Tissue-specific, cell cycle-regulated chimeric transcription factors for the targeting of gene expression to tumor cells

Human Gene Therapy

Volumn 9, Issue 18, 1998, Pages 2653-2659

  Jérôme, Valérie ^a   Müller, Rolf ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; MONOPHENOL MONOOXYGENASE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CANCER; CELL CYCLE; CELL PROLIFERATION; CELL TYPE; CYTOTOXICITY; DNA BINDING; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; MELANOMA CELL; NONHUMAN; PROMOTER REGION; TRANSGENE;

ANIMALIA;

EID: 2442726683     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.18-2653     Document Type: Article

References (21)

1. AUSUBEL, I., and FREDERICK, M. (1991). Current Protocols in Molecular Biology. (John Wiley & Sons, New York).
2. BEAN M.A., BLOOM, B.R., HERBERMAN, R.B., OLD, L.J., OETTGEN, H.F., KLEIN, G., and TERRY, W.D. (1975). Cell-mediated cytotoxicity for bladder carcinoma: Evaluation of a workshop. Cancer Res. 35, 2902-2913.
3. CHASMAN, D.I., and KORNBERG, R.D. (1990). GAL4 protein: Purification, association with GAL80 protein, and conserved domain structure. Mol. Cell. Biol. 10, 2916-2923.
4. CONNERS, T.A. (1995). The choice of prodrugs for gene directed enzyme prodrug therapy. Gene Ther. 2, 702-709.
5. DACHS, G.U., PATTERSON, A.V., FIRTH, I.F., RATCLIFFE, P.J., TOWNSEND, K.M.S., STRATFORD, I.J., and HARRIS, A.L. (1997). Targeting gene expression to hypoxic tymor cells. Nature Med 3, 5515-5520.
6. HALLAHAN, D.E., MAUCERI, H.J., SEUNG, L.P., DUNPHY, E.J., WAYNE, J.D., HANNA, N.H., TOLEDANO, A., HELLMAN, S., KUFE, D.W., and WEICHSELBAUM, R.R. (1995). Spatial and temporal control of gene therapy using ionizing radiation. Nature Med. 1, 786-791.
7. HWU, P., SCHWARZ, S., CLUSTER, M., SMITH, C.A., MULE, J.J., and ROSENBERG, S.A. (1992). Use of soluble recombinant TNF receptor to improve detection of TNF-secretion in cultures of tumor infiltrating lymphocytes. J. Immunol. Methods 151, 139-147.
8. KALDERON, D., ROBERTS, B.L., RICHARDSON, W.D., and SMITH, A.E. (1984). A short amino acid sequence able to specify nuclear location. Cell 39, 499-509.
9. MOYE-ROWLEY, W.S., HARSHMAN, K.D., and PARKER, C.S. (1989). Yeast YAP1 encodes a novel form of the Jun family of transcriptional activator protiens. Genes Dev. 3, 283-292.
10. MÜLLER, R. (1995). Transcriptional regulation during the mammalian cell cycle. Trends Genet. 11, 173-178.
11. MÜLLER, R., LÜHRMANN, R., and SEDLACEK, H.H. (1996). Nukleinsäurekonstrukte mit Genen kodierend für Transportsignale. Patent Appl., DE 19617851.7.
12. NIKOLOFF, D.M., McGRAW, P., and HENRY, S.A. (1992). The INO2 gene of S. cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid synthesis. Nucleic Acids Res. 20, 3253.
13. RIGG, A., and SIKORA, K. (1997). Genetic prodrug activation therapy. Mol. Med. Today 3, 359-366.
14. SEWING, A., BÜRGER, C., BRÜSSELBACH, S., SCHALK, C., LUCIBELLO, F.C., and MÜLLER, R. (1993). Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J. Cell Sci. 104, 545-555.
15. SHAW, A., AMREIN, K.E., HAMMOND, C., STERN, D.F., SEFTON, B.M., and ROSE, J.K. (1989). The Lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell 59, 627-636.
16. SHIBATA, K., MURAOSA, Y., TOMITA, Y., TAGAMI, H., and SHIBAHARA, S. (1992). Identification of a cis-acting element that enhances the pigment cell-specific expression of the human tyrosinase gene. J. Biol. Chem. 267, 20584-20588.
17. SIKORA, K. (1993). Gene therapy for cancer. Trends Biotech. 11, 197-201.
18. TRIEZENBERG, S.J., KINGSBURY, R.C., and McKNIGHT, S.L. (1988). Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev. 2, 718-729.
19. TURNER, J.M., BRODSKY, M.H., IRVING, B.A., LEVIN, S.D., PERLMUTTER, R.M., and LITTMAN, D.R. (1990). Interaction of the unique N-terminal region of tyrosinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60, 755-765.
20. WEBSTER, N., JIN, J.R., GREEN, S., HOLLIS, M., and CHAMBON, P. (1988). The yeast UASG is a transcriptional enhancer in HeLa cells in the presence of the GAL4 trans-activator. Cell 52, 169-178.
21. ZWICKER, J., LUCIBELLO, F.C., WOLFRAIM, L.A., GROSS, C., TRUSS, M., ENGELAND, K., and MÜLLER, R. (1995). Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J. 14, 4514-4522.