Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death

Archives of Toxicology

Volumn 89, Issue 7, 2015, Pages 1057-1070

  Gong, Xuezhong ^a,c   Ivanov, Vladimir N ^a   Davidson, Mercy M ^b   Hei, Tom K ^a,b  

^a Columbia University ^*  (United States)

^b Shanghai University of Traditional Chinese Medicine ^*  (United States)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Autophagy; Cyclooxygenase 2; Mitochondrial dysfunction; Nephrotoxicity; Sodium arsenite; Tetramethylpyrazine (TMP)

Indexed keywords

ACETYLCYSTEINE; ARSENITE SODIUM; BETA CATENIN; CYCLOOXYGENASE 2; CYTOCHROME C OXIDASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; TETRAMETHYLPYRAZINE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; ARSENOUS ACID DERIVATIVE; AUTACOID; BIOLOGICAL MARKER; PYRAZINE DERIVATIVE; SODIUM DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; EPITHELIUM CELL; HISTOCHEMISTRY; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL PROTECTION; SIGNAL TRANSDUCTION; UPREGULATION; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; KIDNEY DISEASE; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; TIME FACTOR;

ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENITES; AUTOPHAGY; BIOMARKERS; CELL LINE; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMANS; INFLAMMATION MEDIATORS; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; PYRAZINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SODIUM COMPOUNDS; TIME FACTORS;

EID: 84930928547     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1302-y     Document Type: Article

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