Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 285-288

  Usui, Taikou ^a   Ban, Hyun Seung ^a   Kawada, Junpei ^a   Hirokawa, Takatsugu ^b   Nakamura, Hiroyuki ^a  

^a GAKUSHUIN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

EGFR; In silico screening; Indenopyrazoles; Tyrosine kinase inhibitor; VEGFR

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INDENOPYRAZOLE DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CELL GROWTH; COMPUTER MODEL; DRUG DESIGN; DRUG RESEARCH; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; NONHUMAN;

BINDING SITES; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PYRAZOLES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 37549048987     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.084     Document Type: Article

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