A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

Nature Medicine

Volumn 21, Issue 4, 2015, Pages 383-388

  Wang, Peng ^a   Alvarez Perez, Juan Carlos ^a   Felsenfeld, Dan P ^a   Liu, Hongtao ^a   Sivendran, Sharmila ^a   Bender, Aaron ^a   Kumar, Anil ^a   Sanchez, Roberto ^a   Scott, Donald K ^a   Garcia Ocaña, Adolfo ^a   Stewart, Andrew F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; DYRK KINASE; HARMINE; MONOAMINE OXIDASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR NFAT;

ADOLESCENT; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; FEMALE; HCT116 CELL LINE; HEPG2 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; MALE; METABOLISM; MIDDLE AGED; MOUSE; PANCREAS ISLET BETA CELL; RAT; TIME; WISTAR RAT; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANIMALS; CALCINEURIN; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; HARMINE; HCT116 CELLS; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INSULIN-SECRETING CELLS; MALE; MICE; MIDDLE AGED; MONOAMINE OXIDASE INHIBITORS; NFATC TRANSCRIPTION FACTORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RATS; RATS, WISTAR; TIME FACTORS; YOUNG ADULT;

EID: 84931027346     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3820     Document Type: Article

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