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Volumn 12, Issue 1, 2013, Pages

Role of SIRT3 in the regulation of redox balance during oral carcinogenesis

Author keywords

Human oral keratinocyte; Oral squamous cell carcinoma; Reactive oxygen species; Sirtuin 3

Indexed keywords

CELL DNA; REACTIVE OXYGEN METABOLITE; SIRTUIN 3;

EID: 84879119336     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-68     Document Type: Article
Times cited : (28)

References (52)
  • 1
    • 29144494803 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers
    • Bsoul SA, Huber MA, Terezhalmy GT. Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J Contemp Dent Pract 2005, 6:1-16.
    • (2005) J Contemp Dent Pract , vol.6 , pp. 1-16
    • Bsoul, S.A.1    Huber, M.A.2    Terezhalmy, G.T.3
  • 2
  • 3
    • 0034955131 scopus 로고    scopus 로고
    • Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
    • 10.1016/S1368-8375(01)00003-3, 11435174
    • Jeng JH, Chang MC, Hahn LJ. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol 2001, 37:477-492. 10.1016/S1368-8375(01)00003-3, 11435174.
    • (2001) Oral Oncol , vol.37 , pp. 477-492
    • Jeng, J.H.1    Chang, M.C.2    Hahn, L.J.3
  • 4
    • 0141894080 scopus 로고    scopus 로고
    • Betel quid and areca nut are carcinogenic without tobacco
    • Sharma DC. Betel quid and areca nut are carcinogenic without tobacco. Lancet Oncol 2003, 4:587-587.
    • (2003) Lancet Oncol , vol.4 , pp. 587-587
    • Sharma, D.C.1
  • 5
    • 0030046535 scopus 로고    scopus 로고
    • Oxidative damage to DNA induced by areca nut extract
    • Liu TY, Chen CL, Chi CW. Oxidative damage to DNA induced by areca nut extract. Mutat Res-Genet Tox 1996, 367:25-31.
    • (1996) Mutat Res-Genet Tox , vol.367 , pp. 25-31
    • Liu, T.Y.1    Chen, C.L.2    Chi, C.W.3
  • 6
    • 0034806953 scopus 로고    scopus 로고
    • Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential
    • 10.1093/carcin/22.9.1527, 11532876
    • Chang MC, Ho YS, Lee PH, Chan CP, Lee JJ, Hahn LJ, Wang YJ, Jeng JH. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 2001, 22:1527-1535. 10.1093/carcin/22.9.1527, 11532876.
    • (2001) Carcinogenesis , vol.22 , pp. 1527-1535
    • Chang, M.C.1    Ho, Y.S.2    Lee, P.H.3    Chan, C.P.4    Lee, J.J.5    Hahn, L.J.6    Wang, Y.J.7    Jeng, J.H.8
  • 7
    • 0141426478 scopus 로고    scopus 로고
    • Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma-evidence for COX-2 induction by areca quid ingredients in oral keratinocytes
    • 10.1034/j.1600-0714.2003.00182.x, 12969226
    • Tang DW, Lin SC, Chang KW, Chi CW, Chang CS, Liu TY. Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma-evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. J Oral Pathol Med 2003, 32:522-529. 10.1034/j.1600-0714.2003.00182.x, 12969226.
    • (2003) J Oral Pathol Med , vol.32 , pp. 522-529
    • Tang, D.W.1    Lin, S.C.2    Chang, K.W.3    Chi, C.W.4    Chang, C.S.5    Liu, T.Y.6
  • 8
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • 10.1016/j.cell.2005.02.001, 15734681
    • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495. 10.1016/j.cell.2005.02.001, 15734681.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 9
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • 10.1016/j.cbi.2005.12.009, 16430879
    • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160:1-40. 10.1016/j.cbi.2005.12.009, 16430879.
    • (2006) Chem Biol Interact , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 10
    • 58149140055 scopus 로고    scopus 로고
    • Biological and potential therapeutic roles of sirtuin deacetylases
    • 10.1007/s00018-008-8357-y, 18820996
    • Taylor DM, Maxwell MM, Luthi-Carter R, Kazantsev AG. Biological and potential therapeutic roles of sirtuin deacetylases. Cell Mol Life Sci 2008, 65:4000-4018. 10.1007/s00018-008-8357-y, 18820996.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 4000-4018
    • Taylor, D.M.1    Maxwell, M.M.2    Luthi-Carter, R.3    Kazantsev, A.G.4
  • 11
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • 10.1038/35001622, 10693811
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000, 403:795-800. 10.1038/35001622, 10693811.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 12
    • 0037376665 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
    • 10.1016/S0955-0674(03)00006-1, 12648681
    • Lin SJ, Guarente L. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol 2003, 15:241-246. 10.1016/S0955-0674(03)00006-1, 12648681.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 241-246
    • Lin, S.J.1    Guarente, L.2
  • 13
    • 34547875773 scopus 로고    scopus 로고
    • Sirtuins: critical regulators at the crossroads between cancer and aging
    • 10.1038/sj.onc.1210616, 17694089
    • Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 2007, 26:5489-5504. 10.1038/sj.onc.1210616, 17694089.
    • (2007) Oncogene , vol.26 , pp. 5489-5504
    • Saunders, L.R.1    Verdin, E.2
  • 14
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • 10.1101/gad.1467506, 17079682
    • Haigis MC, Guarente LP. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006, 20:2913-2921. 10.1101/gad.1467506, 17079682.
    • (2006) Genes Dev , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 15
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: insights into their biological function
    • 10.1042/BJ20070140, 2753453, 17447894
    • Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J 2007, 404:1-13. 10.1042/BJ20070140, 2753453, 17447894.
    • (2007) Biochem J , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 16
    • 26244436281 scopus 로고    scopus 로고
    • Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
    • 10.1091/mbc.E05-01-0033, 1237069, 16079181
    • Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 2005, 16:4623-4635. 10.1091/mbc.E05-01-0033, 1237069, 16079181.
    • (2005) Mol Biol Cell , vol.16 , pp. 4623-4635
    • Michishita, E.1    Park, J.Y.2    Burneskis, J.M.3    Barrett, J.C.4    Horikawa, I.5
  • 17
    • 0037108799 scopus 로고    scopus 로고
    • SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
    • 10.1073/pnas.222538099, 129731, 12374852
    • Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci USA 2002, 99:13653-13658. 10.1073/pnas.222538099, 129731, 12374852.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13653-13658
    • Onyango, P.1    Celic, I.2    McCaffery, J.M.3    Boeke, J.D.4    Feinberg, A.P.5
  • 18
    • 0037135972 scopus 로고    scopus 로고
    • The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
    • 10.1083/jcb.200205057, 2174009, 12186850
    • Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 2002, 158:647-657. 10.1083/jcb.200205057, 2174009, 12186850.
    • (2002) J Cell Biol , vol.158 , pp. 647-657
    • Schwer, B.1    North, B.J.2    Frye, R.A.3    Ott, M.4    Verdin, E.5
  • 20
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • 10.1016/j.cmet.2010.11.015, 21109198
    • Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010, 12:662-667. 10.1016/j.cmet.2010.11.015, 21109198.
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 21
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • 10.1016/j.cell.2010.10.002, 3018849, 21094524
    • Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010, 143:802-812. 10.1016/j.cell.2010.10.002, 3018849, 21094524.
    • (2010) Cell , vol.143 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3    Xu, J.4    Vann, J.M.5    Leeuwenburgh, C.6    Tanokura, M.7    Denu, J.M.8    Prolla, T.A.9
  • 23
    • 78649509214 scopus 로고    scopus 로고
    • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
    • 10.1016/j.cmet.2010.11.003, 3310379, 21109197
    • Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, et al. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab 2010, 12:654-661. 10.1016/j.cmet.2010.11.003, 3310379, 21109197.
    • (2010) Cell Metab , vol.12 , pp. 654-661
    • Shimazu, T.1    Hirschey, M.D.2    Hua, L.3    Dittenhafer-Reed, K.E.4    Schwer, B.5    Lombard, D.B.6    Li, Y.7    Bunkenborg, J.8    Alt, F.W.9    Denu, J.M.10
  • 25
    • 78650248160 scopus 로고    scopus 로고
    • Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
    • 10.1016/j.molcel.2010.12.013, 3266626, 21172655
    • Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 2010, 40:893-904. 10.1016/j.molcel.2010.12.013, 3266626, 21172655.
    • (2010) Mol Cell , vol.40 , pp. 893-904
    • Tao, R.1    Coleman, M.C.2    Pennington, J.D.3    Ozden, O.4    Park, S.H.5    Jiang, H.6    Kim, H.S.7    Flynn, C.R.8    Hill, S.9    Hayes McDonald, W.10
  • 26
    • 79551584971 scopus 로고    scopus 로고
    • Regulation of intermediary metabolism by protein acetylation
    • 10.1016/j.tibs.2010.09.003, 3038179, 20934340
    • Guan KL, Xiong Y. Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci 2011, 36:108-116. 10.1016/j.tibs.2010.09.003, 3038179, 20934340.
    • (2011) Trends Biochem Sci , vol.36 , pp. 108-116
    • Guan, K.L.1    Xiong, Y.2
  • 27
  • 29
    • 79959819034 scopus 로고    scopus 로고
    • SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production
    • 10.1038/onc.2011.37, 3134877, 21358671
    • Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Oncogene 2011, 30:2986-2996. 10.1038/onc.2011.37, 3134877, 21358671.
    • (2011) Oncogene , vol.30 , pp. 2986-2996
    • Bell, E.L.1    Emerling, B.M.2    Ricoult, S.J.3    Guarente, L.4
  • 30
    • 80052291180 scopus 로고    scopus 로고
    • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
    • 10.1073/pnas.1111308108, 3167496, 21873205
    • Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci USA 2011, 108:14608-14613. 10.1073/pnas.1111308108, 3167496, 21873205.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14608-14613
    • Jing, E.1    Emanuelli, B.2    Hirschey, M.D.3    Boucher, J.4    Lee, K.Y.5    Lombard, D.6    Verdin, E.M.7    Kahn, C.R.8
  • 31
    • 70349208608 scopus 로고    scopus 로고
    • Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
    • 2735933, 19652361
    • Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest 2009, 119:2758-2771. 2735933, 19652361.
    • (2009) J Clin Invest , vol.119 , pp. 2758-2771
    • Sundaresan, N.R.1    Gupta, M.2    Kim, G.3    Rajamohan, S.B.4    Isbatan, A.5    Gupta, M.P.6
  • 32
    • 82455212901 scopus 로고    scopus 로고
    • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
    • 10.1016/j.molcel.2011.07.019, 3563434, 21856199
    • Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancakova A, Goetzman E, Lam MM, Schwer B, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011, 44:177-190. 10.1016/j.molcel.2011.07.019, 3563434, 21856199.
    • (2011) Mol Cell , vol.44 , pp. 177-190
    • Hirschey, M.D.1    Shimazu, T.2    Jing, E.3    Grueter, C.A.4    Collins, A.M.5    Aouizerat, B.6    Stancakova, A.7    Goetzman, E.8    Lam, M.M.9    Schwer, B.10
  • 33
    • 77955347446 scopus 로고    scopus 로고
    • Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
    • 10.1371/journal.pone.0011707, 2908542, 20661474
    • Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y. Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One 2010, 5:e11707. 10.1371/journal.pone.0011707, 2908542, 20661474.
    • (2010) PLoS One , vol.5
    • Kong, X.1    Wang, R.2    Xue, Y.3    Liu, X.4    Zhang, H.5    Chen, Y.6    Fang, F.7    Chang, Y.8
  • 34
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • 10.1006/bbrc.2000.3000, 10873683
    • Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 2000, 273:793-798. 10.1006/bbrc.2000.3000, 10873683.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 793-798
    • Frye, R.A.1
  • 35
    • 38149007268 scopus 로고    scopus 로고
    • Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy
    • 10.1177/154405910808700104, 18096889
    • Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 2008, 87:14-32. 10.1177/154405910808700104, 18096889.
    • (2008) J Dent Res , vol.87 , pp. 14-32
    • Choi, S.1    Myers, J.N.2
  • 38
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • 10.1038/nature08197, 19641587
    • Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009, 460:587-591. 10.1038/nature08197, 19641587.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 39
    • 79955768567 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype
    • 10.1074/jbc.M110.202390, 3089539, 21454513
    • Giralt A, Hondares E, Villena JA, Ribas F, Diaz-Delfin J, Giralt M, Iglesias R, Villarroya F. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem 2011, 286:16958-16966. 10.1074/jbc.M110.202390, 3089539, 21454513.
    • (2011) J Biol Chem , vol.286 , pp. 16958-16966
    • Giralt, A.1    Hondares, E.2    Villena, J.A.3    Ribas, F.4    Diaz-Delfin, J.5    Giralt, M.6    Iglesias, R.7    Villarroya, F.8
  • 40
    • 17144424946 scopus 로고    scopus 로고
    • SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    • 10.1074/jbc.M414670200, 15653680
    • Shi T, Wang F, Stieren E, Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 2005, 280:13560-13567. 10.1074/jbc.M414670200, 15653680.
    • (2005) J Biol Chem , vol.280 , pp. 13560-13567
    • Shi, T.1    Wang, F.2    Stieren, E.3    Tong, Q.4
  • 41
    • 50149103440 scopus 로고    scopus 로고
    • Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
    • 10.1016/j.jmb.2008.07.048, 18680753
    • Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol 2008, 382:790-801. 10.1016/j.jmb.2008.07.048, 18680753.
    • (2008) J Mol Biol , vol.382 , pp. 790-801
    • Schlicker, C.1    Gertz, M.2    Papatheodorou, P.3    Kachholz, B.4    Becker, C.F.5    Steegborn, C.6
  • 43
    • 10744232772 scopus 로고    scopus 로고
    • Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
    • 10.1016/S0531-5565(03)00209-2, 14580859
    • Rose G, Dato S, Altomare K, Bellizzi D, Garasto S, Greco V, Passarino G, Feraco E, Mari V, Barbi C, et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol 2003, 38:1065-1070. 10.1016/S0531-5565(03)00209-2, 14580859.
    • (2003) Exp Gerontol , vol.38 , pp. 1065-1070
    • Rose, G.1    Dato, S.2    Altomare, K.3    Bellizzi, D.4    Garasto, S.5    Greco, V.6    Passarino, G.7    Feraco, E.8    Mari, V.9    Barbi, C.10
  • 44
    • 19944433088 scopus 로고    scopus 로고
    • A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    • 10.1016/j.ygeno.2004.11.003, 15676284
    • Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, Greco V, Maggiolini M, Feraco E, Mari V, et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 2005, 85:258-263. 10.1016/j.ygeno.2004.11.003, 15676284.
    • (2005) Genomics , vol.85 , pp. 258-263
    • Bellizzi, D.1    Rose, G.2    Cavalcante, P.3    Covello, G.4    Dato, S.5    De Rango, F.6    Greco, V.7    Maggiolini, M.8    Feraco, E.9    Mari, V.10
  • 45
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • 10.1038/ng.685, 3000924,3000924, 20935629
    • Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Magi R, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010, 42:949-960. 10.1038/ng.685, 3000924,3000924, 20935629.
    • (2010) Nat Genet , vol.42 , pp. 949-960
    • Heid, I.M.1    Jackson, A.U.2    Randall, J.C.3    Winkler, T.W.4    Qi, L.5    Steinthorsdottir, V.6    Thorleifsson, G.7    Zillikens, M.C.8    Speliotes, E.K.9    Magi, R.10
  • 49
    • 62649152321 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in Two different cell lines Via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction
    • 10.1002/jcb.22044, 19160423
    • Marfe G, Tafani M, Indelicato M, Sinibaldi-Salimei P, Reali V, Pucci B, Fini M, Russo MA. Kaempferol induces apoptosis in Two different cell lines Via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. J Cell Biochem 2009, 106:643-650. 10.1002/jcb.22044, 19160423.
    • (2009) J Cell Biochem , vol.106 , pp. 643-650
    • Marfe, G.1    Tafani, M.2    Indelicato, M.3    Sinibaldi-Salimei, P.4    Reali, V.5    Pucci, B.6    Fini, M.7    Russo, M.A.8
  • 50
    • 36849002444 scopus 로고    scopus 로고
    • SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways
    • 10.4161/cc.6.21.4866, 17957139
    • Allison SJ, Milner J. SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways. Cell Cycle 2007, 6:2669-2677. 10.4161/cc.6.21.4866, 17957139.
    • (2007) Cell Cycle , vol.6 , pp. 2669-2677
    • Allison, S.J.1    Milner, J.2
  • 51
    • 74049115560 scopus 로고    scopus 로고
    • A tumor suppressor SIRTainty
    • 10.1016/j.ccr.2009.12.032, 20129243
    • Schumacker PT. A tumor suppressor SIRTainty. Cancer Cell 2010, 17:5-6. 10.1016/j.ccr.2009.12.032, 20129243.
    • (2010) Cancer Cell , vol.17 , pp. 5-6
    • Schumacker, P.T.1
  • 52
    • 33747893489 scopus 로고    scopus 로고
    • Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability
    • 10.1158/0008-5472.CAN-06-0833, 16885361
    • Slane BG, Aykin-Burns N, Smith BJ, Kalen AL, Goswami PC, Domann FE, Spitz DR. Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res 2006, 66:7615-7620. 10.1158/0008-5472.CAN-06-0833, 16885361.
    • (2006) Cancer Res , vol.66 , pp. 7615-7620
    • Slane, B.G.1    Aykin-Burns, N.2    Smith, B.J.3    Kalen, A.L.4    Goswami, P.C.5    Domann, F.E.6    Spitz, D.R.7


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