Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption

Toxicology and Applied Pharmacology

Volumn 272, Issue 3, 2013, Pages 879-887

  Srivastava, Ritesh K ^a   Li, Changzhao ^a   Chaudhary, Sandeep C ^a   Ballestas, Mary E ^b   Elmets, Craig A ^a   Robbins, David J ^c   Matalon, Sadis ^d   Deshane, Jessy S ^e   Afaq, Farrukh ^a   Bickers, David R ^f   Athar, Mohammad ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e and Clinical Center   (United States)

^f New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

Innate immune function; Inorganic arsenic; Macrophage; PBA; ROS; UPR

Indexed keywords

4 PHENYLBUTYRIC ACID; ACETYLCYSTEINE; ARSENIC TRIOXIDE; INTERLEUKIN 10; INTERLEUKIN 1BETA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CELL PROTECTION; CYTOKINE PRODUCTION; IMMUNE DEFICIENCY; INNATE IMMUNITY; INTERNALIZATION; LONG TERM EXPOSURE; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; REGULATORY MECHANISM; UNFOLDED PROTEIN RESPONSE;

INNATE IMMUNE FUNCTION; INORGANIC ARSENIC; MACROPHAGE; PBA; ROS; UPR;

ANIMALS; ARSENICALS; CELL LINE; IMMUNITY, INNATE; MACROPHAGES; MICE; OXIDES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 84884729409     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.08.004     Document Type: Article

References (47)

1. Abhyankar L.N., Jones M.R., Guallar E., Navas-Acien A. Arsenic exposure and hypertension: a systematic review. Environ. Health Perspect. 2012, 120:494-500.
2. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
3. Aranyi C., Bradof J.N., O'Shea W.J., Graham J.A., Miller F.J. Effects of arsenic trioxide inhalation exposure on pulmonary antibacterial defenses in mice. J. Toxicol. Environ. Health 1985, 15:163-172.
4. Beauchamp E.M., Uren A. A new era for an ancient drug: arsenic trioxide and Hedgehog signaling. Vitam. Horm. 2012, 88:333-354.
5. Benbrahim-Tallaa L., Waalkes M.P. Inorganic arsenic and human prostate cancer. Environ. Health Perspect. 2008, 116:158-164.
6. Binet F., Chiasson S., Girard D. Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils. Int. Immunopharmacol. 2010, 10:508-512.
7. Bomberger J.M., Coutermarsh B.A., Barnaby R.L., Stanton B.A. Arsenic promotes ubiquitination and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells. J. Biol. Chem. 2012, 287:17130-17139.
8. Brown K.G., Ross G.L., American Council on Science and Health Arsenic, drinking water, and health: a position paper of the American Council on Science and Health. Regul. Toxicol. Pharmacol. 2002, 36:162-174.
9. Burchiel S.W., Mitchell L.A., Lauer F.T., Sun X., McDonald J.D., Hudson L.G., Liu K.J. Immunotoxicity and biodistribution analysis of arsenic trioxide in C57Bl/6 mice following a 2-week inhalation exposure. Toxicol. Appl. Pharmacol. 2009, 241:253-259.
10. Cnop M., Foufelle F., Velloso L.A. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol. Med. 2012, 18:59-68.
11. Gibb H., Haver C., Gaylor D., Ramasamy S., Lee J.S., Lobdell D., Wade T., Chen C., White P., Sams R. Utility of recent studies to assess the National Research Council 2001 estimates of cancer risk from ingested arsenic. Environ. Health Perspect. 2011, 119:284-290.
12. Hughes M.F., Beck B.D., Chen Y., Lewis A.S., Thomas D.J. Arsenic exposure and toxicology: a historical perspective. Toxicol. Sci. 2011, 123:305-332.
13. Kozul C.D., Ely K.H., Enelow R.I., Hamilton J.W. Low-dose arsenic compromises the immune response to influenza A infection in vivo. Environ. Health Perspect. 2009, 117:1441-1447.
14. Kozul C.D., Hampton T.H., Davey J.C., Gosse J.A., Nomikos A.P., Eisenhauer P.L., Weiss D.J., Thorpe J.E., Ihnat M.A., Hamilton J.W. Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ. Health Perspect. 2009, 117:1108-1115.
15. Lemarie A., Morzadec C., Bourdonnay E., Fardel O., Vernhet L. Human macrophages constitute targets for immunotoxic inorganic arsenic. J. Immunol. 2006, 177:3019-3027.
16. Lemarie A., Morzadec C., Merino D., Micheau O., Fardel O., Vernhet L. Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. J. Pharmacol. Exp. Ther. 2006, 316:304-314.
17. Li C., Xu J., Li F., Chaudhary S.C., Weng Z., Wen J., Elmets C.A., Ahsan H., Athar M. Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenic-induced cutaneous inflammation. Cancer Prev. Res. 2011, 4:2101-2109.
18. Li L.Z., Deng H.X., Lou W.Z., Sun X.Y., Song M.W., Tao J., Xiao B.X., Guo J.M. Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest. World J. Gastroenterol. 2012, 18:79-83.
19. Li X., Xu C., Yang P. c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes 2013, 62:599-608.
20. Liu J., Ren F., Cheng Q., Bai L., Shen X., Gao F., Busuttil R.W., Kupiec-Weglinski J.W., Zhai Y. Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. Transplantation 2012, 94:211-217.
21. Liu C.M., Zheng G.H., Ming Q.L., Sun J.M., Cheng C. Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. Free Radic. Res. 2013, 47:192-201.
22. Lu T.H., Su C.C., Chen Y.W., Yang C.Y., Wu C.C., Hung D.Z., Chen C.H., Cheng P.W., Liu S.H., Huang C.F. Arsenic induces pancreatic beta-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicol. Lett. 2011, 201:15-26.
23. Martin-Chouly C., Morzadec C., Bonvalet M., Galibert M.D., Fardel O., Vernhet L. Inorganic arsenic alters expression of immune and stress response genes in activated primary human T lymphocytes. Mol. Immunol. 2011, 48:956-965.
24. Mazumder D.N., Haque R., Ghosh N., De B.K., Santra A., Chakraborti D., Smith A.H. Arsenic in drinking water and the prevalence of respiratory effects in West Bengal, India. Int. J. Epidemiol. 2000, 29:1047-1052.
25. Mink P.J., Alexander D.D., Barraj L.M., Kelsh M.A., Tsuji J.S. Low-level arsenic exposure in drinking water and bladder cancer: a review and meta-analysis. Regul. Toxicol. Pharmacol. 2008, 52:299-310.
26. Nayak A.S., Lage C.R., Kim C.H. Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio). Toxicol. Sci. 2007, 98:118-124.
27. Nouri K., Ricotti C.A., Bouzari N., Chen H., Ahn E., Bach A. The incidence of recurrent herpes simplex and herpes zoster infection during treatment with arsenic trioxide. J. Drugs Dermatol. 2006, 5:182-185.
28. Oh R.S., Pan W.C., Yalcin A., Zhang H., Guilarte T.R., Hotamisligil G.S., Christiani D.C., Lu Q. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J. Biol. Chem. 2012, 287:6025-6034.
29. Parvez F., Chen Y., Brandt-Rauf P.W., Slavkovich V., Islam T., Ahmed A., Argos M., Hassan R., Yunus M., Haque S.E., Balac O., Graziano J.H., Ahsan H. A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS). Thorax 2010, 65:528-533.
30. Patterson R., Vega L., Trouba K., Bortner C., Germolec D. Arsenic-induced alterations in the contact hypersensitivity response in Balb/c mice. Toxicol. Appl. Pharmacol. 2004, 198:434-443.
31. Pion M., Stalder R., Correa R., Mangeat B., Towers G.J., Piguet V. Identification of an arsenic-sensitive block to primate lentiviral infection of human dendritic cells. J. Virol. 2007, 81:12086-12090.
32. Qi J., Qiao Y., Wang P., Li S., Zhao W., Gao C. microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-kappaB1 in murine macrophages. FEBS Lett. 2012, 586:1201-1207.
33. Rahman A., Vahter M., Ekstrom E.C., Persson L.A. Arsenic exposure in pregnancy increases the risk of lower respiratory tract infection and diarrhea during infancy in Bangladesh. Environ. Health Perspect. 2011, 119:719-724.
34. Raqib R., Ahmed S., Sultana R., Wagatsuma Y., Mondal D., Hoque A.M., Nermell B., Yunus M., Roy S., Persson L.A., Arifeen S.E., Moore S., Vahter M. Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh. Toxicol. Lett. 2009, 185:197-202.
35. Sakurai T., Ohta T., Fujiwara K. Inorganic arsenite alters macrophage generation from human peripheral blood monocytes. Toxicol. Appl. Parmacol. 2005, 203:145-153.
36. Sarantis H., Grinstein S. Subversion of phagocytosis for pathogen survival. Cell Host Microbe 2012, 12:419-431.
37. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997, 89:3354-3360.
38. Smith A.H., Marshall G., Yuan Y., Liaw J., Ferreccio C., Steinmaus C. Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis. Am. J. Epidemiol. 2011, 173:414-420.
39. Srivastava R., Rahman Q., Kashyap M., Singh A., Jain G., Jahan S., Lohani M., Lantow M., Pant A. Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549. Hum. Exp. Txicol. 2013, 32:153-156.
40. Wang S., Kaufman R.J. The impact of the unfolded protein response on human disease. J. Cell Biol. 2012, 197:857-867.
41. Wang J.Q., Chen X., Zhang C., Tao L., Zhang Z.H., Liu X.Q., Xu Y.B., Wang H., Li J., Xu D.X. Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice. Toxicol. Appl. Pharmacol. 2012, 266:307-316.
42. Wiley J.C., Pettan-Brewer C., Ladiges W.C. Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice. Aging Cell 2011, 10:418-428.
43. Wiseman R.L., Haynes C.M., Ron D. SnapShot: the unfolded protein response. Cell 2010, 140:590-590.
44. Yen Y.P., Tsai K.S., Chen Y.W., Huang C.F., Yang R.S., Liu S.H. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Arch. Toxicol. 2012, 86:923-933.
45. Zhang K. Integration of ER stress, oxidative stress and the inflammatory response in health and disease. Int. J. Clin. Exp. Med. 2010, 3:33-40.
46. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
47. Zhou L.F., Zhu Y., Cui X.F., Xie W.P., Hu A.H., Yin K.S. Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyper responsiveness and inflammation. Respir. Res. 2006, 7:146.