The acute and sub-chronic effects of cocoa flavanols on mood, cognitive and cardiovascular health in young healthy adults: A randomized, controlled trial

Frontiers in Pharmacology

Volumn 6, Issue MAY, 2015, Pages

  Massee, Laura A ^a   Ried, Karin ^b   Pase, Matthew ^a,c   Travica, Nikolaj ^b   Yoganathan, Jaesshanth ^a   Scholey, Andrew ^a   Macpherson, Helen ^a   Kennedy, Greg ^a   Sali, Avni ^b   Pipingas, Andrew ^a  

^a SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

^b National Institute of Integrative Medicine   (Australia)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular; Chocolate; Cocoa; Cognition; Flavanols; Mental fatigue; Mood

Indexed keywords

FLAVANOL DERIVATIVE; PLACEBO;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRAIN BLOOD FLOW; CACAO; CARDIOVASCULAR FUNCTION; COGNITION; COGNITIVE DEMAND BATTERY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DYSTHYMIA; FEMALE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; MALE; MOOD; NORMAL HUMAN; PSYCHOLOGIC ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RAPID VISUAL INFORMATION PROCESSING; SELF REPORT; SUPPLEMENTATION; SWINBURNE UNIVERSITY COMPUTERIZED COGNITIVE ASSESSMENT BATTERY; TASK PERFORMANCE; YOUNG ADULT;

EID: 84930653189     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00093     Document Type: Article

References (45)

1. Abd El Mohsen, M. M., Kuhnle, G., Rechner, A. R., Schroeter, H., Rose, S., Jenner, P., et al. (2002). Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radic. Biol. Med. 33, 1693-1702. doi: 10.1016/S0891-5849(02)01137-1.
2. Bravo, L. (1998). Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev. 56, 317-333. doi: 10.1111/j.1753-4887.1998.tb01670.x.
3. Brickman, A. M., Khan, U. A., Provenzano, F. A., Yeung, L. K., Suzuki, W., Schroeter, H., et al. (2014). Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat. Neurosci. 17, 1798-1803. doi: 10.1038/nn.3850.
4. Butlin, M., Qasem, A., and Avolio, A. P. (2012). Estimation of central aortic pressure waveform features derived from the brachial cuff volume displacement waveform. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 2591-2594. doi: 10.1109/EMBC.2012.6346494.
5. Cooper, K. A., Donovan, J. L., Waterhouse, A. I., and Williamson, G. (2008). Cocoa and health: a decade of research. Br. J. Nutr. 99, 1-11. doi: 10.1017/S0007114507795296.
6. Corti, R., Flammer, A. J., Hollenberg, N. K., and Luscher, T. F. (2009). Cocoa and cardiovascular health. Circulation 119, 1433-1441. doi: 10.1161/CIRCULATIONAHA.108.827022.
7. Crews, W. D. Jr., Harrison, D. W., and Wright, J. W. (2008). A double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adults. Am. J. Clin. Nutr. 87, 872-880.
8. Desideri, G., Kwik-Uribe, C., Grassi, D., Necozione, S., Ghiadoni, L., Mastroiacovo, D., et al. (2012). Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the cocoa, cognition, and aging (CoCoA) study. Hypertension 60, 794-801. doi: 10.1161/HYPERTENSIONAHA.112.193060.
9. Dinges, D. F. (2006). Cocoa flavanols, cerebral blood flow, cognition, and health: going forward. J. Cardiovasc. Pharmacol. 47, S221-S223. doi: 10.1097/00005344-200606001-00019.
10. Faridi, Z., Njike, V. Y., Dutta, S., Ali, A., and Katz, D. L. (2008). Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am. J. Clin. Nutr. 88, 58-63.
11. Field, D. T., Williams, C. M., and Butler, L. T. (2011). Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol. Behav. 103, 255-260. doi: 10.1016/j.physbeh.2011.02.013.
12. Fisher, N. D. L., Sorond, F. A., and Hollenberg, N. K. (2006). Cocoa flavanols and brain perfusion. J. Cardiovasc. Pharmacol. 47, S210-S214. doi: 10.1097/00005344-200606001-00017.
13. Fraga, C. G., Litterio, M. C., Prince, P. D., Calabro, V., Piotrkowski, B., and Galleano, M. (2011). Cocoa flavanols: effects on vascular nitric oxide and blood pressure. J. Clin. Biochem. Nutr. 48, 63-67. doi: 10.3164/jcbn.11-010FR.
14. Francis, S. T., Head, K., Morris, P. G., and Macdonald, I. A. (2006). The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J. Cardiovasc. Pharmacol. 47, S215-S220. doi: 10.1097/00005344-200606001-00018.
15. Galleano, M., Oteiza, P. I., and Fraga, C. G. (2009). Cocoa, chocolate, and cardiovascular disease. J. Cardiovasc. Pharmacol. 54, 483-494. doi: 10.1097/FJC.0b013e3181b76787.
16. Grassi, D., Desideri, G., Necozione, S., Lippi, C., Casale, R., Properzi, G., et al. (2008). Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J. Nutr. 138, 1671-1676.
17. Gu, L., Kelm, M. A., Hammerstone, J. F., Beecher, G., Holden, J., Haytowitz, D., et al. (2004). Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J. Nutr. 134, 613-617.
18. Hollenberg, N. K., Fisher, N. D. L., and McCullough, M. L. (2009). Flavanols, the Kuna, cocoa consumption, and nitric oxide. J. Am. Soc. Hypertens. 3, 105-112. doi: 10.1016/j.jash.2008.11.001.
19. Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., et al. (2008). Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 88, 38-50.
20. Joseph, J. A., Shukitt-Hale, B., and Lau, F. C. (2007). Fruit polyphenols and their effects on neuronal signalling and behavior in senescence. Annu. N.Y. Acad. Sci. 1100, 470-485. doi: 10.1196/annals.1395.052.
21. Katz, D. L., Doughty, K., and Ali, A. (2011). Cocoa and chocolate in human health and disease. Antioxid. Redox Signal. 15, 2779-2811. doi: 10.1089/ars.2010.3697.
22. Kennedy, D. O., and Scholey, A. B. (2004). A glucose-caffeine 'energy drink' ameliorates subjective and performance deficits during prolonged cognitive demand. Appetite 42, 331-333. doi: 10.1016/j.appet.2004.03.001.
23. Latif, R. (2013). Chocolate/cocoa and human health: a review. Neth. J. Med. 71, 63-68.
24. Letenneur, L., Proust-Lima, C., Le Gouge, A., Dartigues, J. F., and Barberger-Gateau, P. (2007). Flavonoid intake and cognitive decline over a 10-year period. Am. J. Epidemiol. 16, 1364-1371. doi: 10.1093/aje/kwm036.
25. Lippi, D. (2009). Chocolate and medicine: dangerous liasions? Nutrition 25, 1100-1113. doi: 10.1016/j.nut.2009.08.002.
26. Lippi, D. (2013). Chocolate in history: food, medicine, medi-food. Nutrients 5, 1573-1584. doi: 10.3390/nu5051573.
27. Macready, A. L., Kennedy, O. B., Ellis, J. A., Williams, C. M., Spencer, J. P., and Butler, L. T. (2009). Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies. Genes Nutr. 4, 227-242. doi: 10.1007/s12263-009-0135-4.
28. Monahan, K. D., Feehan, R. P., Kunselman, A. R., Preston, A. G., Miller, D. L., and Lott, M. E. (2011). Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults. J. Appl. Physiol. 111, 1568-1574. doi: 10.1152/japplphysiol.00865.2011.
29. Nehlig, A. (2013). The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br. J. Clin. Pharmacol. 75, 716-727. doi: 10.1111/j.1365-2125.2012.04378.x.
30. Njike, V. Y., Faridi, Z., Shuval, K., Dutta, S., Kay, C. D., West, S. G., et al. (2011). Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults. Int. J. Cardiol. 149, 83-88. doi: 10.1016/j.ijcard.2009.12.010.
31. Nurk, E., Refsum, H., Drevon, C. A., Tell, G. S., Nygaard, H. A., Engedal, K., et al. (2009). Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J. Nutr. 139, 120-127. doi: 10.3945/jn.108.095182.
32. Pase, M. P., Scholey, A. B., Pipingas, A., Kras, M., Noldin, K., Gibbs, A., et al. (2013). Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial. J. Psychopharmacol. 27, 451-458. doi: 10.1177/0269881112473791.
33. Pipingas, A., Harris, E., Tournier, E., King, R., Kras, M., and Stough, C. K. (2010). Assessing the efficacy of nutraceutical interventions on cognitive functioning in the elderly. Curr. Top. Nutraceutical Res. 8, 79-88.
34. Pucciarelli, D. L. (2013). Cocoa and heart health: a historical review of the science. Nutrients 5, 3854-3870. doi: 10.3390/nu5103854.
35. Ried, K., Sullivan, T., Fakler, P., Frank, O. R., and Stocks, N. P. (2010). Does chocolate reduce blood pressure? A meta-analysis. BMC Med. 8:39. doi: 10.1186/1741-7015-8-39.
36. Ried, K., Sullivan, T. R., Fakler, P., Frank, O. R., and Stocks, N. P. (2012). Effect of cocoa on blood pressure. Cochrane Database Syst. Rev. 8:CD008893. doi: 10.1002/14651858.CD008893.pub2.
37. Scholey, A. B., French, S. J., Morris, P. J., Kennedy, D. O., Milne, A. L., and Haskell, C. F. (2010). Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J. Psychopharmacol. 24, 1505-1514. doi: 10.1177/0269881109106923.
38. Shukitt-Hale, B., Carey, A., Simon, L., Mark, D. A., and Joseph, J. A. (2006). Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition 22, 295-302. doi: 10.1016/j.nut.2005.07.016.
39. Shukitt-Hale, B., Lau, F. C., and Joseph, J. A. (2008). Berry fruit supple-mentation and the aging brain. J. Agric. Food Chem. 56, 636-641. doi: 10.1021/jf072505f.
40. Sorond, F. A., Lipsitz, L. A., Hollenberg, N. K., and Fisher, N. D. L. (2008). Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr. Dis. Treat. 4, 433-440.
41. Spencer, J. P. E. (2007). The interactions of flavonoids within neuronal signalling pathways. Genes Nutr. 2, 257-273. doi: 10.1007/s12263-007-0056-z.
42. Spencer, J. P. E. (2009). Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr. 4, 243-250. doi: 10.1007/s12263-009-0136-3.
43. Steinberg, F. M., Bearden, M. M., and Keen, C. L. (2003). Cocoa and chocolate flavonoids: implications for cardiovascular health. J. Am. Diet. Assoc. 103, 215-223. doi: 10.1053/jada.2003.50028.
44. Taubert, D., Roesen, R., Lehmann, C., Jung, N., and Schomig, E. (2007). Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. J. Am. Med. Assoc. 298, 49-60. doi: 10.1001/jama.298.1.49.
45. Williams, R. J., and Spencer, J. P. E. (2012). Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic. Biol. Med. 52, 35-45. doi: 10.1016/j.freeradbiomed.2011.09.010.