MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors

Neuropharmacology

Volumn 95, Issue , 2015, Pages 479-491

  Irie, Tomohiko ^a   Kikura Hanajiri, Ruri ^a   Usami, Makoto ^a   Uchiyama, Nahoko ^a   Goda, Yukihiro ^a   Sekino, Yuko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Cannabinoid receptor type 1; Cerebellum; MAM 2201; Neurotransmitter release; Purkinje cell; Synthetic cannabinoids

Indexed keywords

3 (1 NAPHTHOYL) 1 PENTYLINDOLE; 4 AMINOBUTYRIC ACID; CALCIUM ION; CANNABINOID; CANNABINOID 1 RECEPTOR; DRONABINOL; GLUTAMIC ACID; UNCLASSIFIED DRUG; [1 (5 FLUOROPENTYL) 1H INDOL 3 YL](4 METHYL 1 NAPHTHALENYL)METHANONE; 1-(5-FLUOROPENTYL)-3-(4-METHYL-1-NAPHTHOYL)INDOLE; 1-PENTYL-3-(1-NAPHTHOYL)INDOLE; CALCIUM; INDOLE DERIVATIVE; NAPHTHALENE DERIVATIVE; PRESYNAPTIC RECEPTOR; PSYCHOTROPIC AGENT; STREET DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CALCIUM TRANSPORT; CELL ASSAY; CELL FUNCTION; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PURKINJE CELL; SIGNAL TRANSDUCTION; WHOLE CELL PATCH CLAMP; AGONISTS; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; INTERNEURON; MEMBRANE POTENTIAL; METABOLISM; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SYNAPTIC TRANSMISSION; TISSUE CULTURE TECHNIQUE; TUMOR CELL LINE;

ANIMALS; CALCIUM; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRONABINOL; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HUMANS; INDOLES; INTERNEURONS; MEMBRANE POTENTIALS; MICE; NAPHTHALENES; PATCH-CLAMP TECHNIQUES; PSYCHOTROPIC DRUGS; PURKINJE CELLS; RECEPTOR, CANNABINOID, CB1; RECEPTORS, PRESYNAPTIC; STREET DRUGS; SYNAPTIC TRANSMISSION; TISSUE CULTURE TECHNIQUES;

EID: 84930943970     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.02.025     Document Type: Article

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