-
1
-
-
0038725685
-
Negative selection-clearing out the bad apples from the T-cell repertoire
-
Palmer E. Negative selection-clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 2003, 3:383-391. 10.1038/nri1085.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 383-391
-
-
Palmer, E.1
-
2
-
-
33646165128
-
Acentral role for central tolerance
-
Kyewski B., Klein L. Acentral role for central tolerance. Annu. Rev. Immunol. 2006, 24:571-606. 10.1146/annurev.immunol.23.021704.115601.
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 571-606
-
-
Kyewski, B.1
Klein, L.2
-
3
-
-
84913594338
-
Population and single-cell genomics reveal the Aire dependency, relief from polycomb silencing, and distribution of self-antigen expression in thymic epithelia
-
Sansom S.N., Shikama-Dorn N., Zhanybekova S., Nusspaumer G., Macaulay I.C., Deadman M.E., Heger A., Ponting C.P., Holländer G.A. Population and single-cell genomics reveal the Aire dependency, relief from polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res. 2014, 24(12):1918-1931. 10.1101/gr.171645.113.
-
(2014)
Genome Res.
, vol.24
, Issue.12
, pp. 1918-1931
-
-
Sansom, S.N.1
Shikama-Dorn, N.2
Zhanybekova, S.3
Nusspaumer, G.4
Macaulay, I.C.5
Deadman, M.E.6
Heger, A.7
Ponting, C.P.8
Holländer, G.A.9
-
4
-
-
0037084784
-
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
-
Ramsey C., Winqvist O., Puhakka L., Halonen M., Moro A., Eskelin P., Pelto-Huikko M., Peltonen L. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 2002, 11:397-409. 10.1093/hmg/11.4.397.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 397-409
-
-
Ramsey, C.1
Winqvist, O.2
Puhakka, L.3
Halonen, M.4
Moro, A.5
Eskelin, P.6
Pelto-Huikko, M.7
Peltonen, L.8
-
5
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002, 298:1395-1401. 10.1126/science.1075958.
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
Chen, Z.4
Berzins, S.P.5
Turley, S.J.6
von Boehmer, H.7
Bronson, R.8
Dierich, A.9
Benoist, C.10
Mathis, D.11
-
6
-
-
84901487911
-
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
-
Klein L., Kyewski B., Allen P.M., Hogquist K.A. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat. Rev. Immunol. 2014, 14(6):377-391. 10.1038/nri3667.
-
(2014)
Nat. Rev. Immunol.
, vol.14
, Issue.6
, pp. 377-391
-
-
Klein, L.1
Kyewski, B.2
Allen, P.M.3
Hogquist, K.A.4
-
7
-
-
33748866909
-
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
-
Bonasio R., Scimone M.L., Schaerli P., Grabie N., Lichtman A.H., von Andrian U.H. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat. Immunol. 2006, 7:1092-1100. 10.1038/ni1385.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1092-1100
-
-
Bonasio, R.1
Scimone, M.L.2
Schaerli, P.3
Grabie, N.4
Lichtman, A.H.5
von Andrian, U.H.6
-
8
-
-
84858786391
-
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance
-
Hadeiba H., Lah K., Edalati A., Oderup C., Habtezion A., Pachynski R., Nguyen L., Ghodsi A., Adler S., Butcher E.C. Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity 2012, 36(3):438-450. 10.1016/j.immuni.2012.01.017.
-
(2012)
Immunity
, vol.36
, Issue.3
, pp. 438-450
-
-
Hadeiba, H.1
Lah, K.2
Edalati, A.3
Oderup, C.4
Habtezion, A.5
Pachynski, R.6
Nguyen, L.7
Ghodsi, A.8
Adler, S.9
Butcher, E.C.10
-
9
-
-
84855995571
-
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
-
Giraud M., Yoshida H., Abramson J., Rahl P.B., Young R.A., Mathis D., Benoist C. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc. Natl. Acad. Sci. U S A 2012, 109:535-540. 10.1073/pnas.1119351109.
-
(2012)
Proc. Natl. Acad. Sci. U S A
, vol.109
, pp. 535-540
-
-
Giraud, M.1
Yoshida, H.2
Abramson, J.3
Rahl, P.B.4
Young, R.A.5
Mathis, D.6
Benoist, C.7
-
10
-
-
73149115486
-
Aire's partners in the molecular control of immunological tolerance
-
Abramson J., Giraud M., Benoist C., Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell 2010, 140:123-135. 10.1016/j.cell.2009.12.030.
-
(2010)
Cell
, vol.140
, pp. 123-135
-
-
Abramson, J.1
Giraud, M.2
Benoist, C.3
Mathis, D.4
-
11
-
-
70450192681
-
AIRE activated tissue specific genes have histone modifications associated with inactive chromatin
-
Org T., Rebane A., Kisand K., Laan M., Haljasorg U., Andreson R., Peterson P. AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum. Mol. Genet. 2009, 18:4699-4710. 10.1093/hmg/ddp433.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4699-4710
-
-
Org, T.1
Rebane, A.2
Kisand, K.3
Laan, M.4
Haljasorg, U.5
Andreson, R.6
Peterson, P.7
-
12
-
-
77952088288
-
Increased apoptosis after autoimmune regulator expression in epithelial cells revealed by a combined quantitative proteomics approach
-
Colomé N., Collado J., Bech-Serra J.J., Liiv I., Antón L.C., Peterson P., Canals F., Jaraquemada D., Alvarez I. Increased apoptosis after autoimmune regulator expression in epithelial cells revealed by a combined quantitative proteomics approach. J.Proteome Res. 2010, 9(5):2600-2609. 10.1021/pr100044d.
-
(2010)
J.Proteome Res.
, vol.9
, Issue.5
, pp. 2600-2609
-
-
Colomé, N.1
Collado, J.2
Bech-Serra, J.J.3
Liiv, I.4
Antón, L.C.5
Peterson, P.6
Canals, F.7
Jaraquemada, D.8
Alvarez, I.9
-
13
-
-
0346599403
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
-
Aaltonen J., Björses P., Perheentupa J., Horelli-Kuitunen N., Palotie A., Peltonen L., Lee Y.S., Francis F., Henning S., Thiel C., Leharach H., Yaspo M.L. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 1997, 17:399-403. 10.1038/ng1297-399.
-
(1997)
Nat. Genet.
, vol.17
, pp. 399-403
-
-
Aaltonen, J.1
Björses, P.2
Perheentupa, J.3
Horelli-Kuitunen, N.4
Palotie, A.5
Peltonen, L.6
Lee, Y.S.7
Francis, F.8
Henning, S.9
Thiel, C.10
Leharach, H.11
Yaspo, M.L.12
-
14
-
-
34147128054
-
Highly variable expression of tissue-restricted self-antigens in human thymus: Implications for self-tolerance and autoimmunity
-
Taubert R., Schwendemann J., Kyewski B. Highly variable expression of tissue-restricted self-antigens in human thymus: Implications for self-tolerance and autoimmunity. Eur. J. Immunol. 2007, 37:838-848. 10.1002/eji.200636962.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 838-848
-
-
Taubert, R.1
Schwendemann, J.2
Kyewski, B.3
-
15
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
Derbinski J., Schulte A., Kyewski B., Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001, 2:1032-1039. 10.1038/ni723.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1032-1039
-
-
Derbinski, J.1
Schulte, A.2
Kyewski, B.3
Klein, L.4
-
16
-
-
84883798955
-
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
-
Pinto S., Michel C., Schmidt-Glenewinkel H., Harder N., Rohr K., Wild S., Brors B., Kyewski B. Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proc. Natl. Acad. Sci. U S A 2013, 110(37):E3497-E3505. 10.1073/pnas.1308311110.
-
(2013)
Proc. Natl. Acad. Sci. U S A
, vol.110
, Issue.37
, pp. E3497-E3505
-
-
Pinto, S.1
Michel, C.2
Schmidt-Glenewinkel, H.3
Harder, N.4
Rohr, K.5
Wild, S.6
Brors, B.7
Kyewski, B.8
-
17
-
-
84907830964
-
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells
-
Pinto S., Sommermeyer D., Michel C., Wilde S., Schendel D., Uckert W., Blankenstein T., Kyewski B. Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells. Eur. J. Immunol. 2014, 44(9):2811-2821. 10.1002/eji.201444499.
-
(2014)
Eur. J. Immunol.
, vol.44
, Issue.9
, pp. 2811-2821
-
-
Pinto, S.1
Sommermeyer, D.2
Michel, C.3
Wilde, S.4
Schendel, D.5
Uckert, W.6
Blankenstein, T.7
Kyewski, B.8
-
18
-
-
84879626985
-
Exploring the MHC-peptide matrix of central tolerance in the human thymus
-
Adamopoulou E., Tenzer S., Hillen N., Klug P., Rota I.A., Tietz S., Gebhardt M., Stevanovic S., Schild H., Tolosa E., Melms A., Stoeckle C. Exploring the MHC-peptide matrix of central tolerance in the human thymus. Nat. Commun. 2013, 4:1-9. 10.1038/ncomms3039.
-
(2013)
Nat. Commun.
, vol.4
, pp. 1-9
-
-
Adamopoulou, E.1
Tenzer, S.2
Hillen, N.3
Klug, P.4
Rota, I.A.5
Tietz, S.6
Gebhardt, M.7
Stevanovic, S.8
Schild, H.9
Tolosa, E.10
Melms, A.11
Stoeckle, C.12
-
19
-
-
84883497302
-
Composition of the HLA-DR-associated human thymus peptidome
-
Collado J.A., Alvarez I., Ciudad M.T., Espinosa G., Canals F., Pujol-Borrell R., Carrascal M., Abian J., Jaraquemada D. Composition of the HLA-DR-associated human thymus peptidome. Eur. J. Immunol. 2013, 43(9):2273-2282. 10.1002/eji.201243280.
-
(2013)
Eur. J. Immunol.
, vol.43
, Issue.9
, pp. 2273-2282
-
-
Collado, J.A.1
Alvarez, I.2
Ciudad, M.T.3
Espinosa, G.4
Canals, F.5
Pujol-Borrell, R.6
Carrascal, M.7
Abian, J.8
Jaraquemada, D.9
-
20
-
-
84885357778
-
Peptides presented by HLA class I molecules in the human thymus
-
Espinosa G., Collado J.A., Scholz E., Mestre-Ferrer A., Kuse N., Takiguchi M., Carrascal M., Canals F., Pujol-Borrell R., Jaraquemada D., Alvarez I. Peptides presented by HLA class I molecules in the human thymus. J.Proteomics 2013, 94:23-36. 10.1016/j.jprot.2013.08.023.
-
(2013)
J.Proteomics
, vol.94
, pp. 23-36
-
-
Espinosa, G.1
Collado, J.A.2
Scholz, E.3
Mestre-Ferrer, A.4
Kuse, N.5
Takiguchi, M.6
Carrascal, M.7
Canals, F.8
Pujol-Borrell, R.9
Jaraquemada, D.10
Alvarez, I.11
-
21
-
-
68849128050
-
An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans
-
Hou Y., DeVoss J., Dao V., Kwek S., Simko J.P., McNeel D.G., Anderson M.S., Fong L. An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J.Clin. Invest. 2009, 119:2031-2041. 10.1172/JCI38332.
-
(2009)
J.Clin. Invest.
, vol.119
, pp. 2031-2041
-
-
Hou, Y.1
DeVoss, J.2
Dao, V.3
Kwek, S.4
Simko, J.P.5
McNeel, D.G.6
Anderson, M.S.7
Fong, L.8
-
22
-
-
66249105681
-
Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals
-
Derfuss T., Parikh K., Velhin S., Braun M., Mathey E., Krumbholz M., Kümpfel T., Moldenhauer A., Rader C., Sonderegger P., Pöllmann W., Tiefenthaller C., Bauer J., Lassmann H., Wekerle H., Karagogeos D., Hohlfeld R., Linington C., Meinl E. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc. Natl. Acad. Sci. U S A 2009, 106:8302-8307. 10.1073/pnas.0901496106.
-
(2009)
Proc. Natl. Acad. Sci. U S A
, vol.106
, pp. 8302-8307
-
-
Derfuss, T.1
Parikh, K.2
Velhin, S.3
Braun, M.4
Mathey, E.5
Krumbholz, M.6
Kümpfel, T.7
Moldenhauer, A.8
Rader, C.9
Sonderegger, P.10
Pöllmann, W.11
Tiefenthaller, C.12
Bauer, J.13
Lassmann, H.14
Wekerle, H.15
Karagogeos, D.16
Hohlfeld, R.17
Linington, C.18
Meinl, E.19
-
23
-
-
80051705017
-
Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance
-
Colobran R., Armengol M.P., Faner R., Gärtner M., Tykocinski L.O., Lucas A., Ruiz M., Juan M., Kyewski B., Pujol-Borrell R. Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance. Hum. Mol. Genet. 2011, 20(17):3415-3423. 10.1093/hmg/ddr247.
-
(2011)
Hum. Mol. Genet.
, vol.20
, Issue.17
, pp. 3415-3423
-
-
Colobran, R.1
Armengol, M.P.2
Faner, R.3
Gärtner, M.4
Tykocinski, L.O.5
Lucas, A.6
Ruiz, M.7
Juan, M.8
Kyewski, B.9
Pujol-Borrell, R.10
-
24
-
-
0036137241
-
ProPred: prediction of HLA-DR binding sites
-
Singh H., Raghava G.P. ProPred: prediction of HLA-DR binding sites. Bioinformatics 2001, 17(12):1236-1237.
-
(2001)
Bioinformatics
, vol.17
, Issue.12
, pp. 1236-1237
-
-
Singh, H.1
Raghava, G.P.2
-
25
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
Derbinski J., Gäbler J., Brors B., Tierling S., Jonnakuty S., Hergenhahn M., Peltonen L., Walter J., Kyewski B. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J.Exp. Med. 2005, 202:33-45. 10.1084/jem.20050471.
-
(2005)
J.Exp. Med.
, vol.202
, pp. 33-45
-
-
Derbinski, J.1
Gäbler, J.2
Brors, B.3
Tierling, S.4
Jonnakuty, S.5
Hergenhahn, M.6
Peltonen, L.7
Walter, J.8
Kyewski, B.9
-
26
-
-
77954354166
-
The auto-antigen repertoire in myasthenia gravis
-
Vrolix K., Fraussen J., Molenaar P.C., Losen M., Somers V., Stinissen P., De Baets M.H., Martínez-Martínez P. The auto-antigen repertoire in myasthenia gravis. Autoimmunity 2010, 43:380-400. 10.3109/08916930903518073.
-
(2010)
Autoimmunity
, vol.43
, pp. 380-400
-
-
Vrolix, K.1
Fraussen, J.2
Molenaar, P.C.3
Losen, M.4
Somers, V.5
Stinissen, P.6
De Baets, M.H.7
Martínez-Martínez, P.8
-
27
-
-
84907982768
-
Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
-
Perry J.S., Lio C.W., Kau A.L., Nutsch K., Yang Z., Gordon J.I., Murphy K.M., Hsieh C.S. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 2014, 41(3):414-426. 10.1016/j.immuni.2014.08.007.
-
(2014)
Immunity
, vol.41
, Issue.3
, pp. 414-426
-
-
Perry, J.S.1
Lio, C.W.2
Kau, A.L.3
Nutsch, K.4
Yang, Z.5
Gordon, J.I.6
Murphy, K.M.7
Hsieh, C.S.8
-
28
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
Anderson M.S., Venanzi E.S., Chen Z., Berzins S.P., Benoist C., Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity 2005, 23(2):227-239. 10.1016/j.immuni.2005.07.005.
-
(2005)
Immunity
, vol.23
, Issue.2
, pp. 227-239
-
-
Anderson, M.S.1
Venanzi, E.S.2
Chen, Z.3
Berzins, S.P.4
Benoist, C.5
Mathis, D.6
-
29
-
-
43049128502
-
Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
-
Su M.A., Giang K., Zumer K., Jiang H., Oven I., Rinn J.L., Devoss J.J., Johannes K.P., Lu W., Gardner J., Chang A., Bubulya P., Chang H.Y., Peterlin B.M., Anderson M.S. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J.Clin. Invest. 2008, 118(5):1712-1726. 10.1172/JCI34523.
-
(2008)
J.Clin. Invest.
, vol.118
, Issue.5
, pp. 1712-1726
-
-
Su, M.A.1
Giang, K.2
Zumer, K.3
Jiang, H.4
Oven, I.5
Rinn, J.L.6
Devoss, J.J.7
Johannes, K.P.8
Lu, W.9
Gardner, J.10
Chang, A.11
Bubulya, P.12
Chang, H.Y.13
Peterlin, B.M.14
Anderson, M.S.15
-
30
-
-
84907485548
-
Autoimmune predisposition in Down syndrome may result from a partial central tolerance failure due to insufficient intrathymic expression of AIRE and peripheral antigens
-
Giménez-Barcons M., Casteràs A., Armengol M.del P., Porta E., Correa P.A., Marín A., Pujol-Borrell R., Colobran R. Autoimmune predisposition in Down syndrome may result from a partial central tolerance failure due to insufficient intrathymic expression of AIRE and peripheral antigens. J.Immunol. 2014;15, 193(8):3872-3879. 10.4049/jimmunol.1400223.
-
(2014)
J.Immunol.
, vol.193
, Issue.8
, pp. 3872-3879
-
-
Giménez-Barcons, M.1
Casteràs, A.2
Armengol, M.D.P.3
Porta, E.4
Correa, P.A.5
Marín, A.6
Pujol-Borrell, R.7
Colobran, R.8
|