Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 71-83

  Kim, Young Seub ^a,b   Jung, Sun Hwa ^a,c   Park, Beoung Geon ^a,c   Ko, Min Kyung ^a   Jang, Hyun Seo ^a   Choi, Kihang ^c   Baik, Ja Hyun ^c   Lee, Jiyoun ^d   Lee, Jae Kyun ^a   Pae, Ae Nim ^a,b   Cho, Yong Seo ^a,b   Min, Sun Joon ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Korea University   (South Korea)

^d Sungshin Women's University   (South Korea)

Author keywords

Alzheimer's disease; Amyloid beta; Mitochondrial permeability transition pore (mPTP); Oxime derivatives; Pharmacokinetics

Indexed keywords

2 (3,4 DICHLOROBENZYL)OXYBENZALDEHYDE O (1 BENZYLPYRROLIDIN 3 YL) OXIME; AMYLOID BETA PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; OXIME DERIVATIVE; PIRACETAM; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN TISSUE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG HALF LIFE; DRUG PENETRATION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MALE; MICROSOME; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; HUMANS; MALE; MICE; MICE, INBRED ICR; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MOLECULAR STRUCTURE; OXIMES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84872676241     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.033     Document Type: Article

References (23)

1. W.W. Pendleburya, and P.R. Solomoni Neurobiol. Aging 15 1994 287 289
2. M.R. Roberson, and L.E. Harrell Brain Res. Rev. 25 1997 50 69
3. P.H. Reddy Exper. Neuro 218 2009 286 292
4. W. Cerpa, M.C. Dinamarca, and N.C. Inestrosa Curr. Alzheimer Res. 5 2008 233 243
5. H. Du, and S.S. Yan Biochim. Biophys. Acta 1802 2010 198 204
6. P. Bernardi Physiol. Rev. 79 1999 1127 1155
7. A.A. Starkov, and F.M. Beal Nat. Med. 14 2008 1020 1021
8. M. Zoratti, and I. Szabo Biochim. Biophys. Acta 1241 1995 139 176
9. A.W. Leung, and A.P. Halestrap Biochim. Biophys. Acta 1777 2008 946 952
10. H. Du, L. Guo, F. Fang, D. Chen, A.A. Sosunov, G.M. McKhann, Y. Yan, C. Wang, H. Zhang, J.D. Molkentin, F.J. Gunn-Moore, J.P. Vonsattel, O.A. John, X. Chen, and S.D. Yan Nat. Med. 14 2008 1097 1105
11. C. Chinopoulos, A.A. Starkov, and G. Fiskum J. Biol. Chem. 278 2003 27382 27389
12. Z. Zhonga, T.P. Theruvath, R.T. Currin, P.C. Waldmeier, and J.J. Lemastersa Am. J. Transplant. 7 2007 1103 1111
13. S. Bachurin, F. Bukatina, N. Lermontova, S. Tkachenko, A. Afanasiev, V. Grigoriev, I. Grigorieva, Y. Ivanov, S. Sablin, and N. Zefirov Ann. N. Y. Acad. Sci. 939 2001 425 435
14. S. Zhang, L. Hedskog, C.A. Petersen, B. Winblad, and M. Ankarcrona J. Alzheimer's Dis. 21 2010 389 402
15. S.H. Eckert, J. Eckmann, K. Renner, G.P. Eckert, K. Leuner, and W.E. Muller J. Alzheimer's Dis. 31 2012 21 32
16. B.K. Wagner, T. Kitami, T.J. Gilbert, D. Peck, A. Ramanathan, S.L. Schreiber, T.R. Golub, and V.K. Mootha Nat. Biotech. 26 2008 343 351
17. S.T. Smiley, M.Reers, C. Mottola-Hartshorn, M. Lin, A. Chen, T.W. Smith, G.D. Steele Jr., and L.B. Chen Proc. Natl. Acad. Sci. U. S. A. 88 1991 3671 3675
18. K. Tani, and B.M. Stoltz Nature 441 2006 731 734
19. C. Kurz, I. Ungerer, U. Lipka, S. Kirr, T. Schütt, A. Eckert, K. Leuner, and W.E. Müller Br. J. Pharm. 160 2010 246 257
20. S.P. Crouch, R. Kozlowski, K.J. Slater, and J. Fletcher J. Immunol. Methods 160 1993 81 88
21. M.V. Berridge, and A.S. Tan Arch. Biochem. Biophys. 303 1993 474 482
22. G. Ye, N.S. Metreveli, J. Ren, and P.N. Epstein Diabetes 52 2003 777 783
23. M. Gibaldi, and D. Perrier Pharmacokinetics second ed. 1982 Marcel-Dekker New York