STAT3 inhibitor stattic enhances radiosensitivity in esophageal squamous cell carcinoma

Tumor Biology

Volumn 36, Issue 3, 2015, Pages 2135-2142

  Zhang, Qu ^a,b   Zhang, Chi ^c   He, Jia ^d   Guo, Qing ^e   Hu, Desheng ^a   Yang, Xi ^c   Wang, Jinfeng ^b   Kang, Yahui ^b   She, Ruifang ^b   Wang, Zhongming ^b   Li, Defan ^b   Huang, Guanhong ^b   Ma, Zhaoming ^b   Mao, Weidong ^d   Zhou, Xiaoyi ^a   Xiao, Chuangying ^a   Sun, Xinchen ^c   Ma, Jianxin ^b  

^a HUBEI CANCER HOSPITAL   (China)

^b Lianyungang Hospital Affiliated to Bengbu Medical College   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d JIANGYIN PEOPLE S HOSPITAL   (China)

^e People's Hospital of Taizhou   (China)

Author keywords

ESCC; Radiosensitivity; STAT3; Stattic

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STATTIC; SULFOXIDE; VASCULOTROPIN A;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BAGG ALBINO MOUSE; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG EFFECTS; ESOPHAGEAL NEOPLASMS; HUMAN; MALE; METABOLISM; MOUSE; NUDE MOUSE; RADIATION DOSE; RADIATION RESPONSE; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC S-OXIDES; DNA BREAKS, DOUBLE-STRANDED; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; RADIATION TOLERANCE; STAT3 TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84930893037     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2823-y     Document Type: Article

References (24)

1. Pennathur A, Gibson MK, Jobe BA, Luketich JD. Oesophageal carcinoma. Lancet. 2013;381(9864):400–12.
2. Karar J, Maity A. Modulating the tumor microenvironment to increase radiation responsiveness. Cancer Biol Ther. 2009;8(21):1994–2001.
3. Cummins EP, Taylor CT. Hypoxia-responsive transcription factors. Pflugers Arch. 2005;450(6):363–71.
4. Jung JE, Lee HG, Cho IH, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J. 2005;19(10):1296–8.
5. Xu Q, Briggs J, Park S, et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene. 2005;24(36):5552–60.
6. Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 2011;12:9–22.
7. Huang CY, Lin CS, Tai WT, et al. Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3. Int J Radiat Oncol Biol Phys. 2013;86(3):456–62.
8. Bu X, Zhao C, Wang W, et al. GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation. Gene. 2013;512(2):198–205.
9. Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13(11):1235–42.
10. Leong PL, Andrews GA, Johnson DE, et al. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A. 2003;100(7):4138–43.
11. Zhong Z, Wen Z. Darnell JE Jr Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264:95–8.
12. Deng J, Liang H, Zhang R, Sun D, Pan Y, Liu Y, et al. STAT3 is associated with lymph node metastasis in gastric cancer. Tumour Biol. 2013;34:2791–800.
13. Wang T, Niu G, Kortylewski M, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nature Med. 2004;10:48–54.
14. Huang LE, Bindra RS, Glazer PM, Harris AL. Hypoxia-induced genetic instability: a calculated mechanism underlying tumor progression. J Mol Med (Berl). 2007;85:139–48.
15. Sohda M, Ishikawa H, Masuda N, Kato H, Miyazaki T, Nakajima M, et al. Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer. Int J Cancer. 2004;110:838–84.
16. Moon SY, Chang HW, Roh JL, Kim GC, Choi SH, Lee SW, et al. Using YC-1 to overcome the radioresistance of hypoxic cancer cells. Oral Oncol. 2009;45:915–9.
17. Staab A, Fleischer M, Loeffler J, Said HM, Katzer A, Plathow C, et al. Small interfering RNA targeting HIF-1alpha reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlenther Onkol. 2011;187:252–9.
18. Gray MJ, Zhang J, Ellis LM, et al. HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005;24:3110–20.
19. Han Z, Feng J, et al. Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells. Biochem Biophys Res Commun. 2013;435(2):188–94.
20. Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13:1235–42.
21. Pan Y, Zhou F, Zhang R, Claret FX. Stat3 inhibitor stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PLoS ONE. 2013;8(1):e54565.
22. Adachi M, Cui C, Dodge CT, Bhayani MK, Lai SY. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma. Oral Oncol. 2012;48:1220–6.
23. Bonner JA, Trummell HQ, Willey CD, Plants BA, Raisch KP. Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma. Radiother Oncol. 2009;92(3):339–44.
24. Yang X, Yang B, Cai J. Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo. Cancer Biol Ther. 2013;14:1068–73.