The GPVI - Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Ungerer, Martin ^a   Li, Zhongmin ^a   Baumgartner, Christine ^a,c   Goebel, Silvia ^a   Vogelmann, Jasmin ^a   Holthoff, Hans Peter ^a   Gawaz, Meinrad ^b   Münch, Götz ^a  

^a ADVANCECOR GMBH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; ANTICOAGULANT AGENT; CLOPIDOGREL; DIPYRIDAMOLE; GLYCOPROTEIN VI; HEPARIN; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; REVACEPT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AREA UNDER THE CURVE; ARTERIAL WALL THICKENING; ARTICLE; BLEEDING TIME; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; ENDOTHELIAL DYSFUNCTION; HISTOPATHOLOGY; LOADING DRUG DOSE; LYMPHOCYTE MIGRATION; MACROPHAGE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RECOMMENDED DRUG DOSE; REPEATED DRUG DOSE; T LYMPHOCYTE; THROMBOCYTE ACTIVATION; THROMBUS; TREATMENT DURATION; VASCULAR DISEASE;

ACETYLCHOLINE; ANIMALS; ATHEROSCLEROSIS; BLEEDING TIME; BODY WEIGHT; CHOLESTEROL; ENDOTHELIUM, VASCULAR; GLYCOPROTEINS; IMMUNOGLOBULIN FC FRAGMENTS; LYMPHOCYTES; MACROPHAGES; MALE; MICE; PLAQUE, ATHEROSCLEROTIC; RABBITS; THROMBOSIS;

EID: 84881540134     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071193     Document Type: Article

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