Why selection might be stronger when populations are small: Intron size and density predict within and between-species usage of exonic splice associated cis-motifs

Molecular Biology and Evolution

Volumn 32, Issue 7, 2015, Pages 1847-1861

  Wu, XianMing ^a   Hurst, Laurence D ^a  

^a University of Bath   (United Kingdom)

Author keywords

exonic splice enhancer; intron density; purifying selection; synonymous mutation

Indexed keywords

MICRORNA; SERINE ARGININE RICH PROTEIN; TRANSFER RNA; AMINO ACID; CODON;

ALTERNATIVE RNA SPLICING; ARTICLE; CIS MOTIF; CODON; CODON USAGE; CONTROLLED STUDY; EFFECTIVE POPULATION SIZE; ENHANCER REGION; EXON; GENE FUNCTION; GENETIC SELECTION; GENETIC VARIABILITY; GENOME; GENOME SIZE; GOLD STANDARD; HUMAN; HUMAN GENOME; INTRON; MACAQUE MODEL; MUTATION RATE; NONHUMAN; PHYLOGENETIC TREE; PHYLOGENY; POPULATION SIZE; PURIFYING SELECTION; RANDOMIZED CONTROLLED TRIAL; RNA SPLICING; SEQUENCE ALIGNMENT; SPECIES DIFFERENCE; STOP CODON; TRANSCRIPTION ELONGATION; ANIMAL; GENETICS; MOLECULAR EVOLUTION; MUTATION; NONPARAMETRIC TEST; NUCLEOTIDE MOTIF;

ALTERNATIVE SPLICING; AMINO ACIDS; ANIMALS; CODON; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; EXONS; HUMANS; INTRONS; MUTATION; NUCLEOTIDE MOTIFS; PHYLOGENY; RNA SPLICING; SELECTION, GENETIC; SPECIES SPECIFICITY; STATISTICS, NONPARAMETRIC;

EID: 84931289173     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msv069     Document Type: Article

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