Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site

Neuropharmacology

Volumn 95, Issue , 2015, Pages 459-467

  Middendorp, Simon J ^a   Maldifassi, Maria C ^a   Baur, Roland ^a   Sigel, Erwin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Benzodiazepine; Chloride channels; Electrophysiology; GABAA receptors; Positive allosteric modulator; Xenopus oocyte

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; SJM 3; UNCLASSIFIED DRUG; FLUMAZENIL; GABAERGIC RECEPTOR AFFECTING AGENT; ISOPROTEIN; QUINOLINE DERIVATIVE; RECOMBINANT PROTEIN; SJM-3 COMPOUND; THIAZOLE DERIVATIVE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; GABAERGIC SYSTEM; HEK293 CELL LINE; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS; ANIMAL; BINDING SITE; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; MEMBRANE POTENTIAL; METABOLISM; MUTATION; NERVE CELL; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; RADIOASSAY;

ALLOSTERIC REGULATION; ANIMALS; BENZODIAZEPINES; BINDING SITES; DIAZEPAM; FLUMAZENIL; GABA AGENTS; GAMMA-AMINOBUTYRIC ACID; HEK293 CELLS; HUMANS; MEMBRANE POTENTIALS; MUTATION; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; QUINOLINES; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; THIAZOLES; TRANSFECTION; XENOPUS LAEVIS;

EID: 84930943469     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.04.027     Document Type: Article

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