Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood

Journal of Biological Chemistry

Volumn 287, Issue 35, 2012, Pages 30000-30013

  Jung, Stephanie M ^a   Moroi, Masaaki ^a   Soejima, Kenji ^b   Nakagaki, Tomohiro ^b   Miura, Yoshiki ^c   Berndt, Michael C ^d   Gardiner, Elizabeth E ^e   Howes, Joanna Marie ^a   Pugh, Nicholas ^a   Bihan, Dominique ^a   Watson, Steve P ^f   Farndale, Richard W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Chemo Sero Therapeutic Research Institute   (Japan)

^c KURUME UNIVERSITY   (Japan)

^d DUBLIN CITY UNIVERSITY   (Ireland)

^e MONASH UNIVERSITY   (Australia)

^f UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL ACTIVATION; COLLAGEN; DISSOCIATION; ENZYMES; GLYCOPROTEINS; MONOMERS; PEPTIDES; PLATELETS;

COLLAGEN BINDING; COLLAGEN RECEPTORS; COLLAGENOUS SUBSTRATES; DISSOCIATION CONSTANT; FEEDBACK MECHANISMS; PLATELET ACTIVATION; PLATELET ADHESION; THROMBUS FORMATION;

DIMERS;

COLLAGEN; DIMER; GLYCOPROTEIN VI; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOMER; RECOMBINANT PROTEIN; THROMBIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD FLOW; CONTROLLED STUDY; DIMERIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION;

EID: 84865457895     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.359125     Document Type: Article

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