic-C-fibre-neuropathy and medial wall calcification and the significance in the outcome of trophic foot lesions. Exp Clin Endocrinol Diabetes. 1995;103:94-98.
23. Chantelau E, Lee KM, Jungblut R. Association of below-knee atherosclerosis to medial arterial calcification in diabetes-mellitus. Diabetes Res Clin Pract. 1995;29:169-172.
24. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997;386:78-81.
25. Loeser R, Carlson CS, Tulli H, Jerome WG, Miller L, Wallin R. Articular-cartilage matrix γ-carboxyglutamic acid-containing protein: characterization and immunolocalization. Biochem J. 1992;282:1-6.
26. Proudfoot D, Skepper J, Shanahan CM, Weissberg PL. Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression. Arterioscler Thromb Vasc Biol. 1998;18:379-388.
27. Shanahan CM, Proudfoot D, Farzeneh-Far A, Weissberg PL. The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr. 1998;8:357-375.
28. Denhardt DT, Guo X. Osteopontin: a protein with diverse functions. FASEB J. 1993;7:1475-1482.
29. McKee MD, Nanci A. Osteopontin at mineralized tissue interfaces in bone, teeth and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover and repair. Microsc Res Tech. 1996;33:141-164.
30. Anderson HC. Molecular biology of matrix vesicles. Clin Ortho Rel Res. 1995;314:266-280.
31. Hunter GK, Goldberg HA. Nucleation of hydroxyapatite by bone sialo-protein. Proc Natl Acad Sci USA. 1993;90:8562-8565.
32. Stubbs JT, Mintz KP, Eanes ED, Torchia DA, Fisher LW. Characterization of native and recombinant bone sialoprotein: delineation of the mineral-binding and cell adhesion domains and structural analysis of the ROD domain. J Bone Miner Res. 1997;12:1210-1222.
33. Romberg RW, Werness PG, Riggs BL, Mann KG. Inhibition of hydroxyapatite crystal growth by bone-specific and other calcium-binding proteins. Biochemistry. 1986;25:1176-1180.
34. Ducy P, Desbois CD, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G. Increased bone formation in osteocalcin-deficient mice. Nature. 1996;382: 448-452.
35. Srivatsa SS, Harrity PJ, Maercklein PB, Kleppe L, Veinot J, Edwards WD, Johnson CM, Fitzpatrick LA. Increased cellular expression of matrix proteins that regulate mineralization is associated with calcification of native human and porcine xenograft bioprosthetic heart valves. J Clin Invest. 1997;99:996-1009.
36. Termine JD, Kleinman HD, Whitson SW, Conn KM, McGarvey ML, Martin GR. Osteonectin, a bone-specific protein linking mineral to collagen. Cell. 1981;26:99-105.
37. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Krtiz RW, Hewick RM, Wang EA. Novel regulators of bone formation: molecular clones and activities. Science. 1988;242:1528-1534.
38. Doherty MJ, Ashton BA, Walsh S, Beresford JN, Grant ME, Canfield AE. Vascular pericytes express osteogenic potential in vitro and in vivo. J Bone Miner Res. 1998;13:828-838.