Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. a computer modeling study

IEEE Transactions on Biomedical Engineering

Volumn 58, Issue 1, 2011, Pages 43-53

  Saiz, Javier ^a   Gomis Tena, Julio ^a   Monserrat, Marta ^a   Ferrero, Jose M ^a   Cardona, Karen ^a   Chorro, Javier ^b  

^a UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Action potential duration (APD) heterogeneity; antiarrhythmic drug; beat to beat instability; dofetilide model; drug I Kr interaction model; EADs; guarded receptor theory

Indexed keywords

ACTION POTENTIAL DURATIONS; ANTIARRHYTHMIC DRUG; BEAT-TO-BEAT INSTABILITY; DOFETILIDE; DRUG - I KR INTERACTION MODEL; EADS; GUARDED RECEPTOR THEORY;

ELECTROPHYSIOLOGY; MATHEMATICAL MODELS; POTASSIUM; TEACHING;

DISPERSIONS;

DOFETILIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DISPERSION; DRUG BINDING; DRUG EFFECT; ENDOCARDIUM; EPICARDIUM; GUINEA PIG; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE; INHIBITION KINETICS; MATHEMATICAL MODEL; MEMBRANE POTENTIAL; MODEL; NONHUMAN; STEADY STATE; VOLTAGE CLAMP;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CELLS, CULTURED; COMPUTER SIMULATION; GUINEA PIGS; HEART; HEART VENTRICLES; MODELS, CARDIOVASCULAR; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; SULFONAMIDES;

EID: 79551543902     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBME.2010.2077292     Document Type: Article

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