Syntheses and evaluation of asymmetric curcumin analogues as potential multifunctional agents for the treatment of Alzheimer’s disease

Current Alzheimer Research

Volumn 12, Issue 5, 2015, Pages 403-414

  Zhai, Peng ^a   Xia, Chun Li ^a   Tan, Jia Heng ^a   Li, Ding ^a   Ou, Tian Miao ^a   Huang, Shi Liang ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Amyloid beta aggregation; Anti Alzheimer s agent; Curcumin analogues; Metal chelation; Multifunctional inhibitor

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CLIOQUINOL; COPPER ION; CURCUMIN; CURCUMIN DERIVATIVE; IRON; TROLOX C; UNCLASSIFIED DRUG; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ANTIOXIDANT; CHELATING AGENT; CHROMAN DERIVATIVE; COPPER; NEUROPROTECTIVE AGENT; OXYGEN; PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CHELATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ORAC ASSAY; PRIORITY JOURNAL; PROTEIN AGGREGATION; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; SPECTROSCOPY; SYNTHESIS; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; CELL LINE, TUMOR; CHELATING AGENTS; CHROMANS; COPPER; CURCUMIN; DRUG EVALUATION; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; OXYGEN; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84930893442     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205012666150504151120     Document Type: Article

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