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Volumn 300, Issue , 2015, Pages 593-608

Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats

Author keywords

Absence epilepsy; Guanosine; Inosine; Uridine; WAG Rij rats

Indexed keywords

BICUCULLINE; DIZOCILPINE; GUANOSINE; INOSINE; MUSCIMOL; THEOPHYLLINE; URIDINE; 4 AMINOBUTYRIC ACID A RECEPTOR; ADENOSINE RECEPTOR; ANTICONVULSIVE AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 84931266823     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.05.054     Document Type: Article
Times cited : (31)

References (77)
  • 1
    • 15344348834 scopus 로고    scopus 로고
    • Theophylline, a methylxanthine derivative, suppresses absence epileptic seizures in WAG/Rij rats
    • Ates N., Sahin D., Ilbay G. Theophylline, a methylxanthine derivative, suppresses absence epileptic seizures in WAG/Rij rats. Epilepsy Behav 2004, 5(5):645-648.
    • (2004) Epilepsy Behav , vol.5 , Issue.5 , pp. 645-648
    • Ates, N.1    Sahin, D.2    Ilbay, G.3
  • 2
    • 79954545140 scopus 로고    scopus 로고
    • Modulators of nucleoside metabolism in the therapy of brain diseases
    • Boison D. Modulators of nucleoside metabolism in the therapy of brain diseases. Curr Top Med Chem 2011, 11(8):1068-1086.
    • (2011) Curr Top Med Chem , vol.11 , Issue.8 , pp. 1068-1086
    • Boison, D.1
  • 3
    • 33645862308 scopus 로고    scopus 로고
    • P2 receptors activated by uracil nucleotides-an update
    • Brunschweiger A., Muller C.E. P2 receptors activated by uracil nucleotides-an update. Curr Med Chem 2006, 13(3):289-312.
    • (2006) Curr Med Chem , vol.13 , Issue.3 , pp. 289-312
    • Brunschweiger, A.1    Muller, C.E.2
  • 5
    • 33747886010 scopus 로고    scopus 로고
    • Uridine and cytidine in the brain: their transport and utilization
    • Cansev M. Uridine and cytidine in the brain: their transport and utilization. Brain Res Rev 2006, 52(2):389-397.
    • (2006) Brain Res Rev , vol.52 , Issue.2 , pp. 389-397
    • Cansev, M.1
  • 6
    • 0034142055 scopus 로고    scopus 로고
    • Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia
    • Ciccarelli R., Di Iorio P., D'Alimonte I., Giuliani P., Florio T., Caciagli F., Middlemiss P.J., Rathbone M.P. Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia. Glia 2000, 29(3):202-211.
    • (2000) Glia , vol.29 , Issue.3 , pp. 202-211
    • Ciccarelli, R.1    Di Iorio, P.2    D'Alimonte, I.3    Giuliani, P.4    Florio, T.5    Caciagli, F.6    Middlemiss, P.J.7    Rathbone, M.P.8
  • 7
    • 0345256499 scopus 로고    scopus 로고
    • Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats
    • Coenen A.M., Van Luijtelaar E.L. Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats. Behav Genet 2003, 33(6):635-655.
    • (2003) Behav Genet , vol.33 , Issue.6 , pp. 635-655
    • Coenen, A.M.1    Van Luijtelaar, E.L.2
  • 9
    • 0029069095 scopus 로고
    • Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats
    • Coenen A.M., Blezer E.H., Van Luijtelaar E.L. Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats. Epilepsy Res 1995, 21(2):89-94.
    • (1995) Epilepsy Res , vol.21 , Issue.2 , pp. 89-94
    • Coenen, A.M.1    Blezer, E.H.2    Van Luijtelaar, E.L.3
  • 11
    • 84886536095 scopus 로고    scopus 로고
    • GABA-A receptor function in typical absence seizures.
    • Jasper's Basic Mechanisms of the Epilepsies [Internet] (Noebels JL, Avoli M, Rogawski MA, et al., eds), 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); .
    • Crunelli V, Leresche N, Cope DW (2012) GABA-A receptor function in typical absence seizures. In: Jasper's Basic Mechanisms of the Epilepsies [Internet] (Noebels JL, Avoli M, Rogawski MA, et al., eds), 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); . http://www.ncbi.nlm.nih.gov/books/NBK98213/.
    • (2012)
    • Crunelli, V.1    Leresche, N.2    Cope, D.W.3
  • 13
    • 3242669826 scopus 로고    scopus 로고
    • Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine
    • De Oliveira D.L., Horn J.F., Rodrigues J.M., Frizzo M.E., Moriguchi E., Souza D.O., Wofchuk S. Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. Brain Res 2004, 1018(1):48-54.
    • (2004) Brain Res , vol.1018 , Issue.1 , pp. 48-54
    • De Oliveira, D.L.1    Horn, J.F.2    Rodrigues, J.M.3    Frizzo, M.E.4    Moriguchi, E.5    Souza, D.O.6    Wofchuk, S.7
  • 14
    • 84882841597 scopus 로고    scopus 로고
    • Genetic models of absence epilepsy in the rat.
    • Models of seizures and epilepsy, Chapter 18 (Pitkänen A, Schwartzkroin PA, Moshé SL, eds), Academic Press.
    • Depaulis A, Van Luijtelaar G (2005) Genetic models of absence epilepsy in the rat. In: Models of seizures and epilepsy, Chapter 18 (Pitkänen A, Schwartzkroin PA, Moshé SL, eds), pp 233-248. Academic Press.
    • (2005) , pp. 233-248
    • Depaulis, A.1    Van Luijtelaar, G.2
  • 16
    • 0033615242 scopus 로고    scopus 로고
    • Uridine is released by depolarization and inhibits unit activity in the rat hippocampus
    • Dobolyi Á., Szikra T., Kékesi A.K., Kovács Z., Juhász G. Uridine is released by depolarization and inhibits unit activity in the rat hippocampus. Neuroreport 1999, 10(14):3049-3053.
    • (1999) Neuroreport , vol.10 , Issue.14 , pp. 3049-3053
    • Dobolyi, Á.1    Szikra, T.2    Kékesi, A.K.3    Kovács, Z.4    Juhász, G.5
  • 17
    • 0026041889 scopus 로고
    • Spike-wave discharges and sleep-wake states in rats with absence epilepsy
    • Drinkenburg W.H., Coenen A.M., Vossen J.M., Van Luijtelaar E.L. Spike-wave discharges and sleep-wake states in rats with absence epilepsy. Epilepsy Res 1991, 9(3):218-224.
    • (1991) Epilepsy Res , vol.9 , Issue.3 , pp. 218-224
    • Drinkenburg, W.H.1    Coenen, A.M.2    Vossen, J.M.3    Van Luijtelaar, E.L.4
  • 18
    • 0035372334 scopus 로고    scopus 로고
    • 8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance
    • Filakovszky J., Kantor S., Halasz P., Bagdy G. 8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance. Neurochem Int 2001, 38(7):551-556.
    • (2001) Neurochem Int , vol.38 , Issue.7 , pp. 551-556
    • Filakovszky, J.1    Kantor, S.2    Halasz, P.3    Bagdy, G.4
  • 19
    • 0018654388 scopus 로고
    • Release of 3H-nucleosides from 3H-adenine labelled hypothalamic synaptosomes
    • Fredholm B.B., Vernet L. Release of 3H-nucleosides from 3H-adenine labelled hypothalamic synaptosomes. Acta Physiol Scand 1979, 106(2):97-107.
    • (1979) Acta Physiol Scand , vol.106 , Issue.2 , pp. 97-107
    • Fredholm, B.B.1    Vernet, L.2
  • 20
    • 0037449176 scopus 로고    scopus 로고
    • Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake
    • Frizzo M.E., Antunes Soares F.A., Dall'Onder L.P., Lara D.R., Swanson R.A., Souza D.O. Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake. Brain Res 2003, 972(1-2):84-89.
    • (2003) Brain Res , vol.972 , Issue.1-2 , pp. 84-89
    • Frizzo, M.E.1    Antunes Soares, F.A.2    Dall'Onder, L.P.3    Lara, D.R.4    Swanson, R.A.5    Souza, D.O.6
  • 21
    • 80053362998 scopus 로고    scopus 로고
    • Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors
    • Ganzella M., Faraco R.B., Almeida R.F., Fernandes V.F., Souza D.O. Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors. Pharmacol Biochem Behav 2011, 100(2):271-274.
    • (2011) Pharmacol Biochem Behav , vol.100 , Issue.2 , pp. 271-274
    • Ganzella, M.1    Faraco, R.B.2    Almeida, R.F.3    Fernandes, V.F.4    Souza, D.O.5
  • 23
    • 0022339360 scopus 로고
    • Interaction between uridine and GABA-mediated inhibitory transmission: studies in vivo and in vitro
    • Guarneri P., Guarneri R., La Bella V., Piccoli F. Interaction between uridine and GABA-mediated inhibitory transmission: studies in vivo and in vitro. Epilepsia 1985, 26(6):666-671.
    • (1985) Epilepsia , vol.26 , Issue.6 , pp. 666-671
    • Guarneri, P.1    Guarneri, R.2    La Bella, V.3    Piccoli, F.4
  • 24
    • 1342264245 scopus 로고    scopus 로고
    • Immunomodulatory and neuroprotective effects of inosine
    • Haskó G., Sitkovsky M.V., Cs Szabó. Immunomodulatory and neuroprotective effects of inosine. Trends Pharmacol Sci 2004, 25(3):152-157.
    • (2004) Trends Pharmacol Sci , vol.25 , Issue.3 , pp. 152-157
    • Haskó, G.1    Sitkovsky, M.V.2    Cs, Szabó.3
  • 25
    • 0022358687 scopus 로고
    • Sleep-promoting effects of intraperitoneally administered uridine in unrestrained rats
    • Honda K., Okano Y., Komoda Y., Inoué S. Sleep-promoting effects of intraperitoneally administered uridine in unrestrained rats. Neurosci Lett 1985, 62(1):137-141.
    • (1985) Neurosci Lett , vol.62 , Issue.1 , pp. 137-141
    • Honda, K.1    Okano, Y.2    Komoda, Y.3    Inoué, S.4
  • 26
    • 0034903940 scopus 로고    scopus 로고
    • Effects of adenosine administration on spike-wave discharge frequency in genetically epileptic rats
    • Ilbay G., Sahin D., Karson A., Ates N. Effects of adenosine administration on spike-wave discharge frequency in genetically epileptic rats. Clin Exp Pharmacol Physiol 2001, 28(8):643-646.
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , Issue.8 , pp. 643-646
    • Ilbay, G.1    Sahin, D.2    Karson, A.3    Ates, N.4
  • 27
    • 84859340952 scopus 로고    scopus 로고
    • Origin, utilization, and recycling of nucleosides in the central nervous system
    • Ipata P.L. Origin, utilization, and recycling of nucleosides in the central nervous system. Adv Physiol Educ 2011, 35(4):342-346.
    • (2011) Adv Physiol Educ , vol.35 , Issue.4 , pp. 342-346
    • Ipata, P.L.1
  • 28
    • 84931273081 scopus 로고    scopus 로고
    • The regulation of brain nucleoside utilization
    • Ipata P.L., Balestri F. The regulation of brain nucleoside utilization. Curr Metabolomics 2014, 2(2):144-154.
    • (2014) Curr Metabolomics , vol.2 , Issue.2 , pp. 144-154
    • Ipata, P.L.1    Balestri, F.2
  • 29
    • 0029058432 scopus 로고
    • Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography
    • Johansson B., Fredholm B.B. Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography. Neuropharmacology 1995, 34(4):393-403.
    • (1995) Neuropharmacology , vol.34 , Issue.4 , pp. 393-403
    • Johansson, B.1    Fredholm, B.B.2
  • 30
    • 0035341425 scopus 로고    scopus 로고
    • Uridine receptor: discovery and its involvement in sleep mechanism
    • Kimura T., Ho I.K., Yamamoto I. Uridine receptor: discovery and its involvement in sleep mechanism. Sleep 2001, 24(3):251-260.
    • (2001) Sleep , vol.24 , Issue.3 , pp. 251-260
    • Kimura, T.1    Ho, I.K.2    Yamamoto, I.3
  • 31
    • 0034955175 scopus 로고    scopus 로고
    • Possible existence of a novel receptor for uridine analogues in the central nervous system using two isomers, N3-(S)-(+)- and N3-(R)-(-)-alpha-hydroxy-beta-phenethyluridines
    • Kimura T., Miki M., Ikeda M., Yonemoto S., Watanabe K., Kondo S., Ho I.K., Yamamoto I. Possible existence of a novel receptor for uridine analogues in the central nervous system using two isomers, N3-(S)-(+)- and N3-(R)-(-)-alpha-hydroxy-beta-phenethyluridines. Biol Pharm Bull 2001, 24(6):729-731.
    • (2001) Biol Pharm Bull , vol.24 , Issue.6 , pp. 729-731
    • Kimura, T.1    Miki, M.2    Ikeda, M.3    Yonemoto, S.4    Watanabe, K.5    Kondo, S.6    Ho, I.K.7    Yamamoto, I.8
  • 32
    • 0030248976 scopus 로고    scopus 로고
    • Thalamic NMDA transmission in a genetic model of absence epilepsy in rats
    • Koerner C., Danober L., Boehrer A., Marescaux C., Vergnes M. Thalamic NMDA transmission in a genetic model of absence epilepsy in rats. Epilepsy Res 1996, 25(1):11-19.
    • (1996) Epilepsy Res , vol.25 , Issue.1 , pp. 11-19
    • Koerner, C.1    Danober, L.2    Boehrer, A.3    Marescaux, C.4    Vergnes, M.5
  • 33
    • 84879399892 scopus 로고    scopus 로고
    • Anatomical distribution of nucleoside system in the human brain and implications for therapy
    • Business Media, New York, Springer Science, S.A. Masino, D. Boison (Eds.)
    • Kovács Z., Dobolyi A. Anatomical distribution of nucleoside system in the human brain and implications for therapy. Adenosine: a key link between metabolism and brain activity 2013, 621-656. Business Media, New York, Springer Science. S.A. Masino, D. Boison (Eds.).
    • (2013) Adenosine: a key link between metabolism and brain activity , pp. 621-656
    • Kovács, Z.1    Dobolyi, A.2
  • 35
    • 76849117683 scopus 로고    scopus 로고
    • Nucleoside map of the human central nervous system
    • Kovács Z., Dobolyi A., Juhász G., Kékesi K.A. Nucleoside map of the human central nervous system. Neurochem Res 2010, 35(3):452-464.
    • (2010) Neurochem Res , vol.35 , Issue.3 , pp. 452-464
    • Kovács, Z.1    Dobolyi, A.2    Juhász, G.3    Kékesi, K.A.4
  • 36
    • 79954489669 scopus 로고    scopus 로고
    • Area, age and gender dependence of the nucleoside system in the brain: a review of current literature
    • Kovács Z., Juhász G., Palkovits M., Dobolyi A., Kékesi K.A. Area, age and gender dependence of the nucleoside system in the brain: a review of current literature. Curr Top Med Chem 2011, 11(8):1012-1033.
    • (2011) Curr Top Med Chem , vol.11 , Issue.8 , pp. 1012-1033
    • Kovács, Z.1    Juhász, G.2    Palkovits, M.3    Dobolyi, A.4    Kékesi, K.A.5
  • 37
    • 84887891549 scopus 로고    scopus 로고
    • 5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications
    • Kovács Z., Dobolyi Á., Kékesi A., Juhász G. 5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications. Curr Med Chem 2013, 20(34):4217-4240.
    • (2013) Curr Med Chem , vol.20 , Issue.34 , pp. 4217-4240
    • Kovács, Z.1    Dobolyi, Á.2    Kékesi, A.3    Juhász, G.4
  • 38
    • 84879384916 scopus 로고    scopus 로고
    • Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats
    • Kovács Z., Slézia A., Bali Z.K., Kovács P., Dobolyi A., Szikra T., Hernádi I., Juhász G. Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats. Brain Res Bull 2013, 97:16-23.
    • (2013) Brain Res Bull , vol.97 , pp. 16-23
    • Kovács, Z.1    Slézia, A.2    Bali, Z.K.3    Kovács, P.4    Dobolyi, A.5    Szikra, T.6    Hernádi, I.7    Juhász, G.8
  • 40
    • 84921835796 scopus 로고    scopus 로고
    • Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: a summary of current literature
    • Kovács Z., Kékesi K.A., Juhász G., Barna J., Héja L., Lakatos R., Dobolyi A. Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: a summary of current literature. Mini Rev Med Chem 2015, 14(13):1033-1042.
    • (2015) Mini Rev Med Chem , vol.14 , Issue.13 , pp. 1033-1042
    • Kovács, Z.1    Kékesi, K.A.2    Juhász, G.3    Barna, J.4    Héja, L.5    Lakatos, R.6    Dobolyi, A.7
  • 41
    • 0018253171 scopus 로고
    • Effects of natural pyrimidines and of certain related compounds on the spontaneous activity of the mouse
    • Krooth R.S., Hsiao W.L., Lam G.F. Effects of natural pyrimidines and of certain related compounds on the spontaneous activity of the mouse. J Pharmacol Exp Ther 1978, 207(2):504-514.
    • (1978) J Pharmacol Exp Ther , vol.207 , Issue.2 , pp. 504-514
    • Krooth, R.S.1    Hsiao, W.L.2    Lam, G.F.3
  • 42
    • 0035823332 scopus 로고    scopus 로고
    • Effect of orally administered guanosine on seizures and death induced by glutamatergic agents
    • Lara D.R., Schmidt A.P., Frizzo M.E., Burgos J.S., Ramírez G., Souza D.O. Effect of orally administered guanosine on seizures and death induced by glutamatergic agents. Brain Res 2001, 912(2):176-180.
    • (2001) Brain Res , vol.912 , Issue.2 , pp. 176-180
    • Lara, D.R.1    Schmidt, A.P.2    Frizzo, M.E.3    Burgos, J.S.4    Ramírez, G.5    Souza, D.O.6
  • 43
    • 0021821940 scopus 로고
    • Effect of inosine on seizures induced with pentylenetetrazole, bicuculline, or picrotoxin
    • Lewin E., Bleck V. Effect of inosine on seizures induced with pentylenetetrazole, bicuculline, or picrotoxin. Epilepsia 1985, 26(3):258-261.
    • (1985) Epilepsia , vol.26 , Issue.3 , pp. 258-261
    • Lewin, E.1    Bleck, V.2
  • 44
    • 0026610852 scopus 로고
    • Involvement of intrathalamic GABAB neurotransmission in the control of absence seizures in the rat
    • Liu Z., Vergnes M., Depaulis A., Marescaux C. Involvement of intrathalamic GABAB neurotransmission in the control of absence seizures in the rat. Neuroscience 1992, 48(1):87-93.
    • (1992) Neuroscience , vol.48 , Issue.1 , pp. 87-93
    • Liu, Z.1    Vergnes, M.2    Depaulis, A.3    Marescaux, C.4
  • 45
    • 80955178319 scopus 로고    scopus 로고
    • Electrical stimulation of the epileptic focus in absence epileptic WAG/Rij rats: assessment of local and network excitability
    • Lüttjohann A., Zhang S., de Peijper R., van Luijtelaar G. Electrical stimulation of the epileptic focus in absence epileptic WAG/Rij rats: assessment of local and network excitability. Neuroscience 2011, 188:125-134.
    • (2011) Neuroscience , vol.188 , pp. 125-134
    • Lüttjohann, A.1    Zhang, S.2    de Peijper, R.3    van Luijtelaar, G.4
  • 46
    • 0019515832 scopus 로고
    • The benzodiazepines and inosine antagonize caffeine-induced seizures
    • Marangos P.J., Martino A.M., Paul S.M., Skolnick P. The benzodiazepines and inosine antagonize caffeine-induced seizures. Psychopharmacology 1981, 72(3):269-273.
    • (1981) Psychopharmacology , vol.72 , Issue.3 , pp. 269-273
    • Marangos, P.J.1    Martino, A.M.2    Paul, S.M.3    Skolnick, P.4
  • 47
    • 84864083358 scopus 로고    scopus 로고
    • Purines and neuronal excitability: links to the ketogenic diet
    • Masino S.A., Kawamura M., Ruskin D.N., Geiger J.D., Boison D. Purines and neuronal excitability: links to the ketogenic diet. Epilepsy Res 2012, 100(3):229-238.
    • (2012) Epilepsy Res , vol.100 , Issue.3 , pp. 229-238
    • Masino, S.A.1    Kawamura, M.2    Ruskin, D.N.3    Geiger, J.D.4    Boison, D.5
  • 48
    • 0032575715 scopus 로고    scopus 로고
    • Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
    • Moghaddam B., Adams B.W. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 1998, 281(5381):1349-1352.
    • (1998) Science , vol.281 , Issue.5381 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.W.2
  • 49
    • 0029927717 scopus 로고    scopus 로고
    • Identification of an extracellular motif involved in the binding of guanine nucleotides by a glutamate receptor
    • Paas Y., Devillers-Thiéry A., Changeux J.P., Medevielle F., Teichberg V.I. Identification of an extracellular motif involved in the binding of guanine nucleotides by a glutamate receptor. EMBO J 1996, 15(7):1548-1556.
    • (1996) EMBO J , vol.15 , Issue.7 , pp. 1548-1556
    • Paas, Y.1    Devillers-Thiéry, A.2    Changeux, J.P.3    Medevielle, F.4    Teichberg, V.I.5
  • 50
    • 0003698235 scopus 로고    scopus 로고
    • Academic Press, Orlando, G. Paxinos, C. Watson (Eds.)
    • The rat brain stereotaxic coordinates 1999, Academic Press, Orlando. G. Paxinos, C. Watson (Eds.).
    • (1999) The rat brain stereotaxic coordinates
  • 51
    • 0024474236 scopus 로고
    • Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/RIJ inbred strain of rats
    • Peeters B.W., Van Rijn C.M., Vossen J.M., Coenen A.M. Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/RIJ inbred strain of rats. Life Sci 1989, 45(13):1171-1176.
    • (1989) Life Sci , vol.45 , Issue.13 , pp. 1171-1176
    • Peeters, B.W.1    Van Rijn, C.M.2    Vossen, J.M.3    Coenen, A.M.4
  • 52
    • 50849103629 scopus 로고    scopus 로고
    • Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy
    • Pisu M.G., Mostallino M.C., Dore R., Mura M.L., Maciocco E., Russo E., De Sarro G., Serra M. Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy. J Neurochem 2008, 106(6):2502-2514.
    • (2008) J Neurochem , vol.106 , Issue.6 , pp. 2502-2514
    • Pisu, M.G.1    Mostallino, M.C.2    Dore, R.3    Mura, M.L.4    Maciocco, E.5    Russo, E.6    De Sarro, G.7    Serra, M.8
  • 53
    • 21744445919 scopus 로고    scopus 로고
    • Uridine enhances neurite outgrowth in nerve growth factor-differentiated pheochromocytoma cells
    • Pooler A.M., Guez D.H., Benedictus R., Wurtman R.J. Uridine enhances neurite outgrowth in nerve growth factor-differentiated pheochromocytoma cells. Neuroscience 2005, 134(1):207-214.
    • (2005) Neuroscience , vol.134 , Issue.1 , pp. 207-214
    • Pooler, A.M.1    Guez, D.H.2    Benedictus, R.3    Wurtman, R.J.4
  • 54
    • 0037154735 scopus 로고    scopus 로고
    • Guanine based purines inhibit [(3)H]glutamate and [(3)H]AMPA binding at postsynaptic densities from cerebral cortex of rats
    • Porciúncula L.O., Vinadé L., Wofchuk S., Souza D.O. Guanine based purines inhibit [(3)H]glutamate and [(3)H]AMPA binding at postsynaptic densities from cerebral cortex of rats. Brain Res 2002, 928(1-2):106-112.
    • (2002) Brain Res , vol.928 , Issue.1-2 , pp. 106-112
    • Porciúncula, L.O.1    Vinadé, L.2    Wofchuk, S.3    Souza, D.O.4
  • 55
    • 0025996511 scopus 로고
    • Extracellular guanosine increases astrocyte cAMP: inhibition by adenosine A2 antagonists
    • Rathbone M.P., Middlemiss P.J., DeLuca B., Jovetich M. Extracellular guanosine increases astrocyte cAMP: inhibition by adenosine A2 antagonists. Neuroreport 1991, 2(11):661-664.
    • (1991) Neuroreport , vol.2 , Issue.11 , pp. 661-664
    • Rathbone, M.P.1    Middlemiss, P.J.2    DeLuca, B.3    Jovetich, M.4
  • 56
    • 0015797746 scopus 로고
    • Anticonvulsant effects of uridine: comparative analysis of metrazol and penicillin induced foci
    • Roberts C.A. Anticonvulsant effects of uridine: comparative analysis of metrazol and penicillin induced foci. Brain Res 1973, 55(2):291-308.
    • (1973) Brain Res , vol.55 , Issue.2 , pp. 291-308
    • Roberts, C.A.1
  • 57
    • 36049020643 scopus 로고    scopus 로고
    • Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus
    • Sakamoto T., Cansev M., Wurtman R.J. Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res 2007, 1182:50-59.
    • (2007) Brain Res , vol.1182 , pp. 50-59
    • Sakamoto, T.1    Cansev, M.2    Wurtman, R.J.3
  • 59
    • 13844294355 scopus 로고    scopus 로고
    • Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice
    • Schmidt A.P., Avila T.T., Souza D.O. Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice. Neurochem Res 2005, 30(1):69-73.
    • (2005) Neurochem Res , vol.30 , Issue.1 , pp. 69-73
    • Schmidt, A.P.1    Avila, T.T.2    Souza, D.O.3
  • 60
    • 36148999810 scopus 로고    scopus 로고
    • Proposal of a guanine-based purinergic system in the mammalian central nervous system
    • Schmidt A.P., Lara D.R., Souza D.O. Proposal of a guanine-based purinergic system in the mammalian central nervous system. Pharmacol Ther 2007, 116(3):401-416.
    • (2007) Pharmacol Ther , vol.116 , Issue.3 , pp. 401-416
    • Schmidt, A.P.1    Lara, D.R.2    Souza, D.O.3
  • 62
    • 0035254572 scopus 로고    scopus 로고
    • Tonic and burst firing: dual modes of thalamocortical relay
    • Sherman S.M. Tonic and burst firing: dual modes of thalamocortical relay. Trends Neurosci 2001, 24(2):122-126.
    • (2001) Trends Neurosci , vol.24 , Issue.2 , pp. 122-126
    • Sherman, S.M.1
  • 63
    • 0348091162 scopus 로고
    • Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures
    • Skolnick P., Syapin P.J., Paugh B.A., Moncada V., Marangos P.J., Paul S.M. Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures. Proc Natl Acad Sci U S A 1979, 76(3):1515-1518.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , Issue.3 , pp. 1515-1518
    • Skolnick, P.1    Syapin, P.J.2    Paugh, B.A.3    Moncada, V.4    Marangos, P.J.5    Paul, S.M.6
  • 65
    • 0028896579 scopus 로고
    • Basic mechanisms of generalized absence seizures
    • Snead O.C. Basic mechanisms of generalized absence seizures. Ann Neurol 1995, 37(2):146-157.
    • (1995) Ann Neurol , vol.37 , Issue.2 , pp. 146-157
    • Snead, O.C.1
  • 67
    • 36949014321 scopus 로고    scopus 로고
    • Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines
    • Tavares R.G., Schmidt A.P., Tasca C.I., Souza D.O. Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines. Neurochem Res 2008, 33(1):97-102.
    • (2008) Neurochem Res , vol.33 , Issue.1 , pp. 97-102
    • Tavares, R.G.1    Schmidt, A.P.2    Tasca, C.I.3    Souza, D.O.4
  • 70
    • 79958025263 scopus 로고    scopus 로고
    • On the origin and suddenness of absences in genetic absence models
    • Van Luijtelaar G., Sitnikova E., Littjohann A. On the origin and suddenness of absences in genetic absence models. Clin EEG Neurosci 2011, 42(2):83-97.
    • (2011) Clin EEG Neurosci , vol.42 , Issue.2 , pp. 83-97
    • Van Luijtelaar, G.1    Sitnikova, E.2    Littjohann, A.3
  • 73
    • 84899635066 scopus 로고    scopus 로고
    • A nutrient combination that can affect synapse formation
    • Wurtman R.J. A nutrient combination that can affect synapse formation. Nutrients 2014, 6(4):1701-1710.
    • (2014) Nutrients , vol.6 , Issue.4 , pp. 1701-1710
    • Wurtman, R.J.1
  • 74
    • 63249114054 scopus 로고    scopus 로고
    • Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
    • Wurtman R.J., Cansev M., Ulus I.H. Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides. J Nutr Health Aging 2009, 13(3):189-197.
    • (2009) J Nutr Health Aging , vol.13 , Issue.3 , pp. 189-197
    • Wurtman, R.J.1    Cansev, M.2    Ulus, I.H.3
  • 75
    • 33745376179 scopus 로고    scopus 로고
    • Effects of uridine in models of epileptogenesis and seizures
    • Zhao Q., Marolewski A., Rusche J.R., Holmes G.L. Effects of uridine in models of epileptogenesis and seizures. Epilepsy Res 2006, 70(1):73-82.
    • (2006) Epilepsy Res , vol.70 , Issue.1 , pp. 73-82
    • Zhao, Q.1    Marolewski, A.2    Rusche, J.R.3    Holmes, G.L.4
  • 77
    • 0030221465 scopus 로고    scopus 로고
    • Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system
    • Zimmermann H. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog Neurobiol 1996, 49(6):589-618.
    • (1996) Prog Neurobiol , vol.49 , Issue.6 , pp. 589-618
    • Zimmermann, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.