Antidiabetic mechanism of Coptis chinensis polysaccharide through its antioxidant property involving the JNK pathway

Pharmaceutical Biology

Volumn 53, Issue 7, 2015, Pages 1022-1029

  Jiang, Shuang ^a,b   Wang, Yahong ^c   Ren, Dayong ^d   Li, Jianrui ^a   Yuan, Guangxin ^e   An, Liping ^e   Du, Peige ^e   Ma, Jie ^b  

^a CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

^b JILIN UNIVERSITY   (China)

^c Department of Ophthalmology   (China)

^d JILIN AGRICULTURAL UNIVERSITY   (China)

^e BEIHUA UNIVERSITY   (China)

Author keywords

Hyperglycemic; Hypolipidemic; Oxidative stress; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; ANTIOXIDANT; CATALASE; CCPW; CHOLESTEROL; GLUCOSE; GLUCOSE TRANSPORTER 4; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INSULIN RECEPTOR SUBSTRATE 1; MALONALDEHYDE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYSACCHARIDE; PROTEIN P85; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; COPTIS CHINENSIS; DRUG EFFECT; ENZYME REGULATION; FATTY ACID ANALYSIS; GLUCOSE BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; WEIGHT GAIN; ANIMAL; COPTIS; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; WISTAR RAT;

COPTIS CHINENSIS; RANUNCULACEAE; RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANTIOXIDANTS; COPTIS; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; MALE; MAP KINASE SIGNALING SYSTEM; PLANT EXTRACTS; POLYSACCHARIDES; RATS; RATS, WISTAR;

EID: 84930807469     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2014.952838     Document Type: Article

References (37)

1. Aguirre V, Uchida T, Yenush L. (2000). The c-jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J Biol Chem 275: 9047-54.
2. Aguirre V, Werner ED, Giraud J. (2002). Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277:1531-7.
3. Arumugam S, Hanumantha RBR, Periasamy S. (2008). Antiperoxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats. Food Chem Toxicol 46:3262-7.
4. Bandeira SM, Guedes GS, Fonseca LJ. (2012). Characterization of blood oxidative stress in type 2 diabetes mellitus patients: Increase in lipid peroxidation and SOD activity. Oxid Med Cell Longev 10:81-93.
5. Benny K, Huat T, Chee HT. (2005). Antidiabetic activity of the semi-purified fractions of Averrhoa bilimbi in high fat diet fedstreptozotocin-induced diabetic rats. Life Sci 76:2827-39.
6. Berlett BS, Stadtman ER. (1997). Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272:20313-16.
7. Chen H, Qi X. (2013). Study on the effect of polysaccharides from Solanum nigrum Linne on cellular immune function in tumourbearing mice. Afr J Tradit Complement Altern Med 10:41-6.
8. Chen H, Zhang M, Qu Z. (2008). Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia sinensis). Food Chem 10:559-63.
9. Chi AP, Chen JP, Wang ZZ. (2008). Morphological and structural characterization of a polysaccharide from Gynostemma pentaphyllum Makino and its anti-exercise fatigue activity. Carbohydr Polym 74: 868-74.
10. Dokken BB, Saengsirisuwan V, Kim JS. (2008). Oxidative stress-induced insulin resistance in rat skeletal muscle: Role of glycogen synthase kinase-3. Am J Physiol Endocrinol Metab 294:615-21.
11. Draznin B. (2006). Molecular mechanisms of insulin resistance: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85a: The two sides of a coin. Diabetes 55:2392-7.
12. Finkel T, Holbrook NJ. (2000). Oxidants, oxidative stress and the biology of ageing. Nature 408:239-47.
13. Folli F, Corradi D, Fanti P. (2011). The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: Avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 7:313-24.
14. Gardner CD, Eguchi S, Reynolds CM. (2003). Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells. Exp Biol Med 228:836-42.
15. Hirosumi J, Tuncman G, Chang L. (2002). A central role for JNK in obesity and insulin resistance. Nature 420:333-6.
16. Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature 444:860-7.
17. Jiang S, Du P, An L. (2013). Antidiabetic effect of Coptis chinensis polysaccharide in high-fat diet with STZ-induced diabetic mice. Int J Biol Macromol 55:118-12.
18. Jiang YH, Jiang XL, Wang P. (2008). The antitumor and antioxidative activities of polysaccharides isolated from Isaria farinosa B05.Microbiol Res 16:424-30.
19. Jurczuk M, Brzóska MM. (2004). Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem Toxicol 42:429-38.
20. Kahn SE. (2003). The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19.
21. Kaneto H, Matsuoka TA, Katakami N. (2007). Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes. Curr Mol Med 7:674-86.
22. Kaneto H, Matsuoka TA, Nakatani Y. (2005). Oxidative stress and the JNK pathway in diabetes. Curr Diabetes Rev 1:65-72.
23. Lee TH, Kim SU, Yu SL. (2003). Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood 101:5033-8.
24. Lucchesi AN, Freitas NT. (2013). Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats: A mechanism for diabetic chronic liver disease. Acta Cir Bras 28:502-8.
25. Maechler P, Jornot L, Wollheim CB. (1999). Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 274:27905-13.
26. Moon EY, Han YH, Lee DS. (2004). Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur J Immunol 34:2119-28.
27. Peter G. (2000). Obesity as a medical problem. Nature 404:635-43.
28. Prieto JM, Recio MC, Giner RM. (2003). Influence of traditional Chinese antiinflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol 55:1257-82.
29. Savu O, Ionescu-Tirgoviste C, Atanasiu V. (2012). Increase in total antioxidant capacity of plasma despite high levels of oxidative stress in uncomplicated type 2 diabetes mellitus. J Int Med Res 40:709-16.
30. Srinivasan K, Viswanad B, Ramarao P. (2005). Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:313-20.
31. Susztak K, Raff AC, Schiffer M. (2006). Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55:225-33.
32. Taniguchi CM, Emanuelli B, Kahn CR. (2006). Critical nodes in signaling pathways: Insights into insulin action. Nat Rev Mol Cell Biol 7:85-96.
33. Venkatasamy VV, Pericherla S, Manthuruthil S. (2013). Effect of physical activity on insulin resistance, inflammation and oxidative stress in diabetes mellitus. J Clin Diagn Res 7:1764-6.
34. Wang H, Zhang F, Ye F. (2011). The effect of Coptis chinensis on the signaling network in the squamous carcinoma cells. Front Biosci 1: 326-40.
35. Yuan JF, Zhang ZQ, Fan ZC. (2008). Antioxidant effects and cytotoxicity of three purified polysaccharides from Ligusticum chuanxiong Hort. Carbohydr Polym 74:822-7.
36. Yuan LJ, Tu DW, Ye XL. (2006). Hypoglycemic and hypocholesterolemic effects of Coptis chinensis franch inflorescence. Plant Foods Hum Nutr 61:139-44.
37. Zimmet P, Alberti K, Shaw GJ. (2001). Global and societal implications of the diabetes epidemic. Nature 414:782-7.