In situ molecular elucidation of drug supersaturation achieved by nano-sizing and amorphization of poorly water-soluble drug

European Journal of Pharmaceutical Sciences

Volumn 77, Issue , 2015, Pages 79-89

  Ueda, Keisuke ^a   Higashi, Kenjirou ^a   Yamamoto, Keiji ^a   Moribe, Kunikazu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Amorphous drug; Crystallization inhibition; Nanoparticles; NMR measurement; Supersaturated solution

Indexed keywords

CARBAMAZEPINE; DODECYL SULFATE SODIUM; HYDROXYPROPYLMETHYLCELLULOSE; NANOPARTICLE; DRUG; WATER;

AREA UNDER THE CURVE; ARTICLE; CHEMICAL ENVIRONMENT; CRYSTAL; DIALYSIS MEMBRANE; DISPERSION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SOLUBILITY; GRINDING; LIGHT SCATTERING; MECHANICAL STRESS; MEMBRANE FILTER; MICELLE; MOLECULAR INTERACTION; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; SOLID STATE; SPRAY DRYING; X RAY DIFFRACTION; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POWDER DIFFRACTION; SOLUBILITY;

CARBAMAZEPINE; CARBON-13 MAGNETIC RESONANCE SPECTROSCOPY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYPROMELLOSE DERIVATIVES; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; POWDER DIFFRACTION; SODIUM DODECYL SULFATE; SOLUBILITY; WATER;

EID: 84930959177     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.05.027     Document Type: Article

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