Effects of 47C allele (rs4880) of the SOD2 gene in the production of intracellular reactive species in peripheral blood mononuclear cells with and without lipopolysaccharides induction

Free Radical Research

Volumn 48, Issue 2, 2014, Pages 190-199

  Paludo, F J O ^a   Bristot, I J ^a   Alho, C S ^b   Gelain, D P ^a   Moreira, J C F ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Lipopolysaccharides; Peripheral blood mononuclear cells; Reactive species; Sepsis; SOD2 Ala 9Val polymorphism

Indexed keywords

CELL ENZYME; DICHLOROFLUORESCEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

ADULT; ALLELE; ARTICLE; ASSAY; CELL ISOLATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; WESTERN BLOTTING;

ADULT; CELLS, CULTURED; DNA DAMAGE; GENETIC ASSOCIATION STUDIES; HUMANS; KINETICS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MITOCHONDRIA; NITRITES; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE; YOUNG ADULT;

EID: 84890054480     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2013.859385     Document Type: Article

References (54)

1. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655.
2. Dahmer MK, Randolph A, Vitali S, Quasney MW. Genetic polymorphisms in sepsis. Pediatr Crit Care Med 2005; 6: S61-S73.
3. Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420: 885-891.
4. Russell JA. Management of sepsis. N Engl J Med 2006; 355: 1699-1713.
5. L ó pez-Boj ó rquez LN, Dehesa AZ, Reyes-Ter á n G. Molecular mechanisms involved in the pathogenesis of septic shock. Arch Med Res 2004; 35: 465-479.
6. B ö hrer H, Qiu F, B in the Zimmermann T, Zhang Y, Jllmer T, M ä nnel D, et al. Role of NF Mortality of Sepsis. J Clin Invest 1997; 100: 972-985.
7. McDonald PP, Bald A, Cassatella MA. Activation of the NF-kB pathway by infl ammatory stimuli in human neutrophils. Blood 1997; 89: 3421-3433.
8. Hatada EN, Krappmann D, Scheidereit C. NF-kB and the innate immune response. Curr Opin Immunol 2000; 12: 52-58.
9. Zingarelli B. Nuclear factor-kappaB. Crit Care Med 2005; 33: S414-S416.
10. Dr ö ge W. Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47-95.
11. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000; 279: 1005-1028.
12. Victor VM, Rocha M, De la Fuente M. Immune cells: Free radicals and antioxidants in sepsis. Int Immunopharmacol 2004; 4: 327-347.
13. Adler V, Yin Z, Tew KD, Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 1999; 18: 6104-6111.
14. Callahan LA, Supinski GS. Sepsis induces diaphragm electron transport chain dysfunction and protein depletion. Am J Respir Crit Care Med 2005; 172: 861-868.
15. Williams MD, Van Remmen H, Conrad CC, Huang TT, Epstein CJ, Richardson A. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J Biol Chem 1998; 273: 28510-28515.
16. Weisiger RA, Fridovich I. Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J Biol Chem 1973; 248: 4793-4796.
17. Wisp é JR, Clark JC, Burhans MS, Kropp KE, Korfhagen TR, Whitsett JA. Synthesis and processing of the precursor for human mangano-superoxide dismutase. Biochim Biophys Acta 1989; 994: 30-36.
18. Beck Y, Oren R, Amit B, Levanon A, Gorecki M, Hartman Jr. Human Mn superoxide dismutase cDNA sequence. Nucleic Acids Res 1987; 15: 9076.
19. Ho YS, Crapo JD. Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase. FEBS Lett 1988; 229: 256-260.
20. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1995; 11: 376-381.
21. Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, et al. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutasedeficient mice. Proc Natl Acad Sci USA 1996; 93: 9782-9787.
22. Van Remmen H, Salvador C, Yang H, Huang TT, Epstein CJ, Richardson A. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch Biochem Biophys 1999; 363: 91-97.
23. Church SL, Grant JW, Meese EU, Trent JM. Sublocalization of the gene encoding manganese superoxide dismutase (MnSOD/SOD2) to 6q25 by fl uorescence in situ hybridization and somatic cell hybrid mapping. Genomics 1992; 14: 823-825.
24. Wan XS, Devalaraja MN, St Clair DK. Molecular structure and organization of the human manganese superoxide dismutase gene. DNA Cell Biol 1994; 13: 1127-1136.
25. Rosenblum JS, Gilula NB, Lerner RA. On signal sequence polymorphisms and diseases of distribution. Proc Natl Acad Sci USA 1996; 93: 4471-4473.
26. Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y. Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to infl uence mitochondrial transport and a study of allelic association in Parkinson's disease. Biochem Biophys Res Commun 1996; 226: 561-565.
27. Shimoda-Matsubayashi S, Hattori T, Matsumine H, Shinohara A, Yoritaka A, Mori H, et al. MnSOD activity and protein in a patient with chromosome 6-linked autosomal recessive parkinsonism in comparison with Parkinson's disease and control. Am Acad Neurol 1997; 49: 1257-1262.
28. Hiroi S, Harada H, Nishi H, Satoh M, Nagai R, Kimura A. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Biochem Biophys Res Commun 1999; 261: 332-339.
29. Sutton A, Imbert A, Igoudjil A, Descatoire V, Cazanave S, Pessayre D, Degoul F. The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability. Pharmacogenet Genom 2005; 15: 311-319.
30. Paludo FJO, Sim õ es-Pires A, Alho CS, Gelain DP, Moreira JC. Participation of 47C - T SNP (Ala-9Val polymorphism) of the SOD2 gene in the intracellular environment of human peripheral blood mononuclear cells with and without lipopolysaccharides. Mol Cell Biochem 2013; 372: 127-135.
31. Salzano FM, Freire-Maia N. 1970. Problems in human biology: A study of Brazilian populations. Detroit: Wayne State University Press.
32. Parra FC, Amado RC, Lambertucci JR, Rocha J, Antunes CM, Pena SD. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci USA 2003; 100: 177-182.
33. Borgstahl GE, Parge HE, Hickey MJ, Johnson MJ, Boissinot M, Hallewell RA, et al. Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. Biochemistry 1996; 35: 4287-4297.
34. Zhang HJ, Yan T, Oberley TD, Oberley LW. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res 1999; 59: 6276-6283.
35. Nunes FB, Graziottin CM, Alves-Filho JCF, Lunardelli A, Caberlon E, Peres A, Oliveira Jr. Immunomodulatory effect of fructose-1, 6-bisphosphate on T-lymphocytes. Int Immunopharmacol 2003; 3: 267-272.
36. Lahiri DK, Nurnberger JI Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 1991; 19: 5444.
37. Taufer M, Peres A, de Andrade VM, de Oliveira G, S á G, do Canto ME, et al. Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process? J Gerontol A Biol Sci Med Sci 2005; 60: 432-438.
38. Cai Q, Shu XO, Wen W, Cheng JR, Dai Q, Gao YT, Zheng W. Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: Results from the Shanghai Breast Cancer Study. Breast Cancer Res 2004; 6: R647-R655.
39. Green R, Wagner D, Glagowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and (15 N) nitrate in biological fl uids. Anal Biochem 1982; 126: 131-138.
40. Robinson JP, Bruner LH, Bassoe CF, Hudson JL, Ward PA, Phan SH. Measurement of intracellular fl uorescence of human monocytes relative to oxidative metabolism. J Leukoc Biol 1988; 43: 304-310.
41. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-191.
42. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
43. Martins PS, Kallas EG, Neto MC, Dalboni MA, Blecher S, Salomão R. Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock. Shock 2003; 20: 208-212.
44. Martins PS, Brunialti MK, Martos LS, Machado FR, Assun ç ao MS, Blecher S, Salomao R. Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis. Crit Care 2008; 12: R25.
45. Santos SS, Brunialti MK, Rigato O, Machado FR, Silva E, Salomao R. Generation of nitric oxide and reactive oxygen species by neutrophils and monocytes from septic patients and association with outcomes. Shock 2012; 38: 18-23.
46. Na HK, Oliynyk S. Effects of physical activity on cancer prevention. Ann NY Acad Sci 2011; 1229: 176-183.
47. Paludo FJ, Pican ç o JB, Fallavena PR, Fraga LR, Graebin P, N óbrega OT, et al. Higher frequency of septic shock in septic patients with the 47C allele (rs4880) of the SOD2 gene. Gene 2013; 517: 106-111.
48. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol 1996; 271: C1424-C1437.
49. Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 1992; 298: 431-437.
50. Kong SK, Yim MB, Stadtman ER, Chock PB. Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide. Proc Natl Acad Sci USA 1996; 93: 3377-3382.
51. Wang S, Wang F, Shi X, Dai J, Peng Y, Guo X, et al. Association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer risk-A meta-Analysis. Eur J Cancer 2009; 45: 2874-2881.
52. Van Landeghem GF, Tabatabaie P, Beckman G, Beckman L, Andersen PM. Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease. Eur J Neurol 1999; 6: 639-644.
53. Akyol O, Yanik M, Elyas H, Namli M, Canatan H, Akin H, et al. Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 123-131.
54. Kimura K, Isashiki Y, Sonoda S, Kakiuchi-Matsumoto T, Ohba N. Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration. Am J Ophthalmol 2000; 130: 769-773.