메뉴 건너뛰기




Volumn 435, Issue 2, 2013, Pages 188-194

Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells

Author keywords

Chemoresistance; Ovarian cancer; Signaling pathway; STAT3

Indexed keywords

CISPLATIN; CYTOCHROME C; INTERLEUKIN 6; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SMALL INTERFERING RNA; STAT3 PROTEIN;

EID: 84878432699     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.087     Document Type: Article
Times cited : (73)

References (33)
  • 1
    • 84857432805 scopus 로고    scopus 로고
    • Molecular approaches to personalizing management of ovarian cancer
    • Bast R.C. Molecular approaches to personalizing management of ovarian cancer. Ann. Oncol. 2011, 22(Suppl. 8):85-815.
    • (2011) Ann. Oncol. , vol.22 , Issue.SUPPL. 8 , pp. 85-815
    • Bast, R.C.1
  • 2
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer: new molecular targets come of age
    • Yu H., Jove R. The STATs of cancer: new molecular targets come of age. Nat. Rev. Cancer 2004, 4:97-105.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 3
    • 13944279557 scopus 로고    scopus 로고
    • Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential
    • Meinhold-Heerlein I., Bauerschlag D., Hilpert F., et al. Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential. Oncogene 2005, 24:1053-1065.
    • (2005) Oncogene , vol.24 , pp. 1053-1065
    • Meinhold-Heerlein, I.1    Bauerschlag, D.2    Hilpert, F.3
  • 4
    • 33748992592 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 pathway activation in drugresistant ovarian cancer
    • Duan Z., Foster R., Bell D.A., et al. Signal transducers and activators of transcription 3 pathway activation in drugresistant ovarian cancer. Clin. Cancer Res. 2006, 12:5055-5063.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5055-5063
    • Duan, Z.1    Foster, R.2    Bell, D.A.3
  • 5
    • 33751575658 scopus 로고    scopus 로고
    • The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis
    • Rosen D.G., Mercado-Uribe I., Yang G., et al. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer 2006, 107:2730-2740.
    • (2006) Cancer , vol.107 , pp. 2730-2740
    • Rosen, D.G.1    Mercado-Uribe, I.2    Yang, G.3
  • 6
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo Y., Xu F., Lu T., et al. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat. Rev. 2012, 38:904-910.
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 904-910
    • Guo, Y.1    Xu, F.2    Lu, T.3
  • 7
    • 28544449918 scopus 로고    scopus 로고
    • SRC tyrosine kinase and multidrug resistance protein-1inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells
    • George J.A., Chen T., Taylor C.C. SRC tyrosine kinase and multidrug resistance protein-1inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells. Cancer Res. 2005, 65:10381-10388.
    • (2005) Cancer Res. , vol.65 , pp. 10381-10388
    • George, J.A.1    Chen, T.2    Taylor, C.C.3
  • 8
    • 15544369937 scopus 로고    scopus 로고
    • Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
    • Lee S., Choi E.J., Jin C., et al. Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol. Oncol. 2005, 97:26-34.
    • (2005) Gynecol. Oncol. , vol.97 , pp. 26-34
    • Lee, S.1    Choi, E.J.2    Jin, C.3
  • 9
    • 33845865865 scopus 로고    scopus 로고
    • The STAT3 oncogene as a predictive marker of drug resistance
    • Barré B., Vigneron A., Perkins N., et al. The STAT3 oncogene as a predictive marker of drug resistance. Trends Mol. Med. 2007, 13:4-11.
    • (2007) Trends Mol. Med. , vol.13 , pp. 4-11
    • Barré, B.1    Vigneron, A.2    Perkins, N.3
  • 10
    • 73949086090 scopus 로고    scopus 로고
    • A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity
    • Han Z., Hong Z., Chen C., et al. A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity. Carcinogenesis 2009, 30:2014-2022.
    • (2009) Carcinogenesis , vol.30 , pp. 2014-2022
    • Han, Z.1    Hong, Z.2    Chen, C.3
  • 11
    • 33745885674 scopus 로고    scopus 로고
    • STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
    • Zhou W., Grandis J.R., Wells A. STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br. J. Cancer 2006, 95:164-171.
    • (2006) Br. J. Cancer , vol.95 , pp. 164-171
    • Zhou, W.1    Grandis, J.R.2    Wells, A.3
  • 13
    • 33745987641 scopus 로고    scopus 로고
    • Overexpression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner
    • Yan X., Fraser M., Qiu Q., et al. Overexpression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. Gynecol. Oncol. 2006, 102:348-355.
    • (2006) Gynecol. Oncol. , vol.102 , pp. 348-355
    • Yan, X.1    Fraser, M.2    Qiu, Q.3
  • 14
    • 80053138926 scopus 로고    scopus 로고
    • Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation
    • Hong Z., Xiao M., Yang Y., et al. Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation. Carcinogenesis 2011, 32:1550-1558.
    • (2011) Carcinogenesis , vol.32 , pp. 1550-1558
    • Hong, Z.1    Xiao, M.2    Yang, Y.3
  • 15
    • 32944465385 scopus 로고    scopus 로고
    • The anti-human leukocyte antigen-DR monoclonal antibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice
    • Carlo-Stella C., Di Nicola M., Turco M.C., et al. The anti-human leukocyte antigen-DR monoclonal antibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice. Cancer Res. 2006, 66:1799-1808.
    • (2006) Cancer Res. , vol.66 , pp. 1799-1808
    • Carlo-Stella, C.1    Di Nicola, M.2    Turco, M.C.3
  • 16
    • 79960038600 scopus 로고    scopus 로고
    • Labeling mitochondria with TMRM or TMRE
    • Chazotte B. Labeling mitochondria with TMRM or TMRE. Cold Spring Harb. Protoc. 2011, 2011:895-897.
    • (2011) Cold Spring Harb. Protoc. , vol.2011 , pp. 895-897
    • Chazotte, B.1
  • 17
    • 67649969188 scopus 로고    scopus 로고
    • Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    • Guo J.P., Shu S.K., He L., et al. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am. J. Pathol. 2009, 175:324-333.
    • (2009) Am. J. Pathol. , vol.175 , pp. 324-333
    • Guo, J.P.1    Shu, S.K.2    He, L.3
  • 18
    • 84878470747 scopus 로고    scopus 로고
    • Development of porous cellulose-hydrogel system for enhanced transdermal delivery of quercetin and rutin
    • Lee M.H., Kim S.J., Park S.N. Development of porous cellulose-hydrogel system for enhanced transdermal delivery of quercetin and rutin. Korea Polym. J. 2013, 37(3):347-355.
    • (2013) Korea Polym. J. , vol.37 , Issue.3 , pp. 347-355
    • Lee, M.H.1    Kim, S.J.2    Park, S.N.3
  • 19
    • 57649097161 scopus 로고    scopus 로고
    • A serum based analysis of ovarian epithelial tumorigenesis
    • Nolen B., Marrangoni A., Velikokhatnaya L., et al. A serum based analysis of ovarian epithelial tumorigenesis. Gynecol. Oncol. 2009, 112:47-54.
    • (2009) Gynecol. Oncol. , vol.112 , pp. 47-54
    • Nolen, B.1    Marrangoni, A.2    Velikokhatnaya, L.3
  • 20
    • 0027369308 scopus 로고
    • Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelia cancer
    • Moradi M.M., Carson L.F., Weinberg B., et al. Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelia cancer. Cancer 1993, 72:2433-2440.
    • (1993) Cancer , vol.72 , pp. 2433-2440
    • Moradi, M.M.1    Carson, L.F.2    Weinberg, B.3
  • 21
    • 6744262234 scopus 로고    scopus 로고
    • Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel
    • Penson R.T., Kronish K., Duan Z., et al. Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Int. J. Gynecol. Cancer 2000, 10:33-41.
    • (2000) Int. J. Gynecol. Cancer , vol.10 , pp. 33-41
    • Penson, R.T.1    Kronish, K.2    Duan, Z.3
  • 22
    • 84863124281 scopus 로고    scopus 로고
    • Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling
    • Li S., Wang N., Brodt P. Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling. Cancer Res. 2012, 72:865-875.
    • (2012) Cancer Res. , vol.72 , pp. 865-875
    • Li, S.1    Wang, N.2    Brodt, P.3
  • 23
    • 80053487181 scopus 로고    scopus 로고
    • Bioenergetics pathways and therapeutic resistance in gliomas: emerging role of mitochondria
    • Griguer C.E., Oliv C.R. Bioenergetics pathways and therapeutic resistance in gliomas: emerging role of mitochondria. Curr. Pharm. Des. 2011, 17:2421-2427.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 2421-2427
    • Griguer, C.E.1    Oliv, C.R.2
  • 24
    • 79960805560 scopus 로고    scopus 로고
    • Metabolic approaches to overcoming chemoresistance in ovarian cancer
    • Suh D.H., Kim M.K., No J.H., et al. Metabolic approaches to overcoming chemoresistance in ovarian cancer. Ann. N. Y. Acad. Sci. 2011, 1229:53-60.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1229 , pp. 53-60
    • Suh, D.H.1    Kim, M.K.2    No, J.H.3
  • 25
    • 77955525117 scopus 로고    scopus 로고
    • RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells
    • Arora S., Bisanz K.M., Peralta L.A., et al. RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells. Gynecol. Oncol. 2010, 118:220-227.
    • (2010) Gynecol. Oncol. , vol.118 , pp. 220-227
    • Arora, S.1    Bisanz, K.M.2    Peralta, L.A.3
  • 26
    • 84862188915 scopus 로고    scopus 로고
    • A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy
    • Kang J., D'Andrea A.D., Kozono D. A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J. Natl. Cancer Inst. 2012, 104:670-681.
    • (2012) J. Natl. Cancer Inst. , vol.104 , pp. 670-681
    • Kang, J.1    D'Andrea, A.D.2    Kozono, D.3
  • 27
    • 78751549236 scopus 로고    scopus 로고
    • Malignant ascites in ovarian cancer IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
    • Lo C.W., Chen M.W., Hsiao M., et al. Malignant ascites in ovarian cancer IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011, 71:424-434.
    • (2011) Cancer Res. , vol.71 , pp. 424-434
    • Lo, C.W.1    Chen, M.W.2    Hsiao, M.3
  • 28
    • 78650356983 scopus 로고    scopus 로고
    • Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer
    • Guo Y., Nemeth J., O'Brien C., et al. Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer. Clin. Cancer Res. 2010, 16:5759-5769.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5759-5769
    • Guo, Y.1    Nemeth, J.2    O'Brien, C.3
  • 29
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S., Karin E., Terzic J., et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009, 15:103-113.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3
  • 30
    • 0033044188 scopus 로고    scopus 로고
    • Regulation of spontaneous and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines
    • Asschert J.G., Vellenga E., Ruiters M.H., et al. Regulation of spontaneous and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines. Int. J. Cancer 1999, 82:244-249.
    • (1999) Int. J. Cancer , vol.82 , pp. 244-249
    • Asschert, J.G.1    Vellenga, E.2    Ruiters, M.H.3
  • 31
    • 79551627286 scopus 로고    scopus 로고
    • "Metabolic reprogramming" in ovarian cancer cells resistant to cisplatin
    • Montopoli M., Bellanda M., Lonardoni F., et al. "Metabolic reprogramming" in ovarian cancer cells resistant to cisplatin. Curr. Cancer Drug Targets 2011, 11:226-235.
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 226-235
    • Montopoli, M.1    Bellanda, M.2    Lonardoni, F.3
  • 32
    • 80052571587 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251
    • Liu J., Xu X., Feng X., et al. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. J. Exp. Clin. Cancer Res. 2011, 30:80.
    • (2011) J. Exp. Clin. Cancer Res. , vol.30 , pp. 80
    • Liu, J.1    Xu, X.2    Feng, X.3
  • 33
    • 59849101586 scopus 로고    scopus 로고
    • Function of mitochondrial Stat3 in cellular respiration
    • Wegrzyn J., Potla R., Chwae Y.J., et al. Function of mitochondrial Stat3 in cellular respiration. Science 2009, 323:793-797.
    • (2009) Science , vol.323 , pp. 793-797
    • Wegrzyn, J.1    Potla, R.2    Chwae, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.