-
1
-
-
79959463520
-
Regulation of HSF1 function in the heat stress response: implications in aging and disease
-
Anckar J, Sistonen L. 2011. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem 80:1089-1115. http://dx.doi.org/10.1146/annurev-biochem-060809-095203.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 1089-1115
-
-
Anckar, J.1
Sistonen, L.2
-
2
-
-
78649346692
-
The heat shock response: life on the verge of death
-
Richter K, Haslbeck M, Buchner J. 2010. The heat shock response: life on the verge of death. Mol Cell 40:253-266. http://dx.doi.org/10.1016/j.molcel.2010.10.006.
-
(2010)
Mol Cell
, vol.40
, pp. 253-266
-
-
Richter, K.1
Haslbeck, M.2
Buchner, J.3
-
3
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl FU, Bracher A, Hayer-Hartl M. 2011. Molecular chaperones in protein folding and proteostasis. Nature 475:324-332. http://dx.doi.org/10.1038/nature10317.
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
4
-
-
77954955686
-
Heat shock factors: integrators of cell stress, development, and life span
-
Åkerfelt M, Morimoto RI, Sistonen L. 2010. Heat shock factors: integrators of cell stress, development, and life span. Nat Rev Mol Cell Biol 11: 545-555. http://dx.doi.org/10.1038/nrm2938.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 545-555
-
-
Åkerfelt, M.1
Morimoto, R.I.2
Sistonen, L.3
-
5
-
-
0023694311
-
Key features of heat shock regulatory elements
-
Amin J, Ananthan J, Voellmy R. 1988. Key features of heat shock regulatory elements. Mol Cell Biol 8:3761-3769.
-
(1988)
Mol Cell Biol
, vol.8
, pp. 3761-3769
-
-
Amin, J.1
Ananthan, J.2
Voellmy, R.3
-
6
-
-
0032936785
-
A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal
-
Littlefield O, Nelson HCM. 1999. A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal. Nat Struct Mol Biol 6:464-470. http://dx.doi.org/10.1038/8269.
-
(1999)
Nat Struct Mol Biol
, vol.6
, pp. 464-470
-
-
Littlefield, O.1
Nelson, H.C.M.2
-
7
-
-
1542373742
-
The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response
-
Trinklein ND, Murray JI, Hartman SJ, Botstein D, Myers RM. 2004. The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response. Mol Biol Cell 15:1254-1261. http://dx.doi.org/10.1091/mbc.E03-10-0738.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1254-1261
-
-
Trinklein, N.D.1
Murray, J.I.2
Hartman, S.J.3
Botstein, D.4
Myers, R.M.5
-
8
-
-
84883321205
-
Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells
-
Vihervaara A, Sergelius C, Vasara J, Blom MAH, Elsing AN, Roos-Mattjus P, Sistonen L. 2013. Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells. Proc Natl Acad Sci U S A 110:E3388-E3397. http://dx.doi.org/10.1073/pnas.1305275110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E3388-E3397
-
-
Vihervaara, A.1
Sergelius, C.2
Vasara, J.3
Blom, M.A.H.4
Elsing, A.N.5
Roos-Mattjus, P.6
Sistonen, L.7
-
9
-
-
0032571397
-
Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis
-
McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ. 1998. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 273:7523-7528. http://dx.doi.org/10.1074/jbc.273.13.7523.
-
(1998)
J Biol Chem
, vol.273
, pp. 7523-7528
-
-
McMillan, D.R.1
Xiao, X.2
Shao, L.3
Graves, K.4
Benjamin, I.J.5
-
10
-
-
0033229880
-
HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
-
Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA, Benjamin IJ. 1999. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18:5943-5952. http://dx.doi.org/10.1093/emboj/18.21.5943.
-
(1999)
EMBO J
, vol.18
, pp. 5943-5952
-
-
Xiao, X.1
Zuo, X.2
Davis, A.A.3
McMillan, D.R.4
Curry, B.B.5
Richardson, J.A.6
Benjamin, I.J.7
-
11
-
-
0034641933
-
Embryonic development: maternal effect of Hsf1 on reproductive success
-
Christians E, Davis A, Thomas S, Benjamin I. 2000. Embryonic development: maternal effect of Hsf1 on reproductive success. Nature 407:693-694. http://dx.doi.org/10.1038/35037669.
-
(2000)
Nature
, vol.407
, pp. 693-694
-
-
Christians, E.1
Davis, A.2
Thomas, S.3
Benjamin, I.4
-
12
-
-
33751092252
-
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival
-
Page TJ, Sikder D, Yang L, Pluta L, Wolfinger RD, Kodadek T, Thomas RS. 2006. Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. Mol Biosystems 2:627-639. http://dx.doi.org/10.1039/b606129j.
-
(2006)
Mol Biosystems
, vol.2
, pp. 627-639
-
-
Page, T.J.1
Sikder, D.2
Yang, L.3
Pluta, L.4
Wolfinger, R.D.5
Kodadek, T.6
Thomas, R.S.7
-
13
-
-
0038701745
-
Regulation of aging and agerelated disease by DAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, Kenyon C. 2003. Regulation of aging and agerelated disease by DAF-16 and heat-shock factor. Science 300:1142-1145. http://dx.doi.org/10.1126/science.1083701.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
14
-
-
0742323000
-
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
-
Morley JF, Morimoto RI. 2004. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 15:657-664. http://dx.doi.org/10.1091/mbc.E03-07-0532.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 657-664
-
-
Morley, J.F.1
Morimoto, R.I.2
-
15
-
-
51649130437
-
Heat shock factor 1 regulates life span as distinct from disease onset in prion disease
-
Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S. 2008. Heat shock factor 1 regulates life span as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A 105:13626-13631. http://dx.doi.org/10.1073/pnas.0806319105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13626-13631
-
-
Steele, A.D.1
Hutter, G.2
Jackson, W.S.3
Heppner, F.L.4
Borkowski, A.W.5
King, O.D.6
Raymond, G.J.7
Aguzzi, A.8
Lindquist, S.9
-
16
-
-
4644335419
-
Impaired IgG production in mice deficient for heat shock transcription factor 1
-
Inouye S, Izu H, Takaki E, Suzuki H, Shirai M, Yokota Y, Ichikawa H, Fujimoto M, Nakai A. 2004. Impaired IgG production in mice deficient for heat shock transcription factor 1. J Biol Chem 279:38701-38709. http://dx.doi.org/10.1074/jbc.M405986200.
-
(2004)
J Biol Chem
, vol.279
, pp. 38701-38709
-
-
Inouye, S.1
Izu, H.2
Takaki, E.3
Suzuki, H.4
Shirai, M.5
Yokota, Y.6
Ichikawa, H.7
Fujimoto, M.8
Nakai, A.9
-
17
-
-
38949209515
-
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor
-
Reinke H, Saini C, Fleury-Olela F, Dibner C, Benjamin IJ, Schibler U. 2008. Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev 22:331-345. http://dx.doi.org/10.1101/gad.453808.
-
(2008)
Genes Dev
, vol.22
, pp. 331-345
-
-
Reinke, H.1
Saini, C.2
Fleury-Olela, F.3
Dibner, C.4
Benjamin, I.J.5
Schibler, U.6
-
18
-
-
34548658230
-
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
-
Dai C, Whitesell L, Rogers AB, Lindquist S. 2007. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130:1005-1018. http://dx.doi.org/10.1016/j.cell.2007.07.020.
-
(2007)
Cell
, vol.130
, pp. 1005-1018
-
-
Dai, C.1
Whitesell, L.2
Rogers, A.B.3
Lindquist, S.4
-
19
-
-
81055141345
-
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
-
Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. 2011. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A 108:18378-18383. http://dx.doi.org/10.1073/pnas.1115031108.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 18378-18383
-
-
Santagata, S.1
Hu, R.2
Lin, N.U.3
Mendillo, M.L.4
Collins, L.C.5
Hankinson, S.E.6
Schnitt, S.J.7
Whitesell, L.8
Tamimi, R.M.9
Lindquist, S.10
Ince, T.A.11
-
20
-
-
84864585171
-
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
-
Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. 2012. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 150:549-562. http://dx.doi.org/10.1016/j.cell.2012.06.031.
-
(2012)
Cell
, vol.150
, pp. 549-562
-
-
Mendillo, M.L.1
Santagata, S.2
Koeva, M.3
Bell, G.W.4
Hu, R.5
Tamimi, R.M.6
Fraenkel, E.7
Ince, T.A.8
Whitesell, L.9
Lindquist, S.10
-
21
-
-
0028500990
-
Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor
-
Vuister GW, Kim S, Orosz A, Marquardt J, Wu C, Bax A. 1994. Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor. Nat Struct Biol 1:605-614. http://dx.doi.org/10.1038/nsb0994-605.
-
(1994)
Nat Struct Biol
, vol.1
, pp. 605-614
-
-
Vuister, G.W.1
Kim, S.2
Orosz, A.3
Marquardt, J.4
Wu, C.5
Bax, A.6
-
22
-
-
0030049318
-
The regulatory domain of human heat shock factor 1 is sufficient to sense heat stress
-
Newton EM, Knauf U, Green M, Kingston RE. 1996. The regulatory domain of human heat shock factor 1 is sufficient to sense heat stress. Mol Cell Biol 16:839-846.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 839-846
-
-
Newton, E.M.1
Knauf, U.2
Green, M.3
Kingston, R.E.4
-
23
-
-
0024852809
-
Trimerization of a yeast transcriptional activator via a coiled-coil motif
-
Sorger PK, Nelson HCM. 1989. Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell 59:807-813. http://dx.doi.org/10.1016/0092-8674(89)90604-1.
-
(1989)
Cell
, vol.59
, pp. 807-813
-
-
Sorger, P.K.1
Nelson, H.C.M.2
-
24
-
-
0026621935
-
Trimerization of the heat shock transcription factor by a triple-stranded α-helical coiled coil
-
Peteranderl R, Nelson HCM. 1992. Trimerization of the heat shock transcription factor by a triple-stranded α-helical coiled coil. Biochemistry 31:12272-12276. http://dx.doi.org/10.1021/bi00163a042.
-
(1992)
Biochemistry
, vol.31
, pp. 12272-12276
-
-
Peteranderl, R.1
Nelson, H.C.M.2
-
25
-
-
0027452754
-
Regulation of heat shock factor trimer formation: role of a conserved leucine zipper
-
Rabindran SK, Haroun RI, Clos J, Wisniewski J, Wu C. 1993. Regulation of heat shock factor trimer formation: role of a conserved leucine zipper. Science 259:230-234. http://dx.doi.org/10.1126/science.8421783.
-
(1993)
Science
, vol.259
, pp. 230-234
-
-
Rabindran, S.K.1
Haroun, R.I.2
Clos, J.3
Wisniewski, J.4
Wu, C.5
-
26
-
-
0029055176
-
Multiple layers of regulation of human heat shock transcription factor 1
-
Zuo J, Rungger D, Voellmy R. 1995. Multiple layers of regulation of human heat shock transcription factor 1. Mol Cell Biol 15:4319-4330.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4319-4330
-
-
Zuo, J.1
Rungger, D.2
Voellmy, R.3
-
27
-
-
0029039963
-
A heat shockresponsive domain of human HSF1 that regulates transcription activation domain function
-
Green M, Schuetz TJ, Sullivan EK, Kingston RE. 1995. A heat shockresponsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol 15:3354-3362.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3354-3362
-
-
Green, M.1
Schuetz, T.J.2
Sullivan, E.K.3
Kingston, R.E.4
-
28
-
-
70450209178
-
Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity
-
Takemori Y, Enoki Y, Yamamoto N, Fukai Y, Adachi K, Sakurai H. 2009. Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity. Biochem J 424:253-261. http://dx.doi.org/10.1042/BJ20090922.
-
(2009)
Biochem J
, vol.424
, pp. 253-261
-
-
Takemori, Y.1
Enoki, Y.2
Yamamoto, N.3
Fukai, Y.4
Adachi, K.5
Sakurai, H.6
-
29
-
-
0037385213
-
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1
-
Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L. 2003. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol 23:2953-2968. http://dx.doi.org/10.1128/MCB.23.8.2953-2968.2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2953-2968
-
-
Hietakangas, V.1
Ahlskog, J.K.2
Jakobsson, A.M.3
Hellesuo, M.4
Sahlberg, N.M.5
Holmberg, C.I.6
Mikhailov, A.7
Palvimo, J.J.8
Pirkkala, L.9
Sistonen, L.10
-
30
-
-
18244384703
-
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress
-
Guettouche T, Boellmann F, Lane WS, Voellmy R. 2005. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem 6:4. http://dx.doi.org/10.1186/1471-2091-6-4.
-
(2005)
BMC Biochem
, vol.6
, pp. 4
-
-
Guettouche, T.1
Boellmann, F.2
Lane, W.S.3
Voellmy, R.4
-
31
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide SD, Anckar J, Stevens SM, Jr, Sistonen L, Morimoto RI. 2009. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323:1063-1066. http://dx.doi.org/10.1126/science.1165946.
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens, S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
32
-
-
84896843332
-
Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1
-
Raychaudhuri S, Loew C, Körner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU. 2014. Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1. Cell 156:975-985. http://dx.doi.org/10.1016/j.cell.2014.01.055.
-
(2014)
Cell
, vol.156
, pp. 975-985
-
-
Raychaudhuri, S.1
Loew, C.2
Körner, R.3
Pinkert, S.4
Theis, M.5
Hayer-Hartl, M.6
Buchholz, F.7
Hartl, F.U.8
-
33
-
-
84860623294
-
Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach
-
Xu YM, Huang DY, Chiu JF, Lau AT. 2012. Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach. J Proteome Res 11:2625-2634. http://dx.doi.org/10.1021/pr201151a.
-
(2012)
J Proteome Res
, vol.11
, pp. 2625-2634
-
-
Xu, Y.M.1
Huang, D.Y.2
Chiu, J.F.3
Lau, A.T.4
-
34
-
-
0029804194
-
Repression of human heat shock factor 1 activity at control temperature by phosphorylation
-
Knauf U, Newton EM, Kyriakis J, Kingston RE. 1996. Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev 10:2782-2793. http://dx.doi.org/10.1101/gad.10.21.2782.
-
(1996)
Genes Dev
, vol.10
, pp. 2782-2793
-
-
Knauf, U.1
Newton, E.M.2
Kyriakis, J.3
Kingston, R.E.4
-
35
-
-
0030988941
-
Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation
-
Kline MP, Morimoto RI. 1997. Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17:2107-2115.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2107-2115
-
-
Kline, M.P.1
Morimoto, R.I.2
-
36
-
-
0032541032
-
Transcriptional activity of heat shock factor 1 at 37°C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Cα and Cζ
-
Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK. 1998. Transcriptional activity of heat shock factor 1 at 37°C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Cα and Cζ. J Biol Chem 273:18640-18646. http://dx.doi.org/10.1074/jbc.273.29.18640.
-
(1998)
J Biol Chem
, vol.273
, pp. 18640-18646
-
-
Chu, B.1
Zhong, R.2
Soncin, F.3
Stevenson, M.A.4
Calderwood, S.K.5
-
37
-
-
0036901003
-
Multisite phosphorylation provides sophisticated regulation of transcription factors
-
Holmberg CI, Tran SE, Eriksson JE, Sistonen L. 2002. Multisite phosphorylation provides sophisticated regulation of transcription factors. Trends Biochem Sci 27:619-627. http://dx.doi.org/10.1016/S0968-0004(02)02207-7.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 619-627
-
-
Holmberg, C.I.1
Tran, S.E.2
Eriksson, J.E.3
Sistonen, L.4
-
38
-
-
0031055277
-
Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active factor trimers
-
Xia W, Voellmy R. 1997. Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active factor trimers. J Biol Chem 272:4094-4102. http://dx.doi.org/10.1074/jbc.272.7.4094.
-
(1997)
J Biol Chem
, vol.272
, pp. 4094-4102
-
-
Xia, W.1
Voellmy, R.2
-
39
-
-
0030043401
-
Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation
-
Cotto JJ, Kline M, Morimoto RI. 1996. Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. J Biol Chem 271:3355-3358.
-
(1996)
J Biol Chem
, vol.271
, pp. 3355-3358
-
-
Cotto, J.J.1
Kline, M.2
Morimoto, R.I.3
-
40
-
-
17844386323
-
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
-
Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. 2001. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20:3800-3810. http://dx.doi.org/10.1093/emboj/20.14.3800.
-
(2001)
EMBO J
, vol.20
, pp. 3800-3810
-
-
Holmberg, C.I.1
Hietakangas, V.2
Mikhailov, A.3
Rantanen, J.O.4
Kallio, M.5
Meinander, A.6
Hellman, J.7
Morrice, N.8
MacKintosh, C.9
Morimoto, R.I.10
Eriksson, J.E.11
Sistonen, L.12
-
41
-
-
0036290246
-
Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia
-
Wang J, Yao M, Gu J, Sun L, Shen Y, Liu X. 2002. Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia. Biochem Biophys Res Commun 290:1454-1461. http://dx.doi.org/10.1006/bbrc.2002.6373.
-
(2002)
Biochem Biophys Res Commun
, vol.290
, pp. 1454-1461
-
-
Wang, J.1
Yao, M.2
Gu, J.3
Sun, L.4
Shen, Y.5
Liu, X.6
-
42
-
-
1642569697
-
DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity
-
Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R. 2004. DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci U S A 101:4100-4105. http://dx.doi.org/10.1073/pnas.0304768101.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4100-4105
-
-
Boellmann, F.1
Guettouche, T.2
Guo, Y.3
Fenna, M.4
Mnayer, L.5
Voellmy, R.6
-
43
-
-
67650410543
-
Biological and chemical approaches to diseases of proteostasis deficiency
-
Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. 2009. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 78:959-991. http://dx.doi.org/10.1146/annurev.biochem.052308.114844.
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 959-991
-
-
Powers, E.T.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
Balch, W.E.5
-
44
-
-
84874832163
-
Protein homeostasis as a therapeutic target for diseases of protein conformation
-
Calamini B, Morimoto RI. 2012. Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem 12: 2623-2640. http://dx.doi.org/10.2174/1568026611212220014.
-
(2012)
Curr Top Med Chem
, vol.12
, pp. 2623-2640
-
-
Calamini, B.1
Morimoto, R.I.2
-
45
-
-
25844466597
-
Heat shock response modulators as therapeutic tools for diseases of protein conformation
-
Westerheide SD, Morimoto RI. 2005. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 280: 33097-33100. http://dx.doi.org/10.1074/jbc.R500010200.
-
(2005)
J Biol Chem
, vol.280
, pp. 33097-33100
-
-
Westerheide, S.D.1
Morimoto, R.I.2
-
46
-
-
75749136948
-
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease
-
Neef DW, Turski ML, Thiele DJ. 2010. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol 8:e1000291. http://dx.doi.org/10.1371/journal.pbio.1000291.
-
(2010)
PLoS Biol
, vol.8
-
-
Neef, D.W.1
Turski, M.L.2
Thiele, D.J.3
-
47
-
-
84856089134
-
Small-molecule proteostasis regulators for protein conformational diseases
-
Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI. 2012. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol 8:185-196. http://dx.doi.org/10.1038/nchembio.763.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 185-196
-
-
Calamini, B.1
Silva, M.C.2
Madoux, F.3
Hutt, D.M.4
Khanna, S.5
Chalfant, M.A.6
Saldanha, S.A.7
Hodder, P.8
Tait, B.D.9
Garza, D.10
Balch, W.E.11
Morimoto, R.I.12
-
48
-
-
84867502093
-
Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise
-
West JD, Wang Y, Morano KA. 2012. Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol 25:2036-2053. http://dx.doi.org/10.1021/tx300264x.
-
(2012)
Chem Res Toxicol
, vol.25
, pp. 2036-2053
-
-
West, J.D.1
Wang, Y.2
Morano, K.A.3
-
49
-
-
0023697252
-
GAL4-VP16 is an unusually potent transcriptional activator
-
Sadowski I, Ma J, Triezenberg S, Ptashne M. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335:563-564. http://dx.doi.org/10.1038/335563a0.
-
(1988)
Nature
, vol.335
, pp. 563-564
-
-
Sadowski, I.1
Ma, J.2
Triezenberg, S.3
Ptashne, M.4
-
50
-
-
0023815651
-
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells
-
Mosser DD, Theodorakis NG, Morimoto RI. 1988. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol Cell Biol 8:4736-4744.
-
(1988)
Mol Cell Biol
, vol.8
, pp. 4736-4744
-
-
Mosser, D.D.1
Theodorakis, N.G.2
Morimoto, R.I.3
-
51
-
-
0033669588
-
Formation of nuclear HSF1 granules varies depending on stress stimuli
-
Holmberg CI, Illman SA, Kallio M, Mikhailov A, Sistonen L. 2000. Formation of nuclear HSF1 granules varies depending on stress stimuli. Cell Stress Chaperones 5:219-228. http://dx.doi.org/10.1379/1466-1268(2000)005<0219:FONHGV>2.0.CO;2.
-
(2000)
Cell Stress Chaperones
, vol.5
, pp. 219-228
-
-
Holmberg, C.I.1
Illman, S.A.2
Kallio, M.3
Mikhailov, A.4
Sistonen, L.5
-
52
-
-
84862520770
-
Fiji: an open-source platform for biological-image analysis
-
Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A. 2012. Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676-682. http://dx.doi.org/10.1038/nmeth.2019.
-
(2012)
Nat Methods
, vol.9
, pp. 676-682
-
-
Schindelin, J.1
Arganda-Carreras, I.2
Frise, E.3
Kaynig, V.4
Longair, M.5
Pietzsch, T.6
Preibisch, S.7
Rueden, C.8
Saalfeld, S.9
Schmid, B.10
Tinevez, J.Y.11
White, D.J.12
Hartenstein, V.13
Eliceiri, K.14
Tomancak, P.15
Cardona, A.16
-
53
-
-
0027461364
-
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress
-
Sarge KD, Murphy SP, Morimoto RI. 1993. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol 13:1392-1407.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 1392-1407
-
-
Sarge, K.D.1
Murphy, S.P.2
Morimoto, R.I.3
-
54
-
-
0027202187
-
Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase
-
Zhuo S, Clemens JC, Hakes DJ, Barford D, Dixon JE. 1993. Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase. J Biol Chem 268:17754-17761.
-
(1993)
J Biol Chem
, vol.268
, pp. 17754-17761
-
-
Zhuo, S.1
Clemens, J.C.2
Hakes, D.J.3
Barford, D.4
Dixon, J.E.5
-
56
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E, Anderson CW. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268:2764-2772. http://dx.doi.org/10.1046/j.1432-1327.2001.02225.x.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
57
-
-
0037075898
-
Activation of the p53 tumor suppressor protein
-
Vousden KH. 2002. Activation of the p53 tumor suppressor protein. Biochim Biophys Acta 1602:47-59. http://dx.doi.org/10.1016/S0304-419X(02)00035-5.
-
(2002)
Biochim Biophys Acta
, vol.1602
, pp. 47-59
-
-
Vousden, K.H.1
-
58
-
-
15044342095
-
Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells
-
Poizat C, Puri PL, Bai Y, Kedes L. 2005. Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol Cell Biol 25:2673-2687. http://dx.doi.org/10.1128/MCB.25.7.2673-2687.2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2673-2687
-
-
Poizat, C.1
Puri, P.L.2
Bai, Y.3
Kedes, L.4
-
59
-
-
0015216932
-
The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes
-
Obrig TG, Culp WJ, McKeehan WL, Hardesty B. 1971. The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J Biol Chem 246:174-181.
-
(1971)
J Biol Chem
, vol.246
, pp. 174-181
-
-
Obrig, T.G.1
Culp, W.J.2
McKeehan, W.L.3
Hardesty, B.4
-
60
-
-
0031841818
-
Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway
-
Mathew A, Mathur SK, Morimoto RI. 1998. Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol 18:5091-5098.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5091-5098
-
-
Mathew, A.1
Mathur, S.K.2
Morimoto, R.I.3
-
61
-
-
79953699778
-
Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress
-
Ahlskog JK, Björk JK, Elsing AN, Aspelin C, Kallio M, Roos-Mattjus P, Sistonen L. 2010. Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol 30:5608-5620. http://dx.doi.org/10.1128/MCB.01506-09.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5608-5620
-
-
Ahlskog, J.K.1
Björk, J.K.2
Elsing, A.N.3
Aspelin, C.4
Kallio, M.5
Roos-Mattjus, P.6
Sistonen, L.7
-
62
-
-
0031467707
-
HSF1 granules: a novel stressinduced nuclear compartment of human cells
-
Cotto J, Fox S, Morimoto RI. 1997. HSF1 granules: a novel stressinduced nuclear compartment of human cells. J Cell Sci 110:2925-2934.
-
(1997)
J Cell Sci
, vol.110
, pp. 2925-2934
-
-
Cotto, J.1
Fox, S.2
Morimoto, R.I.3
-
63
-
-
0031452176
-
HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites
-
Jolly C, Morimoto RI, Robert-Nicoud M, Vourc'h C. 1997. HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites. J Cell Sci 110:2935-2941.
-
(1997)
J Cell Sci
, vol.110
, pp. 2935-2941
-
-
Jolly, C.1
Morimoto, R.I.2
Robert-Nicoud, M.3
Vourc'h, C.4
-
64
-
-
0041468990
-
Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1
-
Wang X, Grammatikakis N, Siganou A, Calderwood SK. 2003. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol 23:6013-6026. http://dx.doi.org/10.1128/MCB.23.17.6013-6026.2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6013-6026
-
-
Wang, X.1
Grammatikakis, N.2
Siganou, A.3
Calderwood, S.K.4
-
65
-
-
78649721996
-
Protein kinase A binds and activates heat shock factor 1
-
Murshid A, Chou S, Prince T, Zhang Y, Bharti A, Calderwood SK. 2010. Protein kinase A binds and activates heat shock factor 1. PLoS One 5:e13830. http://dx.doi.org/10.1371/journal.pone.0013830.
-
(2010)
PLoS One
, vol.5
-
-
Murshid, A.1
Chou, S.2
Prince, T.3
Zhang, Y.4
Bharti, A.5
Calderwood, S.K.6
-
67
-
-
0041827383
-
Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70
-
Alastalo TP, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L. 2003. Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. J Cell Sci 116:3557-3570. http://dx.doi.org/10.1242/jcs.00671.
-
(2003)
J Cell Sci
, vol.116
, pp. 3557-3570
-
-
Alastalo, T.P.1
Hellesuo, M.2
Sandqvist, A.3
Hietakangas, V.4
Kallio, M.5
Sistonen, L.6
-
68
-
-
0032967906
-
Differential metal response and regulation of human heavy metal-inducible genes
-
Murata M, Gong P, Suzuki K, Koizumi S. 1999. Differential metal response and regulation of human heavy metal-inducible genes. J Cell Physiol 180:105-113. http://dx.doi.org/10.1002/(SICI)1097-4652(199907)180:1<105::AID-JCP12>3.0.CO;2-5.
-
(1999)
J Cell Physiol
, vol.180
, pp. 105-113
-
-
Murata, M.1
Gong, P.2
Suzuki, K.3
Koizumi, S.4
-
69
-
-
0742306280
-
Kinetics study of endogenous heat shock protein 70 expression
-
Wang S, Diller KR, Aggarwal SJ. 2003. Kinetics study of endogenous heat shock protein 70 expression. J Biomech Eng 125:794-797. http://dx.doi.org/10.1115/1.1632522.
-
(2003)
J Biomech Eng
, vol.125
, pp. 794-797
-
-
Wang, S.1
Diller, K.R.2
Aggarwal, S.J.3
-
70
-
-
80053359794
-
Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
-
Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A. 2011. Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Mol Biol Cell 22:3571-3583. http://dx.doi.org/10.1091/mbc.E11-04-0330.
-
(2011)
Mol Biol Cell
, vol.22
, pp. 3571-3583
-
-
Shinkawa, T.1
Tan, K.2
Fujimoto, M.3
Hayashida, N.4
Yamamoto, K.5
Takaki, E.6
Takii, R.7
Prakasam, R.8
Inouye, S.9
Mezger, V.10
Nakai, A.11
-
71
-
-
84932607499
-
HSF1 regulation of beta-catenin in mammary cancer cells through control of HuR/elavL1 expression
-
Chou SD, Murshid A, Eguchi T, Gong J, Calderwood SK. 2015. HSF1 regulation of beta-catenin in mammary cancer cells through control of HuR/elavL1 expression. Oncogene 34:2178-2188. http://dx.doi.org/10.1038/onc.2014.177.
-
(2015)
Oncogene
, vol.34
, pp. 2178-2188
-
-
Chou, S.D.1
Murshid, A.2
Eguchi, T.3
Gong, J.4
Calderwood, S.K.5
-
72
-
-
84899754421
-
The proteasome inhibitor bortezomib is a potent inducer of zinc-finger AN1-type domain 2a gene expression: role of HSF1/HSF2 heterocomplexes
-
Rossi A, Riccio A, Coccia M, Trotta E, La Frazia S, Santoro MG. 2014. The proteasome inhibitor bortezomib is a potent inducer of zinc-finger AN1-type domain 2a gene expression: role of HSF1/HSF2 heterocomplexes. J Biol Chem 289:12705-12715. http://dx.doi.org/10.1074/jbc.M113.513242.
-
(2014)
J Biol Chem
, vol.289
, pp. 12705-12715
-
-
Rossi, A.1
Riccio, A.2
Coccia, M.3
Trotta, E.4
La Frazia, S.5
Santoro, M.G.6
-
73
-
-
84905404620
-
Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome
-
El Fatimy R, Miozzo F, Le Mouel A, Abane R, Schwendimann L, Saberan-Djoneidi D, de Thonel A, Massaoudi I, Paslaru L, Hashimoto-Torii K, Christians E, Rakic P, Gressens P, Mezger V. 2014. Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome. EMBO Mol Med 6:1043-1061. http://dx.doi.org/10.15252/emmm.201303311.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 1043-1061
-
-
El Fatimy, R.1
Miozzo, F.2
Le Mouel, A.3
Abane, R.4
Schwendimann, L.5
Saberan-Djoneidi, D.6
de Thonel, A.7
Massaoudi, I.8
Paslaru, L.9
Hashimoto-Torii, K.10
Christians, E.11
Rakic, P.12
Gressens, P.13
Mezger, V.14
-
74
-
-
84907076634
-
Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival
-
Elsing AN, Aspelin C, Björk JK, Bergman HA, Himanen SV, Kallio MJ, Roos-Mattjus P, Sistonen L. 2014. Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. J Cell Biol 206:735-749. http://dx.doi.org/10.1083/jcb.201402002.
-
(2014)
J Cell Biol
, vol.206
, pp. 735-749
-
-
Elsing, A.N.1
Aspelin, C.2
Björk, J.K.3
Bergman, H.A.4
Himanen, S.V.5
Kallio, M.J.6
Roos-Mattjus, P.7
Sistonen, L.8
-
75
-
-
0026636883
-
The regulation of transcription by phosphorylation
-
Hunter T, Karin M. 1992. The regulation of transcription by phosphorylation. Cell 70:375-387. http://dx.doi.org/10.1016/0092-8674(92)90162-6.
-
(1992)
Cell
, vol.70
, pp. 375-387
-
-
Hunter, T.1
Karin, M.2
-
76
-
-
0024290703
-
Structural changes in glycogen phosphorylase induced by phosphorylation
-
Sprang S, Acharya K, Goldsmith E, Stuart D, Varvill K, Fletterick R, Madsen N, Johnson L. 1988. Structural changes in glycogen phosphorylase induced by phosphorylation. Nature 336:215-221. http://dx.doi.org/10.1038/336215a0.
-
(1988)
Nature
, vol.336
, pp. 215-221
-
-
Sprang, S.1
Acharya, K.2
Goldsmith, E.3
Stuart, D.4
Varvill, K.5
Fletterick, R.6
Madsen, N.7
Johnson, L.8
-
77
-
-
0025032116
-
Regulation of an enzyme by phosphorylation at the active site
-
Hurley JH, Dean AM, Sohl JL, Koshland DE, Jr, Stroud RM. 1990. Regulation of an enzyme by phosphorylation at the active site. Science 249:1012-1016. http://dx.doi.org/10.1126/science.2204109.
-
(1990)
Science
, vol.249
, pp. 1012-1016
-
-
Hurley, J.H.1
Dean, A.M.2
Sohl, J.L.3
Koshland, D.E.4
Stroud, R.M.5
-
78
-
-
0038623298
-
Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation
-
Corey LL, Weirich CS, Benjamin IJ, Kingston RE. 2003. Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. Genes Dev 17:1392-1401. http://dx.doi.org/10.1101/gad.1071803.
-
(2003)
Genes Dev
, vol.17
, pp. 1392-1401
-
-
Corey, L.L.1
Weirich, C.S.2
Benjamin, I.J.3
Kingston, R.E.4
-
79
-
-
0034881496
-
Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
-
Park JM, Werner J, Kim JM, Lis JT, Kim Y. 2001. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Mol Cell 8:9-19. http://dx.doi.org/10.1016/S1097-2765(01)00296-9.
-
(2001)
Mol Cell
, vol.8
, pp. 9-19
-
-
Park, J.M.1
Werner, J.2
Kim, J.M.3
Lis, J.T.4
Kim, Y.5
-
80
-
-
0033664085
-
Potential targets for HSF1 within the preinitiation complex
-
Yuan C, Gurley WB. 2000. Potential targets for HSF1 within the preinitiation complex. Cell Stress Chaperones 5:229-242. http://dx.doi.org/10.1379/1466-1268(2000)005<0229:PTFHWT>2.0.CO;2.
-
(2000)
Cell Stress Chaperones
, vol.5
, pp. 229-242
-
-
Yuan, C.1
Gurley, W.B.2
-
81
-
-
84868088016
-
RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT
-
Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A. 2012. RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT. Mol Cell 48:182-194. http://dx.doi.org/10.1016/j.molcel.2012.07.026.
-
(2012)
Mol Cell
, vol.48
, pp. 182-194
-
-
Fujimoto, M.1
Takaki, E.2
Takii, R.3
Tan, K.4
Prakasam, R.5
Hayashida, N.6
Iemura, S.7
Natsume, T.8
Nakai, A.9
-
82
-
-
84895077483
-
Regulation of transcription factor activity by interconnected posttranslational modifications
-
Filtz TM, Vogel WK, Leid M. 2014. Regulation of transcription factor activity by interconnected posttranslational modifications. Trends Pharmacol Sci 35:76-85. http://dx.doi.org/10.1016/j.tips.2013.11.005.
-
(2014)
Trends Pharmacol Sci
, vol.35
, pp. 76-85
-
-
Filtz, T.M.1
Vogel, W.K.2
Leid, M.3
-
83
-
-
45749100074
-
Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1
-
Singleton KD, Wischmeyer PE. 2008. Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. J Parent Enteral Nutr 32:371-376. http://dx.doi.org/10.1177/0148607108320661.
-
(2008)
J Parent Enteral Nutr
, vol.32
, pp. 371-376
-
-
Singleton, K.D.1
Wischmeyer, P.E.2
|