Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Archives of Toxicology

Volumn 89, Issue 7, 2015, Pages 1103-1117

  Lee, Wei Jiunn ^a   Hsiao, Michael ^b   Chang, Junn Liang ^c,d   Yang, Shun Fa ^e,f   Tseng, Tsui Hwa ^e   Cheng, Chao Wen ^g   Chow, Jyh Ming ^a   Lin, Ke Hsun ^a   Lin, Yung Wei ^a   Liu, Chung Chi ^a   Lee, Liang Ming ^a   Chien, Ming Hsien ^a,g  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c TAOYUAN ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^d MING CHUAN UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^f CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Acute myeloid leukemia; Apoptosis; Extracellular signal regulated kinase; Quercetin; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXIDE; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; QUERCETIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; OXIDIZING AGENT; PROTEIN KINASE INHIBITOR;

A549 CELL LINE; ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FLOW CYTOMETRY; HL 60 CELL LINE; HUMAN; HUMAN CELL; HYDROLYSIS; IC50; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LIVER CELL CARCINOMA; LUNG CANCER; LUNG FIBROBLAST; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MOUSE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR VOLUME; TUMOR XENOGRAFT; U937 CELL LINE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NUDE MOUSE; PATHOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; TIME FACTOR;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, NUDE; MICE, SCID; MITOCHONDRIA; OXIDANTS; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; QUERCETIN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84930932525     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1300-0     Document Type: Article

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