A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance

Journal of Immunology

Volumn 176, Issue 12, 2006, Pages 7232-7242

  De Gruijl, Tanja D ^a   Sombroek, Claudia C ^a   Lougheed, Sinéad M ^a   Oosterhoff, Dinja ^a   Buter, Jan ^a   Van Den Eertwegh, Alfons J M ^a   Scheper, Rik J ^a   Pinedo, Herbert M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD83 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 4;

ANTIGEN RECOGNITION; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CYTOKINE RELEASE; DENDRITIC CELL; EXPLANT; GENE SWITCHING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; LYMPHOID ORGAN; MACROPHAGE ACTIVATION; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; SKIN CELL; SKIN CULTURE; T LYMPHOCYTE ACTIVATION;

EID: 33744918280     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.12.7232     Document Type: Article

References (42)

1. Bhardwaj, N. 2001. Processing and presentation of antigens by dendritic cells: implications for vaccines. Trends Mol. Med. 7: 388-394.
2. Steinman, R. M., and M. C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 99: 351-358.
3. Jonuleit, H., E. Schmitt, K. Steinbrink, and A. H. Enk. 2001. Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 22: 394-400.
4. Lutz, M., and G. Schuler. 2002. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23: 445-449.
5. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767-811.
6. McLellan, A. D., A. Heiser, R. V. Sorg, D. B. Fearnley, and D. N. Hart. 1998. Dermal dendritic cells associated with T lymphocytes in normal human skin display an activated phenotype. J. Invest. Dermatol. 111: 841-849.
7. Sallusto, F., and A. Lanzavecchia. 2000. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev. 177: 134-140.
8. Lappin, M. B., J. M. Weiss, V. Delattre, B. Mai, H. Dittmar, C. Maier, K. Manke, S. Grabbe, S. Martin, and J. C. Simon. 1999. Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology 98: 181-188.
9. Barratt-Boyes, S. M., S. C. Watkins, and O. J. Finn. 1997. In vivo migration of dendritic cells differentiated in vitro: a chimpanzee model. J. Immunol. 158: 4543-4547.
10. Haig, D. M., J. Hopkins, and H. R. Miller. 1999. Local immune responses in afferent and efferent lymph. Immunology 96: 155-163.
11. Geissmann, F., M. C. Dieu-Nosjean, C. Dezutter, J. Valladeau, S. Kayal, M. Leborgne, N. Brousse, S. Saeland, and J. Davoust. 2002. Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin. J. Exp. Med. 196: 417-430.
12. + T cells resulting in a failure to lyse tumor cells. Blood 93: 1634-1642.
13. Enk, A. H., H. Jonuleit, J. Saloga, and J. Knop. 1997. Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int. J. Cancer. 73: 309-316.
14. Lukas, M., H. Stossel, L. Hefel, S. Imamura, P. Fritsch, N. T. Sepp, G. Schuler, and N. Romani. 1996. Human cutaneous dendritic cells migrate through dermal lymphatic vessels in a skin organ culture model. J. Invest. Dermatol. 106: 1293-1299.
15. de Gruijl, T. D., S. A. Luykx-de Bakker, B. W. Tillman, A. J. van den Eertwegh, J. Buter, S. M. Lougheed, G. J. van der Bij, A. M. Safer, H. J. Haisma, D. T. Curiel, et al. 2002. Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin expiants after in situ delivery of CD40-targeted adenoviral vectors. J. Immunol. 169: 5322-5331.
16. + cells differentiate into Langerhans cells. Nat. Immunol. 2: 1151-1158.
17. Sombroek, C. C., A. G. Stam, A. J. Masterson, S. M. Lougheed, M. J. Schakel, C. J. Meijer, H. M. Pinedo, A. J. van den Eertwegh, R. J. Scheper, and T. D. de Gruijl. 2002. Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J. Immunol. 168: 4333-4343.
18. Valladeau, J., V. Duvert-Frances, J. J. Pin, C. Dezutter-Dambuyant, C. Vincent, C. Massacrier, J. Vincent, K. Yoneda, J. Banchereau, C. Caux, et al. 1999. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur. J. Immunol. 29: 2695-2704.
19. Dzionek, A., A. Fuchs, P. Schmidt, S. Cremer, M. Zysk, S. Miltenyi, D. W. Buck, and J. Schmitz. 2000. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165: 6037-6046.
20. Dzionek, A., Y. Inagaki, K. Okawa, J. Nagafune, J. J. Rock, Y. Sohma, G. Winkels, M. Zysk, Y. Yamaguchi, and J. J. Schmitz. 2002. Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions. Hum. Immunol. 63: 1133-1148.
21. Tchou, I., O. Sabido, C. Lambert, L. Misery, O. Garraud, and C. Genin. 2003. Technique for obtaining highly enriched, quiescent immature Langerhans cells suitable for ex vivo assays. Immunol. Lett. 86: 7-14.
22. Larregina, A. T., and L. D. Falo, Jr. 2001. Dendritic cells in the context of skin immunity. In Dendritic Cells-Biology and Clinical Applications. M. T. Lotze and A. W. Thomson, eds. Academic Press, London, pp. 301-314.
23. Valladeau, J., O. Ravel, C. Dezutter-Dambuyam, K. Moore, M. Kleijmeer, Y. Liu, V. Duvert-Frances, C. Vincent, D. Schmitt, J. Davoust, et al. 2000. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12: 71-81.
24. Larregina, A. T., and L. D. Falo. 2005. Changing paradigms in cutaneous immunology: adapting with dendritic cells. J. Invest. Dermatol. 124: 1-12.
25. + T cell responses elicited by different subsets of human skin migratory dendritic cells. J. Immunol. 175: 7905-7915.
26. +) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting. J. Exp. Med. 196: 517-527.
27. Nestle, F. O., X. G. Zheng, C. B. Thompson, L. A. Turka, and B. J. Nickoloff. 1993. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J. Immunol. 151: 6535-6545.
28. Takahashi, K., K. Asagoe, J. Zaishun, H. Yanai, T. Yoshino, K. Hayashi, and T. Akagi. 1998. Heterogeneity of dendritic cells in human superficial lymph node: in vitro maturation of immature dendritic cells into mature or activated interdigitating reticulum cells. Am. J. Pathol. 153: 745-755.
29. Randolph, G. J. 2002. Is maturation required for Langerhans cell migration? J. Exp. Med. 196: 413-416.
30. Garg, S., A. Oran, J. Wajchman, S. Sasaki, C. H. Maris, J. A. Kapp, and J. Jacob. 2003. Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo. Nat. Immunol. 4: 907-912.
31. Ruedl, C., P. Koebel, M. Bachmann, M. Hess, and K. Karjalainen. 2000. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J. Immunol. 165: 4910-4916.
32. Brand, C. U., R. E. Hunger, N. Yawalkar, H. A. Gerber, T. Schaffner, and L. R. Braathen. 1999. Characterization of human skin-derived CD1a-positive lymph cells. Arch. Dermatol. Res. 291: 65-72.
33. Leenen, P. J., K. Radosevic, J. S. Voerman, B. Salomon, N. van Rooijen, D. Klatzmann, and W. van Ewijk. 1998. Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. J. Immunol. 160: 2166-2173.
34. Zhang, M., H. Tang, Z. Guo, H. An, X. Zhu, W. Song, J. Guo, X. Huang, T. Chen, J. Wang, and X. Cao. 2004. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5: 1124-1133.
35. Shortman, K., and L. Wu. 2004. Are dendritic cells end cells? Nat. Immunol. 5: 1105-1106.
36. Steinbrink, K., M. Wolfl, H. Jonuleit, J. Knop, and A. H. Enk. 1997. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 159: 4772-4780.
37. Dieu-Nosjean, M. C., C. Massacrier, B. Vanbervliet, W. H. Fridman, and C. Caux. 2001. IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-γ suppress it. J. Immunol. 167: 5594-5602.
38. Takayama, T., A. E. Morelli, N. Onai, M. Hirao, K. Matsushima, H. Tahara, and A. W. Thomson. 2001. Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability. J. Immunol. 166: 7136-7143.
39. Fortsch, D., M. Rollinghoff, and S. Stenger. 2000. IL-10 converts human dendritic cells into macrophage-like cells with increased antibacterial activity against virulent Mycobacterium tuberculosis. J. Immunol. 165: 978-987.
40. Nolan, K. F., V. Strong, D. Soler, P. J. Fairchild, S. P. Cobbold, R. Croxton, J. A. Gonzalo, A. Rubio, M. Wells, and H. Waldmann. 2004. IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals. J. Immunol. 172: 2201-2209.
41. + subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro. Eur. J. Immunol. 34: 2800-2811.
42. 1 integrin receptors. J. Leukocyte Biol. 51: 415-420.