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Volumn 12, Issue 6, 2002, Pages 640-649

Evolution of synonymous codon usage in metazoans

Author keywords

[No Author keywords available]

Indexed keywords

CODON USAGE; DROSOPHILA; DROSOPHILA ELEGANS; GENE CONVERSION; GENE MUTATION; GENE TARGETING; METAZOON; MOLECULAR EVOLUTION; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; VERTEBRATE; ANIMAL; CAENORHABDITIS ELEGANS; GENETIC CODE; GENETIC SELECTION; GENETICS; RODENT;

EID: 0036889468     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00353-2     Document Type: Review
Times cited : (409)

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    • Integrating genomics, bioinformatics, and classical genetics to study the effects of recombination on genome evolution
    • This paper shows that in yeast the GC content at silent sites is correlated positively with recombination rate. Neither selection nor mutation can explain this correlation. In agreement with a similar analysis in mammals [47•], the author concludes that this correlation results from biased gene conversion (BGC). In many taxa (including yeast and mammals), the repair of DNA mismatches is biased toward GC, which probably corresponds to an evolutionary adaptation to a universal mutational bias towards AT. In recombining genomes, this bias in mismatch repair will lead to gene conversion biases. Together with [47•], this paper highlights the importance of taking into account BGC in models of population genetics.
    • Birdsell J.A. Integrating genomics, bioinformatics, and classical genetics to study the effects of recombination on genome evolution. Mol Biol Evol. 19:2002;1181-1197. This paper shows that in yeast the GC content at silent sites is correlated positively with recombination rate. Neither selection nor mutation can explain this correlation. In agreement with a similar analysis in mammals [47•], the author concludes that this correlation results from biased gene conversion (BGC). In many taxa (including yeast and mammals), the repair of DNA mismatches is biased toward GC, which probably corresponds to an evolutionary adaptation to a universal mutational bias towards AT. In recombining genomes, this bias in mismatch repair will lead to gene conversion biases. Together with [47•], this paper highlights the importance of taking into account BGC in models of population genetics.
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    • Does recombination improve selection on codon usage? Lessons from nematode and fly complete genomes
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    • Duret, L.1    Mouchiroud, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.