All-trans retinoic acid induces p53-depenent apoptosis in human hepatocytes by activating p14 expression via promoter hypomethylation

Cancer Letters

Volumn 362, Issue 1, 2015, Pages 139-148

  Heo, Shin Hee ^a   Kwak, Juri ^a   Jang, Kyung Lib ^a  

^a Pusan National University   (South Korea)

Author keywords

All trans retinoic acid; Apoptosis; DNA methylation; P14; P53

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; DNA; DNA METHYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BID; PROTEIN MDM2; PROTEIN P14; PROTEIN P53; PUMA PROTEIN; RETINOIC ACID; ANTINEOPLASTIC AGENT; CDK2AP2 PROTEIN, HUMAN; MDM2 PROTEIN, HUMAN; ONCOPROTEIN; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA METHYLATION; DRUG MECHANISM; ENZYME ACTIVATION; GENE; GENE SILENCING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL; MDM2 GENE; P14 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY; UPREGULATION; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; GENETICS; HCT116 CELL LINE; MCF 7 CELL LINE; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA METHYLATION; GENES, TUMOR SUPPRESSOR; HCT116 CELLS; HEP G2 CELLS; HEPATOCYTES; HUMANS; MCF-7 CELLS; ONCOGENE PROTEINS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; TRETINOIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84931034561     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2015.03.036     Document Type: Article

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