mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Walmsley, John ^a   Rodriguez, Jose F ^b,c   Mirams, Gary R ^a   Burrage, Kevin ^a,d   Efimov, Igor R ^e   Rodriguez, Blanca ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MESSENGER RNA;

ACTION POTENTIAL; ARTICLE; CALCIUM TRANSPORT; CELL POPULATION; CONTROLLED STUDY; DOWN REGULATION; EPICARDIUM; GENETIC TRANSCRIPTION; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; PERICARDIUM; POPULATION RESEARCH; PROTEIN EXPRESSION; SIMULATION; UPREGULATION;

ACTION POTENTIALS; BIOLOGICAL MARKERS; CALCIUM SIGNALING; COMPUTER SIMULATION; ELECTROPHYSIOLOGICAL PHENOMENA; GENE EXPRESSION REGULATION; HEART FAILURE; HUMANS; REGRESSION ANALYSIS; RNA, MESSENGER; VENTRICULAR REMODELING;

EID: 84874236004     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056359     Document Type: Article

References (40)

1. Gaborit N, Varró A, Le Boulter S, Szuts V, Escande D, et al. (2010) Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts. J Mol Cell Cardiol 49: 639-646.
2. Soltysinska E, Olesen S, Christ T, Wettwer E, Varró A, et al. (2009) Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pugers Arch 459: 11-23.
3. Ambrosi C, Yamada K, Nerbonne J, Efimov I, (2013) Gender differences in electrophysiological gene expression in failing and nonfailing human hearts. PLOS ONE 8(1): e54635 doi:10.1371/journal.pone.0054635.
4. Glukhov A, Fedorov V, Lou Q, Ravikumar V, Kalish P, et al. (2010) Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res 106: 1-11.
5. Lou Q, Fedorov V, Glukhov A, Moazami N, Fast V, et al. (2011) Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure. Circulation 123: 1881-1890.
6. Glukhov A, Fedorov V, Lou Q, Janks D, Ravikumar V, et al. (2012) Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation 125: 1835-1847.
7. Tomaselli G, Márban E, (1999) Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42: 270-283.
8. Tomaselli G, Zipes D, (2004) What causes sudden death in heart failure? Circ Res 95: 754-763.
9. Nattel S, Maguy A, Le Boulter S, Yeh YH, (2007) Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 87: 425-456.
10. Cutler M, Jeyaraj D, Rosenbaum D, (2011) Cardiac electrical remodeling in health and disease. Trends Pharmacol Sci 32: 174-180.
11. Nattel S, Frelin Y, Gaborit N, Loualt C, Demolombe S, (2010) Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates. J Mol Cell Cardiol 48: 96-105.
12. Bray M, Shaw C, Moore M, Garcia R, Zanquetta M, et al. (2008) Disruption of the circadian clock within the cardiomyocyte inuences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol 294: H1036-H1047.
13. Jeyaraj D, Haldar S, Wan X, McCauley M, Ripperger J, et al. (2012) Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 483: 96-99.
14. James A, Choisy S, Hancox J, (2007) Recent advances in understanding sex differences in cardiac repolarization. Prog Biophys Mol Bio 94: 265-319.
15. O'Hara T, Virág L, Varró A, Rudy Y, (2011) Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation. PLOS Comput Biol 7: e1002061.
16. Romero L, Pueyo E, Fink M, Rodríguez B, (2009) Impact of ionic current variability on human ventricular cellular electrophysiology. Am J Physiol Heart Circ Physiol 297: H1436-H1445.
17. Sarkar A, Sobie E, (2011) Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis. Heart Rhythm 8: 1749-1755.
18. Pueyo E, Corrias A, Virág L, Jost N, Szél T, et al. (2011) A multi-scale investigation of repolar-ization variability and its role in cardiac arrhythmogenesis. Biophys J 101: 2892-2902.
19. Rodríguez J, Carro Fernandez J, Pueyo E, Burrage K, Rodríguez B, (2012) Impact of multiple ionic changes in arrhythmic risk biomarkers in human ventricular electrophysiology. Biophys J 102: 543a.
20. Sarkar A, Christini D, Sobie E, (2012) Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol 590: 2555-2567.
21. Sobie E, (2009) Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J 96: 1264-1274.
22. Sarkar A, Sobie E, (2010) Regression analysis for constraining free parameters in electrophysiological models of cardiac cells. PLOS Comput Biol 6: e1000914.
23. Pitt-Francis J, Pathmanathan P, Bernabeu M, Bordas R, Cooper J, et al. (2009) Chaste: A test-driven approach to software development for biological modelling. Comp Phys Commun 180: 2452-2471.
24. Lloyd C, Lawson J, Hunter P, Nielsen P, (2008) The CellML model repository. Bioinformatics 24: 2122-2123.
25. Cooper J, Mirams G, Niederer S, (2011) High-throughput functional curation of cellular electro-physiology models. Prog Biophys Mol Bio 107: 11-20.
26. Sipido K, Stankovica T, Flameng W, Vanhaecke J, Verdonck F, (1998) Frequency dependence of Ca2+ release from the sarcoplasmic reticulum in human ventricular myocytes from end-stage heart failure. Cardiovasc Res 37: 478-488.
27. Li G, Lau C, Leung T, Nattel S, (2004) Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 4: 460-468.
28. Beuckelmann D, Nabauer M, Erdmann E, (1992) Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 85: 1046-1055.
29. Beuckelmann D, Nabauer M, Erdmann E, (1993) Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 379-385.
30. Priebe L, Beuckelmann D, (1998) Simulation study of cellular electric properties in heart failure. Circ Res 82: 1206-1223.
31. Vahl C, Bonz A, Timek T, Hagl S, (1994) Intracellular calcium transient of working human myocardium of seven patients transplanted for congestive heart failure. Circ Res 74: 952-958.
32. Kubo H, Marguiles K, Piacentino III V, Gaughan J, Houser S, (2001) Patients with end-stage congestive heart failure treated with β-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation 104: 1012-1018.
33. Piacentino III V, Weber C, Chen X, Weisser-Thomas J, Marguiles K, et al. (2003) Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res 92: 651-658.
34. Gwathmey G, Copelas L, MacKinnon R, Schoen F, Feldman M, et al. (1987) Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 61: 70-76.
35. Trenor B, Cardona K, Gomez J, Rajamani S, Ferrero Jr J, et al. (2012) Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure. PLOS ONE 7: e32659.
36. Quinn T, Granite S, Allessie M, Antzelevitch C, Bollensdorff C, et al. (2011) Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol 10: 4-10.
37. Carusi A, Burrage K, Rodríguez B, (2012) Bridging experiments, models and simulations: An integrative approach to validation in computational cardiac electrophysiology. Am J Physiol Heart Circ Physiol 303: H144-H155.
38. Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H, (1995) Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells. J Am Coll Cardiol 26: 185-192.
39. Schroder F, Handrock R, Beuckelmann D, Hirt S, Hullin R, et al. (1998) Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle. Circulation 98: 969-976.
40. Thomsen M, Wang C, Ozgen N, Wang H, Rosen M, et al. (2009) Accessory subunit KChIP2 modulates the cardiac L-type calcium current. Circ Res 104: 1382-389.