Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii

Molecular Systems Biology

Volumn 9, Issue , 2013, Pages

  Song, Carl ^a,b   Chiasson, Melissa A ^c   Nursimulu, Nirvana ^a,d   Hung, Stacy S ^a,b   Wasmuth, James ^a,e   Grigg, Michael E ^c   Parkinson, John ^a,b,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

Author keywords

Flux balance analysis; Metabolic reconstruction; Strain differences; Toxoplasma gondii

Indexed keywords

5 CHLORO 8 QUINOLINOL; 5,5' DITHIOBIS(2 NITROBENZOIC ACID); 8 QUINOLINOL; ACYLTRANSFERASE; ALDEHYDE DEHYDROGENASE; ALENDRONIC ACID; ARGININE; ASPARTIC ACID; CARBAMATE KINASE; CLODRONIC ACID; GLUTATHIONE DISULFIDE; GLYCINE; HISTIDINE; LEUCINE; LYSINE; ORNITHINE CARBAMOYLTRANSFERASE; PEPTIDE ALPHA N ACETYLTRANSFERASE; PHENYLALANINE; PYRIDOXAL 5 PHOSPHATE; PYRIMETHAMINE; PYRROLINE 5 CARBOXYLATE DEHYDROGENASE; QUINOLINE DERIVATIVE; SERINE; SULFADIAZINE; THIOREDOXIN REDUCTASE; THREONINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE; ANTIPROTOZOAL AGENT; BISPHOSPHONIC ACID DERIVATIVE;

AMINO ACID SYNTHESIS; ARTICLE; BIOMASS PRODUCTION; CELL GROWTH; COMPUTER MODEL; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; ENERGY YIELD; ENZYME MECHANISM; GLYCOLYSIS; GROWTH RATE; HOST RANGE; INTRACELLULAR TRANSPORT; METABOLIC ENGINEERING; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SIMULATION; STOICHIOMETRY; TOXOPLASMA GONDII; UPREGULATION; BIOLOGICAL MODEL; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HOST PARASITE INTERACTION; HUMAN; METABOLISM; PARASITOLOGY; PATHOGENICITY; SPECIES DIFFERENCE; TOXOPLASMA; VIRULENCE; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIAL VIRULENCE; FUNCTIONAL GENOMICS; HOST PATHOGEN INTERACTION; METABOLIC REGULATION; NONHUMAN; DRUG EFFECT;

TOXOPLASMA GONDII;

ANTIPROTOZOAL AGENTS; DIPHOSPHONATES; DRUG RESISTANCE; FIBROBLASTS; GENE EXPRESSION REGULATION; HOST SPECIFICITY; HOST-PARASITE INTERACTIONS; HUMANS; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; MODELS, GENETIC; QUINOLINES; SPECIES SPECIFICITY; TOXOPLASMA; VIRULENCE;

EID: 84888149629     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2013.62     Document Type: Article

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