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Volumn 6, Issue 15, 2015, Pages 13416-13433

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment

Author keywords

ANGPTL4; Linoleic acid; Ovarian carcinoma; PPAR ; Tumor associated macrophages

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE 4; CD300A ANTIGEN; FAT DROPLET; FATTY ACID; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LYMPHOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 8; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; POLYUNSATURATED FATTY ACID; TRANSCRIPTOME; UNCLASSIFIED DRUG; LIGAND;

EID: 84931044554     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3826     Document Type: Article
Times cited : (84)

References (62)
  • 1
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J and Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006; 124:263-266.
    • (2006) Cell. , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 2
    • 63149160727 scopus 로고    scopus 로고
    • Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB
    • Hagemann T, Biswas SK, Lawrence T, Sica A and Lewis CE. Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB. Blood. 2009; 113:3139-3146.
    • (2009) Blood. , vol.113 , pp. 3139-3146
    • Hagemann, T.1    Biswas, S.K.2    Lawrence, T.3    Sica, A.4    Lewis, C.E.5
  • 3
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 2004; 4:71-78.
    • (2004) Nat Rev Cancer. , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 4
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • Sica A and Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012; 122:787-795.
    • (2012) J Clin Invest. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 7
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ and Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010; 141:39-51.
    • (2010) Cell. , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 9
    • 27944505915 scopus 로고    scopus 로고
    • PPARs in diseases: control mechanisms of inflammation
    • Kostadinova R, Wahli W and Michalik L. PPARs in diseases: control mechanisms of inflammation. Curr Med Chem. 2005; 12:2995-3009.
    • (2005) Curr Med Chem. , vol.12 , pp. 2995-3009
    • Kostadinova, R.1    Wahli, W.2    Michalik, L.3
  • 10
    • 84863104065 scopus 로고    scopus 로고
    • PPARs at the crossroads of lipid signaling and inflammation
    • Wahli W and Michalik L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab. 2012; 23:351-363.
    • (2012) Trends Endocrinol Metab. , vol.23 , pp. 351-363
    • Wahli, W.1    Michalik, L.2
  • 11
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
    • Peters JM, Lee SS, Li W, Ward JM, Gavrilova O, Everett C, Reitman ML, Hudson LD and Gonzalez FJ. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol. 2000; 20:5119-5128.
    • (2000) Mol Cell Biol. , vol.20 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.2    Li, W.3    Ward, J.M.4    Gavrilova, O.5    Everett, C.6    Reitman, M.L.7    Hudson, L.D.8    Gonzalez, F.J.9
  • 13
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B and Lee CH. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008; 7:485-495.
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6    Lee, C.H.7
  • 15
    • 84857641358 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
    • Peters JM, Shah YM and Gonzalez FJ. The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nat Rev Cancer. 2012; 12:181-195.
    • (2012) Nat Rev Cancer. , vol.12 , pp. 181-195
    • Peters, J.M.1    Shah, Y.M.2    Gonzalez, F.J.3
  • 22
    • 44949181877 scopus 로고    scopus 로고
    • SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta
    • Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T and Nagai R. SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med. 2008; 14:656-666.
    • (2008) Nat Med. , vol.14 , pp. 656-666
    • Oishi, Y.1    Manabe, I.2    Tobe, K.3    Ohsugi, M.4    Kubota, T.5    Fujiu, K.6    Maemura, K.7    Kubota, N.8    Kadowaki, T.9    Nagai, R.10
  • 26
    • 33744519163 scopus 로고    scopus 로고
    • PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes
    • Ding G, Cheng L, Qin Q, Frontin S and Yang Q. PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes. J Mol Cell Cardiol. 2006; 40:821-828.
    • (2006) J Mol Cell Cardiol. , vol.40 , pp. 821-828
    • Ding, G.1    Cheng, L.2    Qin, Q.3    Frontin, S.4    Yang, Q.5
  • 29
    • 0028116948 scopus 로고
    • Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors
    • Yamashiro S, Takeya M, Nishi T, Kuratsu J, Yoshimura T, Ushio Y and Takahashi K. Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors. Am J Pathol. 1994; 145:856-867.
    • (1994) Am J Pathol. , vol.145 , pp. 856-867
    • Yamashiro, S.1    Takeya, M.2    Nishi, T.3    Kuratsu, J.4    Yoshimura, T.5    Ushio, Y.6    Takahashi, K.7
  • 31
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A and Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004; 104:2224-2234.
    • (2004) Blood. , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 32
    • 84891138385 scopus 로고    scopus 로고
    • Getting to Know Ovarian Cancer Ascites: Opportunities for Targeted Therapy-Based Translational Research
    • Ahmed N and Stenvers KL. Getting to Know Ovarian Cancer Ascites: Opportunities for Targeted Therapy-Based Translational Research. Front Oncol. 2013; 3:256.
    • (2013) Front Oncol , vol.3 , pp. 256
    • Ahmed, N.1    Stenvers, K.L.2
  • 34
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Network TCGAR. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474:609-615.
    • (2011) Nature. , vol.474 , pp. 609-615
  • 35
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR and Massague J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008; 133:66-77.
    • (2008) Cell. , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 38
    • 0022553161 scopus 로고
    • Isolation and characterization of a cellular protein-lipid complex from ascites fluid caused by various neoplasms
    • Caselmann WH and Jungst D. Isolation and characterization of a cellular protein-lipid complex from ascites fluid caused by various neoplasms. Cancer Res. 1986; 46:1547-1552.
    • (1986) Cancer Res. , vol.46 , pp. 1547-1552
    • Caselmann, W.H.1    Jungst, D.2
  • 39
    • 0031023905 scopus 로고    scopus 로고
    • Subcutaneous, omentum and tumor fatty acid composition, and serum insulin status in patients with benign or cancerous ovarian or endometrial tumors. Do tumors preferentially utilize polyunsaturated fatty acids?
    • Yam D, Ben-Hur H, Dgani R, Fink A, Shani A and Berry EM. Subcutaneous, omentum and tumor fatty acid composition, and serum insulin status in patients with benign or cancerous ovarian or endometrial tumors. Do tumors preferentially utilize polyunsaturated fatty acids? Cancer Lett. 1997; 111:179-185.
    • (1997) Cancer Lett. , vol.111 , pp. 179-185
    • Yam, D.1    Ben-Hur, H.2    Dgani, R.3    Fink, A.4    Shani, A.5    Berry, E.M.6
  • 40
    • 0031007392 scopus 로고    scopus 로고
    • Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
    • Gansler TS, Hardman W, 3rd, Hunt DA, Schaffel S and Hennigar RA. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol. 1997; 28:686-692.
    • (1997) Hum Pathol. , vol.28 , pp. 686-692
    • Gansler, T.S.1    Hardman 3rd, W.2    Hunt, D.A.3    Schaffel, S.4    Hennigar, R.A.5
  • 41
    • 78149423097 scopus 로고    scopus 로고
    • Association of lipid metabolism with ovarian cancer
    • Tania M, Khan MA and Song Y. Association of lipid metabolism with ovarian cancer. Curr Oncol. 2010; 17:6-11.
    • (2010) Curr Oncol. , vol.17 , pp. 6-11
    • Tania, M.1    Khan, M.A.2    Song, Y.3
  • 43
    • 0032702547 scopus 로고    scopus 로고
    • Changes in plasma free fatty acid concentrations in rheumatoid arthritis patients during fasting and their effects upon T-lymphocyte proliferation
    • Fraser DA, Thoen J, Rustan AC, Forre O and Kjeldsen-Kragh J. Changes in plasma free fatty acid concentrations in rheumatoid arthritis patients during fasting and their effects upon T-lymphocyte proliferation. Rheumatology (Oxford). 1999; 38:948-952.
    • (1999) Rheumatology (Oxford). , vol.38 , pp. 948-952
    • Fraser, D.A.1    Thoen, J.2    Rustan, A.C.3    Forre, O.4    Kjeldsen-Kragh, J.5
  • 44
    • 32644454369 scopus 로고    scopus 로고
    • The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    • Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Muller M and Kersten S. The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem. 2006; 281:934-944.
    • (2006) J Biol Chem. , vol.281 , pp. 934-944
    • Mandard, S.1    Zandbergen, F.2    van Straten, E.3    Wahli, W.4    Kuipers, F.5    Muller, M.6    Kersten, S.7
  • 45
    • 77956547390 scopus 로고    scopus 로고
    • Transcriptional profiling identifies functional interactions of TGFβ and PPARβ/δ signaling: synergistic induction of ANGPTL4 transcription
    • Kaddatz K, Adhikary T, Finkernagel F, Meissner W, Müller-Brüsselbach S and Müller R. Transcriptional profiling identifies functional interactions of TGFβ and PPARβ/δ signaling: synergistic induction of ANGPTL4 transcription. J Biol Chem. 2010; 285:29469-29479.
    • (2010) J Biol Chem. , vol.285 , pp. 29469-29479
    • Kaddatz, K.1    Adhikary, T.2    Finkernagel, F.3    Meissner, W.4    Müller-Brüsselbach, S.5    Müller, R.6
  • 50
    • 0023902548 scopus 로고
    • Enhancement of c-fos expression is associated with activated macrophages
    • Higuchi Y, Setoguchi M, Yoshida S, Akizuki S and Yamamoto S. Enhancement of c-fos expression is associated with activated macrophages. Oncogene. 1988; 2:515-521.
    • (1988) Oncogene. , vol.2 , pp. 515-521
    • Higuchi, Y.1    Setoguchi, M.2    Yoshida, S.3    Akizuki, S.4    Yamamoto, S.5
  • 51
    • 84868584901 scopus 로고    scopus 로고
    • G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly
    • Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ and Treisman R. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci. 2012; 125:5860-5872.
    • (2012) J Cell Sci. , vol.125 , pp. 5860-5872
    • Wiezlak, M.1    Diring, J.2    Abella, J.3    Mouilleron, S.4    Way, M.5    McDonald, N.Q.6    Treisman, R.7
  • 52
    • 84860169530 scopus 로고    scopus 로고
    • MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer
    • Zhang Y, Wang Z, Chen M, Peng L, Wang X, Ma Q, Ma F and Jiang B. MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. Mol Cancer. 2012; 11:23.
    • (2012) Mol Cancer , vol.11 , pp. 23
    • Zhang, Y.1    Wang, Z.2    Chen, M.3    Peng, L.4    Wang, X.5    Ma, Q.6    Ma, F.7    Jiang, B.8
  • 55
    • 80052782624 scopus 로고    scopus 로고
    • Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages
    • Borrell-Pages M, Romero JC, Juan-Babot O and Badimon L. Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages. Eur Heart J. 2011; 32:2841-2850.
    • (2011) Eur Heart J. , vol.32 , pp. 2841-2850
    • Borrell-Pages, M.1    Romero, J.C.2    Juan-Babot, O.3    Badimon, L.4
  • 56
    • 84860389289 scopus 로고    scopus 로고
    • Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
    • Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G and Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011; 25:1716-1733.
    • (2011) Genes Dev. , vol.25 , pp. 1716-1733
    • Grassian, A.R.1    Metallo, C.M.2    Coloff, J.L.3    Stephanopoulos, G.4    Brugge, J.S.5
  • 59
    • 4043070783 scopus 로고    scopus 로고
    • Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain
    • Hayashi S, Lewis P, Pevny L and McMahon AP. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev. 2002; 119 Suppl 1:S97-S101.
    • (2002) Mech Dev. , vol.119 , pp. S97-S101
    • Hayashi, S.1    Lewis, P.2    Pevny, L.3    McMahon, A.P.4
  • 61
    • 2442726683 scopus 로고    scopus 로고
    • Tissue-specific, cell cycleregulated chimeric transcription factors for the targeting of gene expression to tumor cells
    • Jérôme V and Müller R. Tissue-specific, cell cycleregulated chimeric transcription factors for the targeting of gene expression to tumor cells. Hum Gene Ther. 1998; 9:2653-2659.
    • (1998) Hum Gene Ther. , vol.9 , pp. 2653-2659
    • Jérôme, V.1    Müller, R.2
  • 62
    • 84860903681 scopus 로고    scopus 로고
    • Implementing an online tool for genome-wide validation of survivalassociated biomarkers in ovarian-cancer using microarray data from 1287 patients
    • Gyorffy B, Lanczky A and Szallasi Z. Implementing an online tool for genome-wide validation of survivalassociated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 2012; 19:197-208.
    • (2012) Endocr Relat Cancer. , vol.19 , pp. 197-208
    • Gyorffy, B.1    Lanczky, A.2    Szallasi, Z.3


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