MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure

Toxicology and Applied Pharmacology

Volumn 287, Issue 1, 2015, Pages 35-42

  Kosten, Ilona J ^a   Spiekstra, Sander W ^a   de Gruijl, Tanja D ^a   Gibbs, Susan ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Allergen; Chemokine; Irritant; Langerhans cell; Macrophage; Skin equivalent

Indexed keywords

ALLERGEN; CHEMOKINE RECEPTOR CXCR4; CINNAMALDEHYDE; INTERLEUKIN 10; IRRITANT AGENT; NEUTRALIZING ANTIBODY; NICKEL SULFATE; POLYSORBATE 80; RESORCINOL; TRITON X 100; BIOLOGICAL MARKER; CHEMOKINE;

ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DERMIS; EPIDERMIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; LANGERHANS CELL; MACROPHAGE; PHENOTYPIC PLASTICITY; REAL TIME POLYMERASE CHAIN REACTION; SKIN; SKIN FIBROBLAST; TOXIC CONCENTRATION; CELL DIFFERENTIATION; CELL LINE; CELL MOTION; COCULTURE; COMPARATIVE STUDY; DRUG EFFECTS; FIBROBLAST; METABOLISM; PATHOLOGY; PHENOTYPE;

ALLERGENS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CHEMOKINES; COCULTURE TECHNIQUES; EPIDERMIS; FIBROBLASTS; HUMANS; IRRITANTS; KERATINOCYTES; LANGERHANS CELLS; PHENOTYPE;

EID: 84930939815     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.05.017     Document Type: Article

References (37)

1. Adler S., Basketter D., Creton S., Pelkonen O., van, Benthem J., Zuang V., Andersen K.E., Angers-Loustau A., Aptula A., Bal-Price A., Benfenati E., Bernauer U., Bessems J., Bois F.Y., Boobis A., Brandon E., Bremer S., Broschard T., Casati S., Coecke S., Corvi R., Cronin M., Daston G., Dekant W., Felter S., Grignard E., Gundert-Remy U., Heinonen T., Kimber I., Kleinjans J., Komulainen H., Kreiling R., Kreysa J., Leite S.B., Loizou G., Maxwell G., Mazzatorta P., Munn S., Pfuhler S., Phrakonkham P., Piersma A., Poth A., Prieto P., Repetto G., Rogiers V., Schoeters G., Schwarz M., Serafimova R., Tahti H., Testai E., van, Delft J., van, Loveren H., Vinken M., Worth A., Zaldivar J.M. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch. Toxicol. 2011, 85:367-485.
2. Banchereau J., Thompson-Snipes L., Zurawski S., Blanck J.P., Cao Y., Clayton S., Gorvel J.P., Zurawski G., Klechevsky E. The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming. Blood 2012, 119:5742-5749.
3. Bechetoille N., Dezutter-Dambuyant C., Damour O., Andre V., Orly I., Perrier E. Effects of solar ultraviolet radiation on engineered human skin equivalent containing both Langerhans cells and dermal dendritic cells. Tissue Eng. 2007, 13:2667-2679.
4. Chu C.C., Ali N., Karagiannis P., Di Meglio P., Skowera A., Napolitano L., Barinaga G., Grys K., Sharif-Paghaleh E., Karagiannis S.N., Peakman M., Lombardi G., Nestle F.O. Resident CD141 (BDCA3)+dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. J. Exp. Med. 2012, 209:935-945.
5. de Gruijl T.D., Sombroek C.C., Lougheed S.M., Oosterhoff D., Buter J., van den Eertwegh A.J., Scheper R.J., Pinedo H.M. A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance. J. Immunol. 2006, 176:7232-7242.
6. Dezutter-Dambuyant C., Black A., Bechetoille N., Bouez C., Marechal S., Auxenfans C., Cenizo V., Pascal P., Perrier E., Damour O. Evolutive skin reconstructions: from the dermal collagen-glycosaminoglycan-chitosane substrate to an immunocompetent reconstructed skin. Biomed. Mater. Eng. 2006, 16:S85-S94.
7. Diao J., Mikhailova A., Tang M., Gu H., Zhao J., Cattral M.S. Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells. Blood 2012, 119:4919-4927.
8. dos Santos G.G., Reinders J., Ouwehand K., Rustemeyer T., Scheper R.J., Gibbs S. Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol. Appl. Pharmacol. 2009, 236:372-382.
9. Facy V., Flouret V., Regnier M., Schmidt R. Reactivity of Langerhans cells in human reconstructed epidermis to known allergens and UV radiation. Toxicol. In Vitro 2005, 19:787-795.
10. Gibbs S., Corsini E., Spiekstra S.W., Galbiati V., Fuchs H.W., Degeorge G., Troese M., Hayden P., Deng W., Roggen E. An epidermal equivalent assay for identification and ranking potency of contact sensitizers. Toxicol. Appl. Pharmacol. 2013, 272:529-541.
11. Guironnet G., Dezutter-Dambuyant C., Gaudillere A., Marechal S., Schmitt D., Peguet-Navarro J. Phenotypic and functional outcome of human monocytes or monocyte-derived dendritic cells in a dermal equivalent. J. Invest. Dermatol. 2001, 116:933-939.
12. Huh D., Matthews B.D., Mammoto A., Montoya-Zavala M., Hsin H.Y., Ingber D.E. Reconstituting organ-level lung functions on a chip. Science 2010, 328:1662-1668.
13. Jacobs J.J., Lehe C.L., Hasegawa H., Elliott G.R., Das P.K. Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration. Exp. Dermatol. 2006, 15:432-440.
14. Kroeze K.L., Boink M.A., Sampat-Sardjoepersad S.C., Waaijman T., Scheper R.J., Gibbs S. Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3. J. Invest. Dermatol. 2012, 132:216-225.
15. Larsson K., Lindstedt M., Borrebaeck C.A. Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells. Immunology 2006, 117:156-166.
16. Lindenberg J.J., Oosterhoff D., Sombroek C.C., Lougheed S.M., Hooijberg E., Stam A.G., Santegoets S.J., Tijssen H.J., Buter J., Pinedo H.M., van den Eertwegh A.J., Scheper R.J., Koenen H.J., van de Ven, R., de Gruijl T.D. IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation. PLoS One 2013, 8:e70237.
17. Marks J.G., Zaino R.J., Bressler M.F., Williams J.V. Changes in lymphocyte and Langerhans cell populations in allergic and irritant contact dermatitis. Int. J. Dermatol. 1987, 26:354-357.
18. Masterson A.J., Sombroek C.C., de Gruijl T.D., Graus Y.M., van der Vliet H.J., Lougheed S.M., van den Eertwegh A.J., Pinedo H.M., Scheper R.J. MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors. Blood 2002, 100:701-703.
19. Oosterhoff D., Heusinkveld M., Lougheed S.M., Kosten I.J., Lindstedt M., Bruijns S.C., van Es T., van Kooyk Y., van der Burg, S.H., de Gruijl T.D. Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans. J. Immunol. 2013, 190:3338-3345.
20. Ouwehand K., Santegoets S.J., Bruynzeel D.P., Scheper R.J., de Gruijl T.D., Gibbs S. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur. J. Immunol. 2008, 38:3050-3059.
21. Ouwehand K., Scheper R.J., de Gruijl T.D., Gibbs S. Epidermis-to-dermis migration of immature Langerhans cells upon topical irritant exposure is dependent on CCL2 and CCL5. Eur. J. Immunol. 2010, 40:2026-2034.
22. Ouwehand K., Spiekstra S.W., Reinders J., Scheper R.J., de Gruijl T.D., Gibbs S. Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol. In Vitro 2010, 24:578-585.
23. Ouwehand K., Oosterhoff D., Breetveld M., Scheper R.J., de Gruijl T.D., Gibbs S. Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype. J. Invest. Dermatol. 2011, 131:418-425.
24. Ouwehand K., Spiekstra S.W., Waaijman T., Scheper R.J., de Gruijl T.D., Gibbs S. Technical advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration. J. Leukoc. Biol. 2011, 90:1027-1033.
25. Ouwehand K., Spiekstra S.W., Waaijman T., Breetveld M., Scheper R.J., de Gruijl T.D., Gibbs S. CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents. Eur. J. Cell Biol. 2012, 91:765-773.
26. Regnier M., Staquet M.J., Schmitt D., Schmidt R. Integration of Langerhans cells into a pigmented reconstructed human epidermis. J. Invest. Dermatol. 1997, 109:510-512.
27. Roggen E.L. In vitro approaches for detection of chemical sensitization. Basic Clin. Pharmacol. Toxicol. 2014, 115:32-40.
28. Santegoets S.J., Masterson A.J., van der Sluis P.C., Lougheed S.M., Fluitsma D.M., van den Eertwegh A.J., Pinedo H.M., Scheper R.J., de Gruijl T.D. A CD34(+) human cell line model of myeloid dendritic cell differentiation: evidence for a CD14(+)CD11b(+) Langerhans cell precursor. J. Leukoc. Biol. 2006, 80:1337-1344.
29. Santegoets S.J., van den Eertwegh A.J., van de Loosdrecht A.A., Scheper R.J., de Gruijl T.D. Human dendritic cell line models for DC differentiation and clinical DC vaccination studies. J. Leukoc. Biol. 2008, 84:1364-1373.
30. Schaerli P., Willimann K., Ebert L.M., Walz A., Moser B. Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation. Immunity 2005, 23:331-342.
31. Schmidt M., Raghavan B., Muller V., Vogl T., Fejer G., Tchaptchet S., Keck S., Kalis C., Nielsen P.J., Galanos C., Roth J., Skerra A., Martin S.F., Freudenberg M.A., Goebeler M. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat. Immunol. 2010, 11:814-819.
32. Shortman K., Liu Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2002, 2:151-161.
33. Smola H., Thiekotter G., Fusenig N.E. Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. J. Cell Biol. 1993, 122(2):417-429.
34. Spiekstra S.W., Toebak M.J., Sampat-Sardjoepersad S., van Beek P.J., Boorsma D.M., Stoof T.J., von Blomberg B.M., Scheper R.J., Bruynzeel D.P., Rustemeyer T., Gibbs S. Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. Exp. Dermatol. 2005, 14:109-116.
35. Uchino T., Takezawa T., Ikarashi Y. Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane. Toxicol. In Vitro 2009, 23:333-337.
36. van de Ven R., van den Hout M.F., Lindenberg J.J., Sluijter B.J., van Leeuwen P.A., Lougheed S.M., Meijer S., van den Tol M.P., Scheper R.J., de Gruijl T.D. Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation. Blood 2011, 118:2502-2510.
37. van de Ven R., Verbrugge S.E., Reurs A.W., Bontkes H.J., Hooijberg E., Jansen G., Scheper R.J., Scheffer G.L., de Gruijl T.D. High susceptibility of c-KIT+CD34+ precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model. Cancer Immunol. Immunother. 2011, 60:943-951.