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Bisgrove, B.W.1
Essner, J.J.2
Yost, H.J.3
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46
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1942477305
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The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry
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This study follows on from an earlier, seminal paper demonstrating the requirement for ntl in DFCs for normal left-right specification in zebrafish. In this paper the authors use mutants and targeted morpholino studies to show that spt is also involved in L/R patterning in a multistep process with ntl. Both Ntl and Spt regulate the mesenchyme to epithelial transition of DFCs to KV. Following this, spt and then ntl in temporal sequence are required for the normal morphological formation of KV.
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Amack J.D., and Yost H.J. The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry. Curr Biol 14 (2004) 685-690. This study follows on from an earlier, seminal paper demonstrating the requirement for ntl in DFCs for normal left-right specification in zebrafish. In this paper the authors use mutants and targeted morpholino studies to show that spt is also involved in L/R patterning in a multistep process with ntl. Both Ntl and Spt regulate the mesenchyme to epithelial transition of DFCs to KV. Following this, spt and then ntl in temporal sequence are required for the normal morphological formation of KV.
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(2004)
Curr Biol
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Amack, J.D.1
Yost, H.J.2
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47
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17244366458
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Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut
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Essner J.J., Amack J.D., Nyholm M.K., Harris E.B., and Yost H.J. Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 132 (2005) 1247-1260
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Development
, vol.132
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Essner, J.J.1
Amack, J.D.2
Nyholm, M.K.3
Harris, E.B.4
Yost, H.J.5
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48
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27744436054
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Polaris and polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis
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Bisgrove B.W., Snarr B.S., Emrazian A., and Yost H.J. Polaris and polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev Biol 287 (2005) 274-288
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Bisgrove, B.W.1
Snarr, B.S.2
Emrazian, A.3
Yost, H.J.4
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49
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34548073070
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Nodal activity around Kupffer's vesicle depends on the T-box transcription factors Notail and Spadetail and on Notch signaling
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This study shows that both ntl and tbx16 are required for normal expression of nodal ligand (southpaw) and antagonist (charon; cha) around KV. An upstream genomic region of cha can drive expression of a reporter gene in cells adjacent to KV in a Ntl-dependent fashion. Notch signaling may also be involved in regulating cha expression since treatment at the end of gastrulation with a gamma-secretase inhibitor, DAPT, which inhibits Notch signaling, causes disruption of cha expression around KV.
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Gourronc F., Ahmad N., Nedza N., Eggleston T., and Rebagliati M. Nodal activity around Kupffer's vesicle depends on the T-box transcription factors Notail and Spadetail and on Notch signaling. Dev Dynamics 236 (2007) 2131-2146. This study shows that both ntl and tbx16 are required for normal expression of nodal ligand (southpaw) and antagonist (charon; cha) around KV. An upstream genomic region of cha can drive expression of a reporter gene in cells adjacent to KV in a Ntl-dependent fashion. Notch signaling may also be involved in regulating cha expression since treatment at the end of gastrulation with a gamma-secretase inhibitor, DAPT, which inhibits Notch signaling, causes disruption of cha expression around KV.
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(2007)
Dev Dynamics
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Gourronc, F.1
Ahmad, N.2
Nedza, N.3
Eggleston, T.4
Rebagliati, M.5
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50
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Wnt3a links left-right determination with segmentation and anteroposterior axis elongation
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Nakaya M., Biris K., Tsukiyama T., Jaime S., Rawls J.A., and Yamaguchi T.P. Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 132 (2005) 5425-5436
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Development
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Nakaya, M.1
Biris, K.2
Tsukiyama, T.3
Jaime, S.4
Rawls, J.A.5
Yamaguchi, T.P.6
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51
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0033573035
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T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification
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Yamaguchi T.P., Takada S., Yoshikawa Y., Wu N., and McMahon A.P. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13 (1999) 3185-3190
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Yamaguchi, T.P.1
Takada, S.2
Yoshikawa, Y.3
Wu, N.4
McMahon, A.P.5
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52
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49249132211
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Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling
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This is the first study to show that Tbx6 affects L/R body axis determination in the mouse and identifies two possible mechanisms for this phenotype: Dll1 is down-regulated around the node in mutants and the cilia of the node are defective. A novel method of visualizing the movement and structure of nodal cilia using a tau-GFP transgene dramatically illustrates the defective movement of the nodal cilia in videos.
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Hadjantonakis A.-K., Pisano E., and Papaioannou V.E. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS One 3 (2008) e2511. This is the first study to show that Tbx6 affects L/R body axis determination in the mouse and identifies two possible mechanisms for this phenotype: Dll1 is down-regulated around the node in mutants and the cilia of the node are defective. A novel method of visualizing the movement and structure of nodal cilia using a tau-GFP transgene dramatically illustrates the defective movement of the nodal cilia in videos.
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(2008)
PLoS One
, vol.3
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Hadjantonakis, A.-K.1
Pisano, E.2
Papaioannou, V.E.3
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53
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Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish
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Amack J.D., Wang X., and Yost H.J. Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish. Dev Biol 310 (2007) 196-210
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Amack, J.D.1
Wang, X.2
Yost, H.J.3
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54
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Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1
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Messenger N.J., Kabitschke C., Andrews R., Grimmer D., Nunez Miguel R., Blundell T.L., Smith J.C., and Wardle F.C. Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev Cell 8 (2005) 559-610
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Messenger, N.J.1
Kabitschke, C.2
Andrews, R.3
Grimmer, D.4
Nunez Miguel, R.5
Blundell, T.L.6
Smith, J.C.7
Wardle, F.C.8
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55
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Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF
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Rodaway A., Takeda H., Koshida S., Broadbent J., Brice B., Smith J.C., Patient R., and Holder N. Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF. Development 126 (1999) 3078-3967
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Broadbent, J.4
Brice, B.5
Smith, J.C.6
Patient, R.7
Holder, N.8
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Mapping and expression analysis the mouse ortholog of Xenopus Eomesodermin
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Hancock S.N., Agulnik S.I., Silver L.M., and Papaioannou V.E. Mapping and expression analysis the mouse ortholog of Xenopus Eomesodermin. Mech Dev 81 (1999) 205-208
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Agulnik, S.I.2
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Expression of the T-box gene Eomesodermin during early mouse development
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Ciruna B.G., and Rossant J. Expression of the T-box gene Eomesodermin during early mouse development. Mech Dev 81 (1999) 199-203
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Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation
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Inman K.E., and Downs K.M. Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation. Gene Expr Patterns 6 (2006) 783-793
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Expression pattern of the mouse T gene and its role in mesoderm formation
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Wilkinson D.G., Bhatt S., and Herrmann B.G. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343 (1990) 657-659
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Bhatt, S.2
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Cloning and expression analysis of the mouse T-box gene Tbx18
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Kraus F., Haenig B., and Kispert A. Cloning and expression analysis of the mouse T-box gene Tbx18. Mech Dev 100 (2001) 83-86
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, vol.100
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Haenig, B.2
Kispert, A.3
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