Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement

International Journal of Pharmaceutics

Volumn 437, Issue 1-2, 2012, Pages 288-293

  Frank, Kerstin J ^a,c   Rosenblatt, Karin M ^b   Westedt, Ulrich ^b   Hölig, Peter ^b   Rosenberg, Jörg ^b   Mägerlein, Markus ^b   Fricker, Gert ^c   Brandl, Martin ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ABBOTT GMBH AND CO KG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

FaSSIF; Permeability; Solid dispersion; Solubility; Supersaturation

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; CARBOXYFLUORESCEIN;

AMORPHOUS SOLID DISPERSION; AQUEOUS SOLUTION; ARTICLE; CELL ASSAY; CELL VIABILITY; CENTRIFUGATION; CRYSTAL; DIALYSIS; DISPERSION; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; IN VITRO STUDY; INTESTINE FLUID; MOLECULAR STABILITY; PERMEABILITY BARRIER; PRIORITY JOURNAL; SOLID STATE; SOLUBILIZATION;

CACO-2 CELLS; CELL SURVIVAL; DOSAGE FORMS; HUMANS; INDAZOLES; PERMEABILITY; SOLUBILITY; TRPV CATION CHANNELS; UREA;

EID: 84866732706     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.014     Document Type: Article

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