-
1
-
-
0014669160
-
Plasma amino acid levels and insulin secretion in obesity
-
Felig P, Marliss E, Cahill GF Jr. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med. 1969;281:811-816.
-
(1969)
N Engl J Med
, vol.281
, pp. 811-816
-
-
Felig, P.1
Marliss, E.2
Cahill Jr., G.F.3
-
2
-
-
69549097700
-
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
-
Huffman KM, Shah SH, Stevens RD, Bain JR, Muehlbauer M, Slentz CA, Tanner CJ, Kuchibhatla M, Houmard JA, Newgard CB, Kraus WE. Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care. 2009;32:1678-1683.
-
(2009)
Diabetes Care
, vol.32
, pp. 1678-1683
-
-
Huffman, K.M.1
Shah, S.H.2
Stevens, R.D.3
Bain, J.R.4
Muehlbauer, M.5
Slentz, C.A.6
Tanner, C.J.7
Kuchibhatla, M.8
Houmard, J.A.9
Newgard, C.B.10
Kraus, W.E.11
-
3
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009;9:311-326.
-
(2009)
Cell Metab
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
Muehlbauer, M.J.4
Stevens, R.D.5
Lien, L.F.6
Haqq, A.M.7
Shah, S.H.8
Arlotto, M.9
Slentz, C.A.10
Rochon, J.11
Gallup, D.12
Ilkayeva, O.13
Wenner, B.R.14
Yancy Jr., W.S.15
Eisenson, H.16
Musante, G.17
Surwit, R.S.18
Millington, D.S.19
Butler, M.D.20
Svetkey, L.P.21
more..
-
4
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17:448-453.
-
(2011)
Nat Med
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
Larson, M.G.2
Vasan, R.S.3
Cheng, S.4
Rhee, E.P.5
McCabe, E.6
Lewis, G.D.7
Fox, C.S.8
Jacques, P.F.9
Fernandez, C.10
O'Donnell, C.J.11
Carr, S.A.12
Mootha, V.K.13
Florez, J.C.14
Souza, A.15
Melander, O.16
Clish, C.B.17
Gerszten, R.E.18
-
5
-
-
60849104425
-
Changes of the plasma metabolome during an oral glucose tolerance test: Is there more than glucose to look at?
-
Zhao X, Peter A, Fritsche J, Elcnerova M, Fritsche A, Häring HU, Schleicher ED, Xu G, Lehmann R. Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab. 2009;296:E384-E393.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Zhao, X.1
Peter, A.2
Fritsche, J.3
Elcnerova, M.4
Fritsche, A.5
Häring, H.U.6
Schleicher, E.D.7
Xu, G.8
Lehmann, R.9
-
6
-
-
49449083937
-
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
-
Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol. 2008;4:214.
-
(2008)
Mol Syst Biol
, vol.4
, pp. 214
-
-
Shaham, O.1
Wei, R.2
Wang, T.J.3
Ricciardi, C.4
Lewis, G.D.5
Vasan, R.S.6
Carr, S.A.7
Thadhani, R.8
Gerszten, R.E.9
Mootha, V.K.10
-
7
-
-
77949267650
-
Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men
-
Tai ES, Tan ML, Stevens RD, Low YL, Muehlbauer MJ, Goh DL, Ilkayeva OR, Wenner BR, Bain JR, Lee JJ, Lim SC, Khoo CM, Shah SH, Newgard CB. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia. 2010;53:757-767.
-
(2010)
Diabetologia
, vol.53
, pp. 757-767
-
-
Tai, E.S.1
Tan, M.L.2
Stevens, R.D.3
Low, Y.L.4
Muehlbauer, M.J.5
Goh, D.L.6
Ilkayeva, O.R.7
Wenner, B.R.8
Bain, J.R.9
Lee, J.J.10
Lim, S.C.11
Khoo, C.M.12
Shah, S.H.13
Newgard, C.B.14
-
8
-
-
79955387227
-
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss
-
Laferrère B, Reilly D, Arias S, Swerdlow N, Gorroochurn P, Bawa B, Bose M, Teixeira J, Stevens RD, Wenner BR, Bain JR, Muehlbauer MJ, Haqq A, Lien L, Shah SH, Svetkey LP, Newgard CB. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med. 2011;3:80re2.
-
(2011)
Sci Transl Med
, vol.3
-
-
Laferrère, B.1
Reilly, D.2
Arias, S.3
Swerdlow, N.4
Gorroochurn, P.5
Bawa, B.6
Bose, M.7
Teixeira, J.8
Stevens, R.D.9
Wenner, B.R.10
Bain, J.R.11
Muehlbauer, M.J.12
Haqq, A.13
Lien, L.14
Shah, S.H.15
Svetkey, L.P.16
Newgard, C.B.17
-
9
-
-
79955412480
-
Two roads diverge: Weight loss interventions and circulating amino acids
-
Robert E, Gerszten TJW. Two roads diverge: weight loss interventions and circulating amino acids. Sci Transl Med. 2011; 3:80ps15.
-
(2011)
Sci Transl Med
, vol.3
-
-
Robert, E.1
Tjw, G.2
-
10
-
-
40749141596
-
Comparison of strategies for sustaining weight loss: The weight loss maintenance randomized controlled trial
-
Weight Loss Maintenance Collaborative Research Group.
-
Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Gullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Jerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J, Champagne CM, Bauck A, Ard JD, Aicher K; Weight Loss Maintenance Collaborative Research Group. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA. 2008;299:1139-1148.
-
(2008)
JAMA
, vol.299
, pp. 1139-1148
-
-
Svetkey, L.P.1
Stevens, V.J.2
Brantley, P.J.3
Appel, L.J.4
Hollis, J.F.5
Loria, C.M.6
Vollmer, W.M.7
Gullion, C.M.8
Funk, K.9
Smith, P.10
Samuel-Hodge, C.11
Myers, V.12
Lien, L.F.13
Laferriere, D.14
Kennedy, B.15
Jerome, G.J.16
Heinith, F.17
Harsha, D.W.18
Evans, P.19
Erlinger, T.P.20
Dalcin, A.T.21
Coughlin, J.22
Charleston, J.23
Champagne, C.M.24
Bauck, A.25
Ard, J.D.26
Aicher, K.27
more..
-
11
-
-
84856728068
-
Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss
-
Shah SH, Crosslin DR, Haynes CS, Nelson S, Turer CB, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Laferrère B, Gorroochurn P, Teixeira J, Brantley PJ, Stevens VJ, Hollis JF, Appel LJ, Lien LF, Batch B, Newgard CB, Svetkey LP. Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. Diabetologia. 2012;55:321-330.
-
(2012)
Diabetologia
, vol.55
, pp. 321-330
-
-
Shah, S.H.1
Crosslin, D.R.2
Haynes, C.S.3
Nelson, S.4
Turer, C.B.5
Stevens, R.D.6
Muehlbauer, M.J.7
Wenner, B.R.8
Bain, J.R.9
Laferrère, B.10
Gorroochurn, P.11
Teixeira, J.12
Brantley, P.J.13
Stevens, V.J.14
Hollis, J.F.15
Appel, L.J.16
Lien, L.F.17
Batch, B.18
Newgard, C.B.19
Svetkey, L.P.20
more..
-
12
-
-
84857648463
-
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
-
Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikäinen LP, Kangas AJ, Soininen P, Würtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kähönen M, Lehtimäki T, Pietiläinen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Järvelin MR, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A, Ripatti S. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet. 2012;44:269-276.
-
(2012)
Nat Genet
, vol.44
, pp. 269-276
-
-
Kettunen, J.1
Tukiainen, T.2
Sarin, A.P.3
Ortega-Alonso, A.4
Tikkanen, E.5
Lyytikäinen, L.P.6
Kangas, A.J.7
Soininen, P.8
Würtz, P.9
Silander, K.10
Dick, D.M.11
Rose, R.J.12
Savolainen, M.J.13
Viikari, J.14
Kähönen, M.15
Lehtimäki, T.16
Pietiläinen, K.H.17
Inouye, M.18
McCarthy, M.I.19
Jula, A.20
Eriksson, J.21
Raitakari, O.T.22
Salomaa, V.23
Kaprio, J.24
Järvelin, M.R.25
Peltonen, L.26
Perola, M.27
Freimer, N.B.28
Ala-Korpela, M.29
Palotie, A.30
Ripatti, S.31
more..
-
13
-
-
0017149168
-
Insulin, glucagon, aminoacid imbalance, and hepatic encephalopathy
-
Soeters PB, Fischer JE. Insulin, glucagon, aminoacid imbalance, and hepatic encephalopathy. Lancet. 1976;2:880-882.
-
(1976)
Lancet
, vol.2
, pp. 880-882
-
-
Soeters, P.B.1
Fischer, J.E.2
-
14
-
-
84863516095
-
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets
-
Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, Ahlqvist E, Jonsson A, Lyssenko V, Vikman P, Hansson O, Parikh H, Korsgren O, Soni A, Krus U, Zhang E, Jing XJ, Esguerra JL, Wollheim CB, Salehi A, Rosengren A, Renström E, Groop L. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab. 2012;16:122-134.
-
(2012)
Cell Metab
, vol.16
, pp. 122-134
-
-
Taneera, J.1
Lang, S.2
Sharma, A.3
Fadista, J.4
Zhou, Y.5
Ahlqvist, E.6
Jonsson, A.7
Lyssenko, V.8
Vikman, P.9
Hansson, O.10
Parikh, H.11
Korsgren, O.12
Soni, A.13
Krus, U.14
Zhang, E.15
Jing, X.J.16
Esguerra, J.L.17
Wollheim, C.B.18
Salehi, A.19
Rosengren, A.20
Renström, E.21
Groop, L.22
more..
-
15
-
-
84864845456
-
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
-
Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, Li M, Thorleifsson G, Newton-Cheh C, Musunuru K, Pirruccello JP, Saleheen D, Chen L, Stewart A, Schillert A, Thorsteinsdottir U, Thorgeirsson G, Anand S, Engert JC, Morgan T, Spertus J, Stoll M, Berger K, Martinelli N, Girelli D, McKeown PP, Patterson CC, Epstein SE, Devaney J, Burnett MS, Mooser V, Ripatti S, Surakka I, Nieminen MS, Sinisalo J, Lokki ML, Perola M, Havulinna A, de Faire U, Gigante B, Ingelsson E, Zeller T, Wild P, de Bakker PI, Klungel OH, Maitland-van der Zee AH, Peters BJ, de Boer A, Grobbee DE, Kamphuisen PW, Deneer VH, Elbers CC, Onland- Moret NC, Hofker MH, Wijmenga C, Verschuren WM, Boer JM, van der Schouw YT, Rasheed A, Frossard P, Demissie S, Willer C, Do R, Ordovas JM, Abecasis GR, Boehnke M, Mohlke KL, Daly MJ, Guiducci C, Burtt NP, Surti A, Gonzalez E, Purcell S, Gabriel S, Marrugat J, Peden J, Erdmann J, Diemert P, Willenborg C, König IR, Fischer M, Hengstenberg C, Ziegler A, Buysschaert I, Lambrechts D, Van de Werf F, Fox KA, El Mokhtari NE, Rubin D, Schrezenmeir J, Schreiber S, Schäfer A, Danesh J, Blankenberg S, Roberts R, McPherson R, Watkins H, Hall AS, Overvad K, Rimm E, Boerwinkle E, Tybjaerg-Hansen A, Cupples LA, Reilly MP, Melander O, Mannucci PM, Ardissino D, Siscovick D, Elosua R, Stefansson K, O'Donnell CJ, Salomaa V, Rader DJ, Peltonen L, Schwartz SM, Altshuler D, Kathiresan S. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380:572-580.
-
(2012)
Lancet
, vol.380
, pp. 572-580
-
-
Voight, B.F.1
Peloso, G.M.2
Orho-Melander, M.3
Frikke-Schmidt, R.4
Barbalic, M.5
Jensen, M.K.6
Hindy, G.7
Hólm, H.8
Ding, E.L.9
Johnson, T.10
Schunkert, H.11
Samani, N.J.12
Clarke, R.13
Hopewell, J.C.14
Thompson, J.F.15
Li, M.16
Thorleifsson, G.17
Newton-Cheh, C.18
Musunuru, K.19
Pirruccello, J.P.20
Saleheen, D.21
Chen, L.22
Stewart, A.23
Schillert, A.24
Thorsteinsdottir, U.25
Thorgeirsson, G.26
Anand, S.27
Engert, J.C.28
Morgan, T.29
Spertus, J.30
Stoll, M.31
Berger, K.32
Martinelli, N.33
Girelli, D.34
McKeown, P.P.35
Patterson, C.C.36
Epstein, S.E.37
Devaney, J.38
Burnett, M.S.39
Mooser, V.40
Ripatti, S.41
Surakka, I.42
Nieminen, M.S.43
Sinisalo, J.44
Lokki, M.L.45
Perola, M.46
Havulinna, A.47
De Faire, U.48
Gigante, B.49
Ingelsson, E.50
Zeller, T.51
Wild, P.52
De Bakker, P.I.53
Klungel, O.H.54
Maitland-Van Der Zee, A.H.55
Peters, B.J.56
De Boer, A.57
Grobbee, D.E.58
Kamphuisen, P.W.59
Deneer, V.H.60
Elbers, C.C.61
Onland- Moret, N.C.62
Hofker, M.H.63
Wijmenga, C.64
Verschuren, W.M.65
Boer, J.M.66
Van Der Schouw, Y.T.67
Rasheed, A.68
Frossard, P.69
Demissie, S.70
Willer, C.71
Do, R.72
Ordovas, J.M.73
Abecasis, G.R.74
Boehnke, M.75
Mohlke, K.L.76
Daly, M.J.77
Guiducci, C.78
Burtt, N.P.79
Surti, A.80
Gonzalez, E.81
Purcell, S.82
Gabriel, S.83
Marrugat, J.84
Peden, J.85
Erdmann, J.86
Diemert, P.87
Willenborg, C.88
König, I.R.89
Fischer, M.90
Hengstenberg, C.91
Ziegler, A.92
Buysschaert, I.93
Lambrechts, D.94
Van De Werf, F.95
Fox, K.A.96
El Mokhtari, N.E.97
Rubin, D.98
Schrezenmeir, J.99
more..
-
16
-
-
84859215358
-
The interleukin-6 receptor as a target for prevention of coronary heart disease: A mendelian randomisation analysis
-
Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium
-
Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium; Hingorani A, Casas JP. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet. 2012;379:1214-1224.
-
(2012)
Lancet
, vol.379
, pp. 1214-1224
-
-
Hingorani, A.1
Casas, J.P.2
-
17
-
-
77956018249
-
Mendelian randomization in nutritional epidemiology
-
Qi L. Mendelian randomization in nutritional epidemiology. Nutr Rev. 2009;67:439-450.
-
(2009)
Nutr Rev
, vol.67
, pp. 439-450
-
-
Qi, L.1
-
18
-
-
61449183682
-
Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
-
Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, Leboff MS, Rood JC, de Jonge L, Greenway FL, Loria CM, Obarzanek E, Williamson DA. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009;360:859-873.
-
(2009)
N Engl J Med
, vol.360
, pp. 859-873
-
-
Sacks, F.M.1
Bray, G.A.2
Carey, V.J.3
Smith, S.R.4
Ryan, D.H.5
Anton, S.D.6
McManus, K.7
Champagne, C.M.8
Bishop, L.M.9
Laranjo, N.10
Leboff, M.S.11
Rood, J.C.12
De Jonge, L.13
Greenway, F.L.14
Loria, C.M.15
Obarzanek, E.16
Williamson, D.A.17
-
19
-
-
80051548943
-
Insulin receptor substrate 1 gene variation modifies insulin resistance response to weightloss diets in a 2-year randomized trial: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial
-
Qi Q, Bray GA, Smith SR, Hu FB, Sacks FM, Qi L. Insulin receptor substrate 1 gene variation modifies insulin resistance response to weightloss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. Circulation. 2011;124:563-571.
-
(2011)
Circulation
, vol.124
, pp. 563-571
-
-
Qi, Q.1
Bray, G.A.2
Smith, S.R.3
Hu, F.B.4
Sacks, F.M.5
Qi, L.6
-
20
-
-
84856401524
-
Weight-loss diets modify glucose- dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: The Preventing Overweight Using Novel Dietary Strategies trial
-
Qi Q, Bray GA, Hu FB, Sacks FM, Qi L. Weight-loss diets modify glucose- dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial. Am J Clin Nutr. 2012;95:506-513.
-
(2012)
Am J Clin Nutr
, vol.95
, pp. 506-513
-
-
Qi, Q.1
Bray, G.A.2
Hu, F.B.3
Sacks, F.M.4
Qi, L.5
-
21
-
-
84860439210
-
Interplay between lipids and branched-chain amino acids in development of insulin resistance
-
Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012;15:606-614.
-
(2012)
Cell Metab
, vol.15
, pp. 606-614
-
-
Newgard, C.B.1
-
22
-
-
84863386821
-
Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase
-
Wynn RM, Li J, Brautigam CA, Chuang JL, Chuang DT. Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase. J Biol Chem. 2012;287:9178-9192.
-
(2012)
J Biol Chem
, vol.287
, pp. 9178-9192
-
-
Wynn, R.M.1
Li, J.2
Brautigam, C.A.3
Chuang, J.L.4
Chuang, D.T.5
-
23
-
-
0029113443
-
Exploration of simple insulin sensitivity measures derived from frequently sampled intravenous glucose tolerance (FSIGT) tests: The Insulin Resistance Atherosclerosis Study
-
Anderson RL, Hamman RF, Savage PJ, Saad MF, Laws A, Kades WW, Sands RE, Cefalu W. Exploration of simple insulin sensitivity measures derived from frequently sampled intravenous glucose tolerance (FSIGT) tests: the Insulin Resistance Atherosclerosis Study. Am J Epidemiol. 1995;142:724-732.
-
(1995)
Am J Epidemiol
, vol.142
, pp. 724-732
-
-
Anderson, R.L.1
Hamman, R.F.2
Savage, P.J.3
Saad, M.F.4
Laws, A.5
Kades, W.W.6
Sands, R.E.7
Cefalu, W.8
-
24
-
-
0032896330
-
Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas
-
Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, Shoji T, Okuno Y, Morii H. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care. 1999;22:818-822.
-
(1999)
Diabetes Care
, vol.22
, pp. 818-822
-
-
Emoto, M.1
Nishizawa, Y.2
Maekawa, K.3
Hiura, Y.4
Kanda, H.5
Kawagishi, T.6
Shoji, T.7
Okuno, Y.8
Morii, H.9
|