Autoimmune predisposition in down syndrome may result from a partial central tolerance failure due to insufficient intrathymic expression of AIRE and peripheral antigens

Journal of Immunology

Volumn 193, Issue 8, 2014, Pages 3872-3879

  Giménez Barcons, Mireia ^a   Casteràs, Anna ^a   Del Pilar Armengol, Maria ^b   Porta, Eduard ^b   Correa, Paula A ^b   Marín, Ana ^a   Pujol Borrell, Ricardo ^a,c   Colobran, Roger ^a,c  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b FUNDACIÓ INSTITUT D INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; KALLIKREIN; KALLIKREIN RELATED PEPTIDASE 3; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA1; PROTEOLIPID PROTEIN; PROTEOLIPID PROTEIN 1; RETINA S ANTIGEN; THYROGLOBULIN; THYROTROPIN RECEPTOR; TISSUE ANTIGEN; UNCLASSIFIED DRUG; TRANSCRIPTION FACTOR;

AIRE GENE; ALLELE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE THYROIDITIS; AUTOIMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE PREDISPOSITION; DOWN SYNDROME; FEMALE; FLUORESCENCE MICROSCOPY; GENE DUPLICATION; GENE EXPRESSION REGULATION; GRAVES DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHYROIDISM; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; INFANT; MALE; MOLECULAR PATHOLOGY; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; SCHOOL CHILD; THYMUS; TISSUE SPECIFICITY; TRISOMY 21; ADOLESCENT; ADULT; AUTOIMMUNE DISEASE; BIOSYNTHESIS; COMPLICATION; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; YOUNG ADULT;

ADOLESCENT; ADULT; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CENTRAL TOLERANCE; CHILD; CHILD, PRESCHOOL; DOWN SYNDROME; FEMALE; GENE EXPRESSION; HUMANS; HYPOTHYROIDISM; INFANT; MALE; THYMUS GLAND; THYROGLOBULIN; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84907485548     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400223     Document Type: Article

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