Application of partial least squares and radial basis function neural networks in multivariate imaging analysis-quantitative structure activity relationship: Study of cyclin dependent kinase 4 inhibitors

Journal of Molecular Graphics and Modelling

Volumn 29, Issue 4, 2010, Pages 518-528

  Saghaie, Lotfollah ^a,b   Shahlaei, Mohsen ^a,c   Madadkar Sobhani, Armin ^d   Fassihi, Afshin ^a,b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Isfahan Pharmaceutical Sciences Research Center   (Iran)

^c KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Cyclin dependent kinase 4 inhibitors; Multivariate imaging analysis quantitative structure activity relationship; Partial least squares; Radial basis function neural networks

Indexed keywords

2D IMAGES; CYCLIN-DEPENDENT KINASE; DATA MINING METHODS; DATA SETS; DEPENDENT VARIABLES; DEVELOPED MODEL; IMAGING ANALYSIS; MULTIVARIATE IMAGE ANALYSIS; PARTIAL LEAST SQUARES; PLS MODELS; PRINCIPAL COMPONENTS; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS; RADIAL BASIS FUNCTION NEURAL NETWORKS; STATISTICAL QUALITY; VALIDATION METHODS;

ATTITUDE CONTROL; MULTIVARIANT ANALYSIS; NEURAL NETWORKS; PRINCIPAL COMPONENT ANALYSIS;

RADIAL BASIS FUNCTION NETWORKS;

CYCLIN DEPENDENT KINASE 4 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL NEURAL NETWORK; DRUG ACTIVITY; IC 50; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

CYCLIN-DEPENDENT KINASE 4; IMAGE PROCESSING, COMPUTER-ASSISTED; INHIBITORY CONCENTRATION 50; LEAST-SQUARES ANALYSIS; MODELS, MOLECULAR; MULTIVARIATE ANALYSIS; NEURAL NETWORKS (COMPUTER); PRINCIPAL COMPONENT ANALYSIS; PROTEIN KINASE INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650513678     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2010.10.001     Document Type: Article

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