Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods

Journal of Medicinal Chemistry

Volumn 58, Issue 10, 2015, Pages 4230-4241

  Minegishi, Hidemitsu ^a,b   Futamura, Yushi ^c   Fukashiro, Shinji ^b   Muroi, Makoto ^c   Kawatani, Makoto ^c   Osada, Hiroyuki ^c   Nakamura, Hiroyuki ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b GAKUSHUIN UNIVERSITY   (Japan)

^c RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ISOBUTOXY 3 ISOTHIOCYANATOBENZENE; 2 [(6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 YL)AMINO]PHENOL; 3 (PHENYLAMINO) 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 6 OL; 3 [(6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 YL)AMINO]BENZOIC ACID; 3 [(6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 YL)AMINO]PHENOL; 6 ETHOXY N PHENYL 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; 6 METHOXY N (2 METHOXYPHENYL) 1,4 DIHYDROINDENO[1,2 C] PYRAZOL 3 AMINE; 6 METHOXY N (3 METHOXYPHENYL) 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; 6 METHOXY N (4 METHOXYPHENYL) 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; 6 [(TERT BUTYLDIMETHYLSILYL)OXY]N PHENYL 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE; METHYL 3 ISOTHIOCYANATOBENZOATE; METHYL 3 [(6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 YL)AMINO]BENZOATE; N (3 ISOBUTOXYPHENYL) 6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; N (3,4 DIMETHOXYPHENYL) 6 METHOXY 1,4 DIHYDROINDENO [1,2 C]PYRAZOL 3 AMINE; N (3,5 DIMETHOXYPHENYL) 6 METHOXY 1,4 DIHYDROINDENO [1,2 C]PYRAZOL 3 AMINE; N [2 [(TERT BUTYLDIMETHYLSILYL)OXY]PHENYL] 6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; N [3 [(TERT BUTYLDIMETHYLSILYL)OXY]PHENYL] 6 METHOXY 1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 AMINE; PHENYL ISOTHIOCYANATE; TERT BUTYL(2 ISOTHIOCYANATOPHENOXY)DIMETHYLSILANE; TERT BUTYL(3 ISOTHIOCYANATOPHENOXY)DIMETHYLSILANE; UNCLASSIFIED DRUG; 3 AMINOBENZOIC ACID DERIVATIVE; ANTIINFECTIVE AGENT; GN39482; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; TUBULIN MODULATOR;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MTT ASSAY; PLASMODIUM FALCIPARUM 3D7; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; TUBULIN POLYMERIZATION ASSAY; WESTERN BLOTTING; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROTUBULE; PLASMODIUM FALCIPARUM; PROCEDURES; SYNTHESIS;

ANTI-INFECTIVE AGENTS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; META-AMINOBENZOATES; MICROBIAL SENSITIVITY TESTS; MICROTUBULES; PLASMODIUM FALCIPARUM; PROTEIN KINASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 84930630278     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00035     Document Type: Article

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