The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 18, Issue 2, 2008, Pages 88-95

  Lindi, Virpi ^a   Schwab, Ursula ^a,b   Louheranta, Anne ^a,b   Vessby, Bengt ^c   Hermansen, Kjeld ^d   Tapsell, Linda ^e   Riccardi, Gabriele ^f   Rivellese, Angela A ^f   Laakso, Markku ^a   Uusitupa, Matti I J ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UPPSALA UNIVERSITY   (Sweden)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e UNIVERSITY OF WOLLONGONG   (Australia)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Diet; Fat; Fish oil; Hepatic lipase; Lipoproteins; Polymorphism

Indexed keywords

FATTY ACID; FISH OIL; HEPATIC LIPASE, HUMAN; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOUNSATURATED FATTY ACID; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUSTRALIA; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENZYMOLOGY; EUROPE; FAT INTAKE; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN RESISTANCE; LIVER; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PHENOTYPE; POSTPRANDIAL STATE; PROMOTER REGION; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; TIME;

ADULT; AUSTRALIA; BLOOD GLUCOSE; CHOLESTEROL, LDL; DIETARY FATS; EUROPE; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FEMALE; FISH OILS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERCHOLESTEROLEMIA; INSULIN; INSULIN RESISTANCE; LIPASE; LIVER; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPRANDIAL PERIOD; PROMOTER REGIONS (GENETICS); TIME FACTORS;

EID: 39549104680     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2006.09.008     Document Type: Article

References (32)

1. Deeb S.S., Zambon A., Carr M.C., Ayyobi A.F., and Brunzell J.D. Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res 44 (2003) 1279-1286
2. Zambon A., Bertocco S., Vitturi N., Polentarutti V., Vianello D., and Crepaldi G. Relevance of hepatic lipase to the metabolism of triacylglycerol-rich lipoproteins. Biochem Soc Trans 31 (2003) 1070-1074
3. Guerra R., Wang J., Grundy S.M., and Cohen J.C. A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 94 (1997) 4532-4537
4. 2 cholesterol. Arterioscler Thromb Vasc Biol 18 (1998) 1723-1729
5. Carr M.C., Hokanson J.E., Deeb S.S., Purnell J.Q., Mitchell E.S., and Brunzell J.D. A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. Arterioscler Thromb Vasc Biol 19 (1999) 2701-2707
6. Bos G., Dekker J.M., Feskens E.J., Ocke M.C., Nijpels G., Stehouwer C.D., et al. Interactions of dietary fat intake and the hepatic lipase -480C → T polymorphism in determining hepatic lipase activity: the Hoorn Study. Am J Clin Nutr 81 (2005) 911-915
7. Tahvanainen E., Syvänne M., Frick M.H., Murtomäki-Repo S., Antikainen M., Kesäniemi Y.A., et al. Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Investigators. J Clin Invest 101 (1998) 956-960
8. Pihlajamäki J., Karjalainen L., Karhapää P., Vauhkonen I., Taskinen M.R., Deeb S.S., et al. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 20 (2000) 1789-1795
9. Stefan N., Schäfer S., Machicao F., Machann J., Schick F., Claussen C.D., et al. Liver fat and insulin resistance are independently associated with the -514C > T polymorphism of the hepatic lipase gene. J Clin Endocrinol Metab 90 (2005) 4238-4243
10. Jansen H., Waterworth D.M., Nicaud V., Ehnholm C., and Talmud P.J. Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). Ann Hum Genet 65 (2001) 237-243
11. Zacharova J., Todorova B.R., Chiasson J.L., and Laakso M. The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. J Intern Med 257 (2005) 185-193
12. Todorova B., Kubaszek A., Pihlajamäki J., Lindström J., Eriksson J., Valle T.T., et al. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 89 (2004) 2019-2023
13. Ordovas J.M., Corella D., Demissie S., Cupples L.A., Couture P., Coltell O., et al. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation 106 (2002) 2315-2321
14. Tai E.S., Corella D., Deurenberg-Yap M., Cutter J., Chew S.K., Tan C.E., et al. Dietary fat interacts with the -514C > T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey. J Nutr 133 (2003) 3399-3408
15. Gomez P., Perez-Jimenez F., Marin C., Moreno J.A., Gomez M.J., Bellido C., et al. The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population. J Mol Endocrinol 34 (2005) 331-338
16. Vessby B., Uusitupa M., Hermansen K., Riccardi G., Rivellese A.A., Tapsell L.C., et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 44 (2001) 312-319
17. WHO. World Health Organization Expert Committee on Diabetes mellitus. Technical report series no 742. Geneva; 1985.
18. Rivellese A.A., Maffettone A., Vessby B., Uusitupa M., Hermansen K., Berglund L., et al. Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects. Atherosclerosis 167 (2003) 149-158 10.1016/S0021-9150(02)00424-0
19. Seigler L., and Wu W.T. Separation of serum high-density lipoprotein for cholesterol determination: ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride. Clin Chem 27 (1981) 838-841
20. Penttilä I.M., Voutilainen E., Laitinen P., and Juutilainen P. Comparison of different analytical and precipitation methods for direct estimation of serum high-density lipoprotein cholesterol. Scand J Clin Lab Invest 41 (1981) 353-360
21. Nilsson-Ehle P., and Ekman R. Rapid, simple and specific assays for lipoprotein lipase and hepatic lipase. Artery 3 (1977) 194-209
22. Steil G.M., Volund A., Kahn S.E., and Bergman R.N. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies. Diabetes 42 (1993) 250-256
23. Pacini G., and Bergman R.N. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 23 (1986) 113-122 10.1016/0169-2607(86)90106-9
24. Andersen L., Dinesen B., Jorgensen P.N., Poulsen F., and Roder M.E. Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 39 (1993) 578-582
25. Banauch D., Brummer W., Ebeling W., Metz H., Rindfrey H., Lang H., et al. A glucose dehydrogenase for the determination of glucose concentrations in body fluids (article in German). Z Klin Chem Klin Biochem 13 (1975) 101-107
26. Karvonen M.K., Pesonen U., Koulu M., Niskanen L., Laakso M., Rissanen A., et al. Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat Med 4 (1998) 1434-1437
27. Tsukamoto K., Watanabe T., Matsushima T., Kinoshita M., Kato H., Hashimoto Y., et al. Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med 121 (1993) 598-602
28. Reaven G., and Miller R. Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes 17 (1968) 560-569
29. Dietschy J.M. Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations. J Nutr 128 (1998) 444S-448S
30. Zambon A., Deeb S.S., Bensadoun A., Foster K.E., and Brunzell J.D. In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity. J Lipid Res 41 (2000) 2094-2099
31. Jansen H., Verhoeven A.J., Weeks L., Kastelein J.J., Halley D.J., van den Ouweland A., et al. Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. Arterioscler Thromb Vasc Biol 17 (1997) 2837-2842
32. 3 in African American men: CARDIA study. J Lipid Res 42 (2001) 258-264