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Volumn 17, Issue 21, 2007, Pages 5944-5951

Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Author keywords

Antitumor agent; Checkpoint kinase 1; Chk1 inhibitors; Combination therapy; DNA damage; Pyrazole; Structure activity relationship

Indexed keywords

4' (1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 YL)BENZONITRILE DERIVATIVE; 4' (1,4 DIHYDROINDENO[1,2 C]PYRAZOL 3 YL)PYRIDINE 2' CARBONITRILE; 7 HYDROXYSTAUROSPORINE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 1 INHIBITOR; DNA; DOXORUBICIN; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; NITRILE; PROTEIN KINASE;

EID: 34548826539     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.102     Document Type: Article
Times cited : (28)

References (29)
  • 28
    • 34548828970 scopus 로고    scopus 로고
    • note
    • 50 values of the inhibitor alone and the inhibitor with Dox. For more details about the assay, see Ref. 10.
  • 29
    • 34548813497 scopus 로고    scopus 로고
    • note
    • H1299 cells were treated with Chk1 inhibitors in the presence and absence of Dox (500 nM) and their detailed cell cycle kinetics were analyzed by using FACS. For more details about the assay, see Ref. 10.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.