Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

Diabetologia

Volumn 57, Issue 5, 2014, Pages 960-969

  Rachdi, Latif ^a   Kariyawasam, Dulanjalee ^d   Guez, Fanny ^a   Aïello, Virginie ^a   Arbonés, Maria L ^c   Janel, Nathalie ^b   Delabar, Jean Maurice ^b   Polak, Michel ^d   Scharfmann, Raphaël ^a  

^a INSTITUT COCHIN   (France)

^b Groupe Hospitalier Pitié Salpêtrière   (France)

^c CSIC   (Spain)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Beta cell; Diabetes; DYRK1A; p27; Proliferation

Indexed keywords

INSULIN; DYRK KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DUAL SPECIFICITY TYROSINE PHOSPHORYLATIONREGULATED KINASE 1A GENE; GENE; GENE CONTROL; GENE DOSAGE; GENE EXPRESSION; GENE FUNCTION; GLUCOSE BLOOD LEVEL; HAPLOINSUFFICIENCY; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; MOUSE; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; HAPLOINSUFFICIENCY; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 84898601003     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3174-3     Document Type: Article

References (43)

1. Ferrannini E (2010) The stunned beta cell: a brief history. Cell Metab 11:349-352
2. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110 (Pubitemid 36042113)
3. Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta cell: the last ten years. Cell 148:1160-1171
4. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC (2008) Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 10(4):32-42
5. Sachdeva MM, Stoffers DA (2009) Minireview. Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol 23:747-758
6. Becker W, Joost HG (1999) Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. Prog Nucleic Acid Res Mol Biol 62:1-17
7. Aranda S, Laguna A, de la Luna S (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J 25:449-462
8. Tejedor FJ, Hammerle B (2011) MNB/DYRK1A as a multiple regulator of neuronal development. FEBS J 278:223-235
9. Fotaki V, Dierssen M, Alcantara S et al (2002) Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Mol Cell Biol 22:6636-6647
10. Delabar JM, Theophile D, Rahmani Z et al (1993) Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur J Hum Genet 1:114-124
11. Oegema R, de Klein A, Verkerk AJ et al (2010) Distinctive phenotypic abnormalities associated with submicroscopic 21q22 deletion including DYRK1A. Mol Syndromol 1:113-120
12. Le Douarin NM (1988) On the origin of pancreatic endocrine cells. Cell 53:169-171
13. Atouf F, Czernichow P, Scharfmann R (1997) Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer. J Biol Chem 272:1929-1934 (Pubitemid 27043287)
14. Rorsman P (1997) The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40:487-495 (Pubitemid 27186783)
15. van Arensbergen J, Garcia-Hurtado J, Moran I et al (2010) Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome Res 20:722-732
16. Rachdi L, Balcazar N, Osorio-Duque F et al (2008) Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci U S A 105:9250-9255
17. Attali M, Stetsyuk V, Basmaciogullari A et al (2007) Control of beta-cell differentiation by the pancreatic mesenchyme. Diabetes 56:1248-1258 (Pubitemid 46715605)
18. Bain J, McLauchlan H, Elliott M, Cohen P (2003) The specificities of protein kinase inhibitors: an update. Biochem J 371:199-204 (Pubitemid 36458094)
19. Bain J, Plater L, Elliott M et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315
20. Rachdi L, Marie JC, Scharfmann R (2003) Role for VPAC2 receptor-mediated signals in pancreas development. Diabetes 52:85-92 (Pubitemid 36042111)
21. Rachdi L, Balcazar N, Elghazi L et al (2006) Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life. Diabetes 55:3520-3528 (Pubitemid 44923613)
22. Guillemain G, Filhoulaud G, Da Silva-Xavier G, Rutter GA, Scharfmann R (2007) Glucose is necessary for embryonic pancreatic endocrine cell differentiation. J Biol Chem 282:15228-15237 (Pubitemid 47093387)
23. Rachdi L, Aiello V, Duvillie B, Scharfmann R (2012) L-leucine alters pancreatic beta-cell differentiation and function via the mTor signaling pathway. Diabetes 61:409-417
24. Waki H, Park KW, Mitro N et al (2007) The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5:357-370 (Pubitemid 46667757)
25. Olbrot M, Rud J, Moss LG, Sharma A (2002) Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A 99:6737-6742 (Pubitemid 34526201)
26. Naya FJ, Huang HP, Qiu Y et al (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11:2323-2334 (Pubitemid 27408530)
27. Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259 (Pubitemid 23302039)
28. Uchida T, Nakamura T, Hashimoto N et al (2005) Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 11:175-182 (Pubitemid 40321353)
29. Georgia S, Bhushan A (2006) p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes 55:2950-2956 (Pubitemid 44923631)
30. Woods YL, Rena G, Morrice N et al (2001) The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem J 355:597-607 (Pubitemid 32434075)
31. Frayling TM, Wiltshire S, Hitman GA et al (2003) Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11. Diabetes 52:1857-1863 (Pubitemid 36792479)
32. Rohner-Jeanrenaud F, Bobbioni E, Ionescu E, Sauter JF, Jeanrenaud B (1983) Central nervous system regulation of insulin secretion. Adv Metab Disord 10:193-220
33. Fotaki V, Martinez de Lagrán M, Estivill X, Arbonés M, Dierssen M (2004) Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. Behav Neurosci 118:815-821 (Pubitemid 38970502)
34. Bhushan A, Itoh N, Kato S et al (2001) Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128:5109-5117 (Pubitemid 34083036)
35. Wilson ME, Yang KY, Kalousova A et al (2005) The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes 54:3402-3409 (Pubitemid 43334329)
36. Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX (2008) Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol 199:287-298
37. Hong SH, Lee KS, Kwak SJ et al (2012) Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet 8:e1002857
38. Hashimoto N, Kido Y, Uchida T et al (2006) Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet 38:589-593
39. Fernandez-Martinez J, Vela EM, Tora-Ponsioen M, Ocana OH, Nieto MA, Galceran J (2009) Attenuation of Notch signalling by the Down-syndrome- associated kinase DYRK1A. J Cell Sci 122:1574-1583
40. Hammerle B, Ulin E, Guimera J, Becker W, Guillemot F, Tejedor FJ (2011) Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling. Development 138:2543-2554
41. Martin DE, Soulard A, Hall MN (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119:969-979 (Pubitemid 40037610)
42. Yang SB, Lee HY, Young DM et al (2012) Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl) 90:575-585
43. Wippich F, Bodenmiller B, Trajkovska MG, Wanka S, Aebersold R, Pelkmans L (2013) Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell 152:791-805