Changes in plasma free fatty acid concentrations in rheumatoid arthritis patients during fasting and their effects upon T-lymphocyte proliferation

Rheumatology

Volumn 38, Issue 10, 1999, Pages 948-952

  Fraser, D A ^a,c   Thoen, J ^a   Rustan, A C ^b   Forre O ^a   Kjeldsen Kragh, J ^c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Fasting; Fatty acids; Lymphocyte proliferation; Rheumatoid arthritis

Indexed keywords

FATTY ACID; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; SATURATED FATTY ACID; STEARIC ACID; UNSATURATED FATTY ACID;

ADULT; AGED; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; DIET RESTRICTION; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CELL DIVISION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FASTING; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 0032702547     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/38.10.948     Document Type: Article

References (18)

1. Calder P. Fat chance of immunomodulation. Immunol Today 1998;19:244-7.
2. Meydani S, Lichtenstein A, Cornwall S et al. Immunologic effects of National Cholesterol Education Panel step-2 diets with and without fish-derived fatty acid enrichment. J Clin Invest 1993;92:105-13.
3. Rossetti R, Seiler C, DeLuca P, Laposata M, Zurier R. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. J Leukoc Biol 1997;62:438-43.
4. Calder P, Newsholme E. Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin Sci 1992;82:695-700.
5. Purasiri P, McKechnie A, Heys S, Eremin O. Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. Immunology 1997;92:166-72.
6. Søyland E, Nenseter M, Braathen L, Drevon C. Very long chain n-3 and n-6 polyunsaturated fatty acids inhibit proliferation of human T-lymphocytes in vitro. Eur J Clin Invest 1993;23:112-21.
7. Klein S, Holland OB, Wolfe RR. Importance of blood glucose concentration in regulating lipolysis during fasting in humans. Am J Physiol 1990;258:E32-9.
8. Steinberg H, Tarshoby M, Monestel R et al. Elevated circulating free-fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997;100:1230-9.
9. Kjeldsen-Kragh J, Haugen M, Borchgrevink CF et al. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet 1991;338:899-902.
10. Hafström I, Ringertz B, Gyllenhammer H, Palmblad J, Harms-Ringdahl M. Effects of fasting in disease activity, neutrophil function, fatty acid composition, and leukotriene biosynthesis in patients with rheumatoid arthritis. Arthritis Rheum 1988;31:585-92.
11. Hagenfeldt L. A gas Chromatographic method for the determination of individual free fatty acids in plasma. Clin Chim Acta 1966;13:266-8.
12. Calder P, Bond J, Bevan S, Hunt S, Newsholme E. Effect of fatty acids on the proliferation of concanavalin A-stimulated rat lymph node lymphocytes. Int J Biochem 1991;23:579-88.
13. Klein S, Wolfe R. Carbohydrate restriction regulates the adaptive response to fasting. Am J Physiol 1992;262: E631-6.
14. Imaichi K, Michaels G, Holton S, Kinsell L. Plasma fatty acids during fasting. Am J Clin Nutr 1963;13:226-31.
15. Calder P, Bevan S, Newsholme E. The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid independent mechanism. Immunology 1992;75: 108-15.
16. Newsholme E, Calder P, Yaqoob P. The regulatory, informational, and immunomodulatory roles of fat fuels. Am J Clin Nutr 1993;57(suppl.):738S-51S.
17. McMurchie E. Dietary lipids and the regulation of membrane fluidity and function. In: Aloia RC, ed. Physiological regulation of membrane fluidity. New York: Liss, 1988:189-204.
18. Swank RL, Dugan BB. Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 1990; 336:37-9.