Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells

Cell Death and Disease

Volumn 6, Issue , 2015, Pages

  Guadagno, J ^a   Swan, P ^a   Shaikh, R ^a   Cregan, S P ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LIPOPOLYSACCHARIDE; PROTEIN BAX; PROTEIN NOXA; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; RECOMBINANT INTERLEUKIN 1BETA; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; IL1B PROTEIN, HUMAN; INTERLEUKIN 1BETA; ONCOPROTEIN; PMAIP1 PROTEIN, HUMAN; PROTEIN BCL 2; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; MICROGLIA; MITOCHONDRION; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL PRECURSOR CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STEM CELL; UPREGULATION; ANIMAL; CELL CULTURE; CELL CYCLE CHECKPOINT; CYTOLOGY; ENZYME ACTIVATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; NERVE REGENERATION; NEURAL STEM CELL; PHYSIOLOGY;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME ACTIVATION; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MICROGLIA; MITOCHONDRIA; NERVE REGENERATION; NEURAL STEM CELLS; NEUROGENESIS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84930642170     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.151     Document Type: Article

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