Dietary fat intake modifies the effect of a common variant in the LIPC gene on changes in serum lipid concentrations during a long-term weight-loss intervention trial

Journal of Nutrition

Volumn 145, Issue 6, 2015, Pages 1289-1294

  Xu, Min ^a,b   Ng, San San ^d   Bray, George A ^e   Ryan, Donna H ^e   Sacks, Frank M ^a   Ning, Guang ^b,c   Qi, Lu ^a,f,g  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Shanghai Institute of Endocrine and Metabolic Diseases   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^d Department of Molecular Genetics GenoVive ^*  (United States)

^e PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Gene diet interaction; Hepatic lipase; High fat diet; LIPC; Weight loss intervention

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER TRIACYLGLYCEROL LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; FAT INTAKE; LIPH PROTEIN, HUMAN; TRIACYLGLYCEROL LIPASE;

ADOLESCENT; AGED; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FAT INTAKE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; INTERVENTION STUDY; LIPC GENE; LIPID BLOOD LEVEL; LIPID DIET; LOW FAT DIET; MAJOR CLINICAL STUDY; MALE; OBESITY; OUTCOME ASSESSMENT; WEIGHT REDUCTION; ADMINISTRATION AND DOSAGE; ADULT; BLOOD; BODY MASS; DIET THERAPY; GENETICS; LOW CALORY DIET; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

ADULT; AGED; BODY MASS INDEX; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET, HIGH-FAT; DIET, REDUCING; DIETARY FATS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPING TECHNIQUES; HUMANS; LINEAR MODELS; LIPASE; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES; WEIGHT LOSS;

EID: 84930790295     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.212514     Document Type: Article

References (26)

1. Santamarina-Fojo S, Haudenschild C, Amar M. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 1998;9:211-9.
2. Peters BJ, Pett H, Klungel OH, Stricker BH, Psaty BM, Glazer NL, Wiggins KL, Bis JC, de Boer A, Maitland-van der Zee AH. Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI. Atherosclerosis 2011;217:458-64.
3. Zambon A, Deeb SS, Pauletto P, Crepaldi G, Brunzell JD. Hepatic lipase: a marker for cardiovascular disease risk and response to therapy. Curr Opin Lipidol 2003;14:179-89.
4. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010;466:707-13.
5. Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium. Diabetes 2011;60:1329-39.
6. Cohen JC, Wang Z, Grundy SM, Stoesz MR, Guerra R. Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. J Clin Invest 1994;94:2377-84.
7. Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB. Interactions between the 2514C→T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men. Am J Clin Nutr 2005;81:1429-35.
8. Bos G, Dekker JM, Feskens EJ, Ocke MC, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ, Jansen H. Interactions of dietary fat intake and the hepatic lipase -480C→T polymorphism in determining hepatic lipase activity: the Hoorn Study. Am J Clin Nutr 2005;81:911-5.
9. Deeb SS, Zambon A, Carr MC, Ayyobi AF, Brunzell JD. Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res 2003;44:1279-86.
10. Ordovas JM, Corella D, Demissie S, Cupples LA, Couture P, Coltell O, Wilson PW, Schaefer EJ, Tucker KL. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation 2002;106:2315-21.
11. Tai ES, Corella D, Deurenberg-Yap M, Cutter J, Chew SK, Tan CE, Ordovas JM; Singapore National Health Survey. Dietary fat interacts with the -514C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey. J Nutr 2003;133:3399-408.
12. Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009;360:859-73.
13. Qi Q, Bray GA, Smith SR, Hu FB, Sacks FM, Qi L. Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) Trial. Circulation 2011;124:563-71.
14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
15. Xu M, Qi Q, Liang J, Bray GA, Hu FB, Sacks FM, Qi L. Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) Trial. Circulation 2013;127:1283-9.
16. Nettleton JA, Steffen LM, Ballantyne CM, Boerwinkle E, Folsom AR. Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults. Atherosclerosis 2007;194:e131-40.
17. Isaacs A, Sayed-Tabatabaei FA, Njajou OT, Witteman JC, van Duijn CM. The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J Clin Endocrinol Metab 2004;89:3858-63.
18. Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, et al.; Finnish Diabetes Prevention Study. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus:the Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 2004;89:2019-23.
19. Lindi V, Schwab U, Louheranta A, Vessby B, Hermansen K, Tapsell L, Riccardi G, Rivellese AA, Laakso M, Uusitupa MI; KANWU Study Group. The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol:the KANWU Study. Nutr Metab Cardiovasc Dis 2008;18:88-95.
20. Brunzell JD, Zambon A, Deeb SS. The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype. Biochim Biophys Acta 2012;1821:365-72.
21. Cahova M, Dankova H, Palenickova E, Papackova Z, Kazdova L. The opposite effects of high-sucrose and high-fat diet on fatty acid oxidation and very low density lipoprotein secretion in rat model of metabolic syndrome. J Nutr Metab 2012;2012:757205.
22. Qi L, Cho YA. Gene-environment interaction and obesity. Nutr Rev 2008;66:684-94.
23. Qi L. Mendelian randomization in nutritional epidemiology. Nutr Rev 2009;67:439-50.
24. Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, et al. Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study. Lancet 2012;380:572-80.
25. Deeb SS, Peng R. The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity. J Lipid Res 2000;41:155-8.
26. Tahvanainen E, Syvanne M, Frick MH, Murtomaki-Repo S, Antikainen M, Kesaniemi YA, Kauma H, Pasternak A, Taskinen MR, Ehnholm C. Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Investigators. J Clin Invest 1998;101:956-60.