Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?

Neurology

Volumn 46, Issue 3, 1996, Pages 641-650

  Lautenschlager, N T ^a   Cupples, L A ^a   Rao, V S ^a   Auerbach, S A ^a   Becker, R ^b   Burke, J ^c   Chui, H ^d   Duara, R ^e   Foley, E J ^a   Glatt, S L ^f   Green, R C ^g   Jones, R ^g   Karlinsky, H ^h   Kukull, W A ^b   Kurz, A ⁱ   Larson, E B ^b   Martelli, K ^d   Sadovnick, A D ^j   Volicer, L ^k   Waring, S C ^l   Growdon, J H ^m   Farrer, L A ^a,m   more..

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Riverview Hospital   (Canada)

ⁱ TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^j UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^k VETERANS AFFAIRS MEDICAL CENTER   (United States)

^l MAYO CLINIC   (United States)

^m HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEMENTIA; FEMALE; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PATIENT COUNSELING; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 9044228404     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.46.3.641     Document Type: Article

References (74)

1. Katzman A. The prevalence and malignancy of Alzheimer disease: a major killer. Arch Neurol 1976;33:217-218.
2. Martin DC, Miller JK, Kapoor W, Arena VC, Boller F. A controlled study of survival with dementia. Arch Neurol 1987; 44:1122-1126.
3. Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer's disease in a community population of older persons. JAMA 1989;262:2551-2556.
4. Mullan M, Crawford F, Buchanan J. Technical feasibility of genetic testing for Alzheimer's disease. Alzheimer Dis Assoc Disord 1994;8:102-115.
5. Barclay LL, Zemcov A, Blass JP, et al. Survival in Alzheimer's disease and vascular dementias. Neurology 1985;35:835-840.
6. Diesfeldt HFA, van Hotte LR, Moerkens RM. Duration of survival in senile dementia. Acta Psychiatr Scand 1986;73:366-371.
7. St. George-Hyslop PH, Myers RH, Haines JL, et al. Familial Alzheimer's disease: progress and problems. Neurobiol Aging 1989;10:417-425.
8. Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-760.
9. Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-977.
10. Goate A, Chartier-Harlin M-C, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-706.
11. Mullan M, Crawford F, Houlden H, et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene of the N-terminus of beta-amyloid. Nat Genet 1992;2:345-347.
12. Chartier-Harlin M-C, Crawford F, Mullan M, et al. Early-onset Alzheimer's disease caused by mutation at codon 717 of the beta-amyloid precursor protein gene. Nature 1991;353: 844-846.
13. Murell J, Farlow M, Ghetti B, Benson MD. A mutation in the amyloid precursor protein associated with hereditary Alzheimer disease. Science 1991;254:97-99.
14. Pericak-Vance MA, Bebout JL, Gaskell PC Jr, et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991;48:1034-1050.
15. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993;90:1977-1981.
16. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
17. van Duijn CM, de Knijff P, Wehnert A, Havekers LM, Hofman A, van Broeckhoven C. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet 1994;7:74-78.
18. Chartier-Harlin MC, Parfitt M, Legrain S, et al. Apolipoprotein E, ∈4-allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum Mol Genet 1994;3:569-574.
19. Nalbantoglu J, Gilfix BM, Bertrand P, Robitaille Y, et al. Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies. Ann Neurol 1994;36:889-895.
20. Kuusisto J, Koivisto K, Kervinen Mykkänen L, et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ 1994;309:636-638.
21. Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interaction of apolipoprotein E genotype, total cholesterol level, and sex in prediction of Alzheimer disease in a case-control study. Neurology 1995;45:1092-1096.
22. Myers RH, Schaefer EJ, Wilson PWF, et al. Apolipoprotein E allele 4 is associated with dementia in a population based study: the Framingham Study. Neurology 1995. In press.
23. Roses AD. Apolipoprotein E affects the rate of Alzheimer disease expression: βamyloid burden is a secondary consequence dependent on ApoE genotype and duration of disease. J Neuropathol Exp Neurol 1994;53:429-437.
24. Corder EH, Saunders AM, Risch NJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
25. Borgaonkar DS, Schmidt LC, Martin SE, et al. Linkage of late-onset Alzheimer disease with apolipoprotein E type 4 on chromosome 19. Lancet 1993;342:625.
26. van Gool WA, Hijdra A. Diagnosis of Alzheimer's disease by apolipoprotein E genotyping. Lancet 1994;344:275.
27. Mayeux R, Ottman R, Maestre G, et al. Synergistic effects of traumatic head injury and apolipoprotein-∈4 in patients with Alzheimer's disease. Neurology 1995;45:555-557.
28. Farrer LA, Cupples LA, van Duijn CM, et al. ApoE genotype in patients with Alzheimer disease: implications for the risk of dementia among relatives. Ann Neurol 1995;38:797-808.
29. Rao VS, van Duijn CM, Connor-Lacke L, Cupples LA, Growdon JH, Farrer LA. Multiple etiologies for Alzheimer disease are revealed by segregation analysis. Am J Hum Genet 1994; 55:991-1000.
30. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Statist Assoc 1958;53:457-481.
31. Chase GA, Folstein MF, Breitner JCS, Beaty TH, Self SG. The use of life tables and survival analysis in testing genetic hypotheses, with an application to Alzheimer's disease. Am J Epidemiol 1983;117:590-597.
32. Cupples LA, Terrin NC, Myers RH, D'Agostino RB. Using survival methods to estimate age at onset distribution for genetic disease with an application to Huntington's disease. Genet Epidemiol 1989;6:361-371.
33. Cupples LA, Risch N, Farrer LA, Myers RH. Estimation of age at onset with missing information of onset. Am J Hum Genet 1991;49:76-87.
34. Breitner JCS, Folstein MF. Familial Alzheimer dementia: a prevalent disorder with specific clinical features. Psychol Med 1984;14:63-80.
35. Breitner JCS, Murphy EA, Folstein MF. Familial aggregation in Alzheimer dementia: II. Clinical genetic implications of age dependent onset. J Psychiatr Res 1986;20:45-55.
36. Breitner JCS, Silverman JM, Mohs RC, Davis KL. Familial aggregation in Alzheimer's disease: comparison of risk among relatives of early- and late-onset cases, and among male and female relatives in successive generations. Neurology 1988;38: 207-212.
37. Mohs CR, Breitner JCS, Silverman JM, Davis KL. Alzheimer's disease, morbid risk among first-degree relatives approximates 50% by 90 years of age. Arch Gen Psychiatry 1987; 44:405-408.
38. Huff FJ, Auerbach J, Chakravarti A, Boller F. Risk of dementia in relatives of patients with Alzheimer's disease. Neurology 1988;38:786-790.
39. Martin RL, Gerteis G, Gabrielli WF. A family-genetic study of dementia of Alzheimer type. Arch Gen Psychiatry 1988;45: 894-900.
40. Farrer LA, O'Sullivan DM, Cupples A, Growdon JH, Myers RH. Assessment of genetic risk for Alzheimer's disease among first-degree relatives. Ann Neurol 1989;25:485-493.
41. Sadovnick AD, Irwin ME, Baird PA, Beattie BL. Genetic studies on an Alzheimer clinic population. Genet Epidemiol 1989; 6:633-643.
42. van Duijn CM, Farrer LA, Cupples LA, Hofman A. Genetic transmission for Alzheimer's disease among patients identified in a Dutch population based survey. J Med Genet 1993; 30:640-646.
43. Hirst C, Yee IML, Sadovnick AD. Familial risk for Alzheimer's disease from a population-based series. Genet Epidemiol 1994;11:365-374.
44. Farrer LA, Cupples LA, Blackburn S, et al. Interrater agreement for diagnosis of Alzheimer's disease: the MIRAGE study. Neurology 1994;44:652-656.
45. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-945.
46. Rao VS, Cupples LA, Auerbach SA, et al. Age at onset of Alzheimer disease is influenced by multiple genetic and non-genetic factors: the MIRAGE Study. Alzheimer Research 1995;1:159-167.
47. Swokowski EW. Calculus with analytical geometry. Boston, MA: Prindle, Weber and Schmidt, 1977.
48. Sokal RR, Rohlf FJ. Biometry. San Francisco: W.H. Freeman, 1981.
49. Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data. New York: Wiley, 1980.
50. Schoenberg BS, Kokmen E, Okazaki H. Alzheimer's disease and other dementing illnesses in a defined United States population: incidence rates and clinical features. Ann Neurol 1987;22:724-729.
51. Bird TD, Nemens EJ, Kukull WA. Conjugal Alzheimer's disease: is there an increased risk in offspring? Ann Neurol 1993; 34:396-399.
52. Mayeux R, Sano M, Chen J, Tatemichi T, Stern Y. Risk of dementia in first-degree relatives of patients with Alzheimer's disease and related disorders. Arch Neurol 1991;48:269-273.
53. Payami H, Montee K, Kaye J. Evidence for familial factors that protect against dementia and outweigh the effect of increasing age. Am J Hum Genet 1994;54:650-657.
54. Silverman JM, Li G, Zaccario ML, et al. Patterns of risk in first degree relatives of Alzheimer's disease patients. Arch Gen Psychiatry 1994;51:577-586.
55. Kay DWK, Beamish P, Roth M. Old age mental disorders in Newcastle upon Tyne. Br J Psychiatry 1964;110:146-158.
56. Treves T, Korczyn AD, Zilber N. Presenile dementia in Israel. Arch Neurol 1986;43:26-29.
57. Breitner JCS, Gau BA, Welsh KA, et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study. Neurology 1994;44:227-232.
58. Paganini-Hill A, Henderson VW. Estrogen deficiency and risk of Alzheimer's disease in women. Am J Epidemiol 1994;140: 256-261.
59. Heston LL, Maestri AR, Anderson VE, White J. Dementia of the Alzheimer type. Arch Gen Psychiatry 1981;38:1085-1090.
60. Li G, Silverman JM, Smith CJ, et al. Age at onset and familial risk in Alzheimer's disease. Am J Psychiatry 1995;152:424-430.
61. Farrer LA, Myers RH, Cupples LA, et al. Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity. Neurology 1990;40:395-403.
62. Locke PA, Conneally RE, Tanzi RE, Gusella JF, Haines JL. Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early-and late-onset cases. Genet Epidemiol 1995;12:83-92.
63. Wernicke TF, Reischies FM. Prevalence of dementia in old age: clinical diagnoses in subjects aged 95 years and older. Neurology 1994;44:250-253.
64. Ebly EM, Parhad IM, Hogan DB, Fung TS. Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging. Neurology 1994;44:1593-1600.
65. Drachman DA. If we live long enough will we all be demented? Neurology 1994;44:1563-1565.
66. Hagnell O, Öjesjö L, Rorsman B. Incidence of dementia in the Lundby study. Neuroepidemiology 1992;11(Suppl 1):61-66.
67. Bachman DL, Wolf PA, Linn RT, et al. Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study. Neurology 1993;43:515-519.
68. Roses AD. Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease. Ann Neurol 1995;38:6-14.
69. Berg L. Does Alzheimer's disease represent an exaggeration of normal aging? Arch Neurol 1985;42:737-739.
70. Farrer LA. Neurogenetics of aging. In: Albert ML, Knoefel JE, eds. Clinical neurology of aging. 2nd ed. New York: Oxford Univ Press, 1994:136-155.
71. Silverman JM, Breitner JC, Mohs RC, Davis KL. Reliability of the family history method in genetic studies of Alzheimer's disease and related dementias. Am J Psychiatry 1986; 143:1279-1282.
72. Breitner JCS, Magruder-Habib KM. Criteria for onset critically influence the estimation of familial risk in Alzheimer's disease. Genet Epidemiol 1989;6:663-669.
73. Bird TD. Apolipoprotein E genotyping in the diagnosis of Alzheimer's disease: a cautionary view (editorial). Ann Neurol 1995;38:2-3.
74. Farrer LA, Brin M, Elsas L, et al. Statement on use of apolipoprotein E testing for Alzheimer disease. JAMA 1995;274: 1627-1629.