Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of γ-aminobutyric acid type A receptors: Superposition of different allosteric modulators

Journal of Biological Chemistry

Volumn 282, Issue 36, 2007, Pages 26316-26325

  Tan, Kelly R ^a   Gonthier, Anne ^b   Baur, Roland ^a   Ernst, Margot ^c   Goeldner, Maurice ^b   Sigel, Erwin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c Medical University of Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; ANTICONVULSANT EFFECTS; BENZODIAZEPINES; CHEMICAL COUPLING REACTIONS;

AMINO ACIDS; BINDING SITES; GAMMA RAYS; LIGANDS; MUSCLE; REACTION KINETICS;

PROTEINS;

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; CYSTEINE; DIAZEPINE DERIVATIVE; IMIDAZOBENZODIAZEPINE; ISOTHIOCYANIC ACID; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; COUPLING FACTOR; EMBRYO; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; WILD TYPE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; BENZODIAZEPINES; CENTRAL NERVOUS SYSTEM AGENTS; CYSTEINE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN ISOFORMS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548810453     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702153200     Document Type: Article

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