Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart

Cardiovascular Drugs and Therapy

Volumn 23, Issue 6, 2009, Pages 459-469

  Kasumov, Takhar ^a,b   Sharma, Naveen ^a   Huang, Hazel ^a   Kombu, Rajan S ^a   Cendrowski, Andrea ^a   Stanley, William C ^a,c   Brunengraber, Henri ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Anaplerosis; Citric acid cycle; Heart; Ischemia; Propionate; Reperfusion

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; CITRIC ACID; CYSTEINE; DIPROPIONYLCYSTEINE ETHYL ESTER; FATTY ACID; FUMARIC ACID; GLUCOSE; LACTIC ACID; MALIC ACID; PROPIONIC ACID; SUCCINIC ACID; UNCLASSIFIED DRUG; ANTIOXIDANT; DRUG DERIVATIVE; N,S DIPROPIONYLCYSTEINE ETHYL ESTER; N,S-DIPROPIONYLCYSTEINE ETHYL ESTER; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CITRIC ACID CYCLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG DOSE ESCALATION; DRUG STRUCTURE; DRUG SYNTHESIS; HEART FUNCTION; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART RATE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; OXYGEN SATURATION; PRIORITY JOURNAL; REPERFUSION INJURY; SWINE; ANIMAL; DOSE RESPONSE; DRUG EFFECT; MASS FRAGMENTOGRAPHY;

ANIMALS; ANTIOXIDANTS; CITRIC ACID CYCLE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; PROPIONATES; SWINE;

EID: 77649198926     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-009-6208-1     Document Type: Article

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