Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure

Journal of Molecular and Cellular Cardiology

Volumn 96, Issue , 2016, Pages 82-92

  Holzem, Katherine M ^a   Gomez, Juan F ^b   Glukhov, Alexey V ^a   Madden, Eli J ^a   Koppel, Aaron C ^a   Ewald, Gregory A ^a   Trenor, Beatriz ^b   Efimov, Igor R ^a,c  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^c MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

Author keywords

Arrhythmias; Heart failure; Potassium channels; Remodeling; Repolarization

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; DELAYED RECTIFIER POTASSIUM CHANNEL; HERG1A PROTEIN; HERG1B PROTEIN; ISOPROTEIN; UNCLASSIFIED DRUG; ANTIARRHYTHMIC AGENT; KCNH2 PROTEIN, HUMAN; PIPERIDINE DERIVATIVE; POTASSIUM; POTASSIUM CHANNEL HERG; PYRIDINE DERIVATIVE;

ACTION POTENTIAL DURATION; ADOLESCENT; ADULT; AGED; ARTICLE; CARDIAC MUSCLE; COMPUTER SIMULATION; CONTROLLED STUDY; DONOR; DOWN REGULATION; ENDOCARDIUM; EPICARDIUM; FEMALE; GENE; GENE EXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE; HEART REPOLARIZATION; HEART VENTRICLE REMODELING; HERG1A GENE; HERG1B GENE; HUMAN; HUMAN TISSUE; MALE; MID MYOCARDIUM; MIDDLE AGED; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOICHIOMETRY; WESTERN BLOTTING; ACTION POTENTIAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; GENETICS; HEART VENTRICLE; METABOLISM; PATHOPHYSIOLOGY; YOUNG ADULT;

ACTION POTENTIALS; ADOLESCENT; ADULT; ANTI-ARRHYTHMIA AGENTS; COMPUTER SIMULATION; ERG1 POTASSIUM CHANNEL; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MYOCARDIUM; PIPERIDINES; POTASSIUM; PYRIDINES; YOUNG ADULT;

EID: 84932121455     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.06.008     Document Type: Article

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